Distinct roles of deiodinases on the phenotype of Mct8 defect: A comparison of eight different mouse genotypes

Endocrinology

Volumn 152, Issue 3, 2011, Pages 1180-1191

  Liao, Xiao Hui ^a   Di Cosmo, Caterina ^a   Dumitrescu, Alexandra M ^a   Hernandez, Arturo ^b   Van Sande, Jacqueline ^c   St Germain, Donald L ^b   Weiss, Roy E ^a   Galton, Valerie Anne ^b   Refetoff, Samuel ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IODIDE PEROXIDASE; MONOCARBOXYLATE TRANSPORTER 8; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEIODINATION; GENOTYPE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THYROTOXICOSIS;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; IODIDE PEROXIDASE; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE;

EID: 79951883954     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0900     Document Type: Article

References (38)

1. Kopp P, Solis-Sainz JC 2009 Thyroid hormone synthesis. In: Wondisford FE, Radovick S, eds. Clinical management of thyroid disease. Philadelphia: Saunders/Elsevier; 19-41
2. Jansen J, Friesema EC, Milici C, Visser TJ 2005 Thyroid hormone transporters in health and disease. Thyroid 15:757-768 (Pubitemid 41339256)
3. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC 2008 Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev 29:898-938
4. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89 (Pubitemid 34185306)
5. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128-40135 (Pubitemid 37248580)
6. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168-175 (Pubitemid 38085248)
7. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437 (Pubitemid 39370719)
8. Schwartz CE, Stevenson RE 2007 The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome. Best Pract Res Clin Endocrinol Metab 21:307-321 (Pubitemid 46888197)
9. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S 2006 Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 147:4036-4043 (Pubitemid 44268357)
10. Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H 2007 Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest 117:627-635 (Pubitemid 46348521)
11. Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S 2009 A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology 150:4450-4458
12. Trajkovic-Arsic M, Visser TJ, Darras VM, Friesema EC, Schlott B, Mittag J, Bauer K, Heuer H 2010 Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice. Endocrinology 151:802-809
13. Di Cosmo C, Liao XH, Dumitrescu AM, Philp NJ, Weiss RE, Refetoff S 2010 Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. J Clin Invest 120:3377-3388
14. Trajkovic-Arsic M, Müller J, Darras VM, Groba C, Lee S, Weih D, Bauer K, Visser TJ, Heuer H 2010 Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. Endocrinology 151:5053-5062
15. Galton VA, Schneider MJ, Clark AS, St. Germain DL 2009 Life without thyroxine to 3,5,3′-triiodothyronine conversion: studies in mice devoid of the 5′-deiodinases. Endocrinology 150:2957-2963
16. Pohlenz J, Maqueem A, Cua K, Weiss RE, Van Sande J, Refetoff S 1999 Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid 9:1265-1271 (Pubitemid 30038940)
17. Perret J, Ludgate M, Libert F, Gerard C, Dumont JE, Vassart G, Parmentier M 1990 Stable expression of the human TSH receptor in CHO-K1 cells and characterization of differentially expressing clones. Biochem Biophys Res Commun 171:1044-1050 (Pubitemid 20318055)
18. Moeller LC, Kimura S, Kusakabe T, Liao XH, Van Sande J, Refetoff S 2003 Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid stimulating hormone receptor. Mol Endocrinol 17:2295-2302 (Pubitemid 37352539)
19. Radonić A, Thulke S, Mackay IM, Landt O, Siegert W, Nitsche A 2004 Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun 313:856-862 (Pubitemid 38050071)
20. Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S 2005 Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat Genet 37:1247-1252 (Pubitemid 41568708)
21. Balzano S, Bergmann BM, Gilliland MA, Silva JE, Rechtschaffen A, Refetoff S 1990 Effect of total sleep deprivation on 5′-deiodinase activity of rat brown adipose tissue. Endocrinology 127:882-890 (Pubitemid 20248135)
22. Galton VA, Martinez E, Hernandez A, St Germain EA, Bates JM, St. Germain DL 1999 Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase. J Clin Invest 103:979-987 (Pubitemid 29169605)
23. Morreale de Escobar G, Pastor R, Obregon MJ, Escobar del Rey F 1985 Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 117:1890-1900 (Pubitemid 16200779)
24. Morreale de Escobar G, Calvo R, Escobar del Rey F, Obregón MJ 1994 Thyroid hormones in tissues from fetal and adult rats. Endocrinology 134:2410-2415 (Pubitemid 24170851)
25. Kero J, Ahmed K, Wettschureck N, Tunaru S, Wintermantel T, Greiner E, Schütz G, Offermanns S 2007 Thyrocyte-specific G (q)/G(11) deficiency impairs thyroid function and prevents goiter development. J Clin Invest 117:2399-2407 (Pubitemid 47494342)
26. Alonso M, Goodwin C, Liao X, Page D, Refetoff S, Weiss RE 2007 Effects of maternal levels of thyroid hormone (TH) on the hypothalamus-pituitary-thyroid set point: studies in TH receptor beta knockout mice. Endocrinology 148:5305-5312 (Pubitemid 350012660)
27. Morte B, Ceballos A, Diez D, Grijota-Martínez C, Dumitrescu AM, Di Cosmo C, Galton VA, Refetoff S, Bernal J 2010 Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice. Endocrinology 151:2381-2387
28. Ricquier D 1999 Uncoupling protein-2 (UCP2): molecular and genetic studies. Int J Obes Relat Metab Disord 23(Suppl 6):S38-S42 (Pubitemid 29322608)
29. Fukuda H, Hirakawa T, Iritani N 2007 Nutritional and hormonal regulation of uncoupling protein gene expression in rat adipocytes. J Nutr Sci Vitaminol (Tokyo) 53:426-431 (Pubitemid 350144342)
30. Galton VA, Wood ET, St. Germain EA, Withrow CA, Aldrich G, St. Germain GM, Clark AS, St. Germain DL 2007 Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. Endocrinology 148:3080-3088 (Pubitemid 46997018)
31. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA 2008 A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28:264-278
32. Kwakkel J, Chassande O, van Beeren HC, Fliers E, Wiersinga WM, Boelen A 2010 Thyroid hormone receptor α modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism. Endocrinology 151:1959-1969
33. Schneider MJ, Fiering SN, Thai B, Wu SY, St. Germain E, Parlow AF, St. Germain DL, Galton VA 2006 Targeted disruption of the type 1 selenodeiodinase gene (dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology 147:580-589 (Pubitemid 43008392)
34. Salvatore D, Tu H, Harney JW, Larsen PR 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 98:962-968 (Pubitemid 26293314)
35. Gereben B, Salvatore D, Harney JW, Tu HM, Larsen PR 2001 The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1). Mol Endocrinol 15:112-124 (Pubitemid 32156045)
36. Celi FS, Coppotelli G, Chidakel A, Kelly M, Brillante BA, Shawker T, Cherman N, Feuillan PP, Collins MT 2008 The role of type 1 and type 2 5′-deiodinase in the pathophysiology of the 3,5,3′-triiodothyronine toxicosis of McCune-Albright syndrome. J Clin Endocrinol Metab 93:2383-2389 (Pubitemid 351831562)
37. van Staveren WC, Solís DW, Delys L, Venet D, Cappello M, Andry G, Dumont JE, Libert F, Detours V, Maenhaut C 2006 Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis. Proc Natl Acad Sci USA 103:413-418 (Pubitemid 43122415)
38. Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami M, Murata Y 2007 Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity. J Clin Endocrinol Metab 92:1451-1457 (Pubitemid 46556425)