Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues

Thyroid

Volumn 21, Issue 12, 2011, Pages 1323-1330

  Geers, Caroline ^a   Colin, Ides M ^b   Gérard, Anne Catherine ^b  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA LIKE 4 RECEPTOR; MEMBRANE RECEPTOR; NOTCH1 RECEPTOR; NOTCH4 RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; GRAVES DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID DISEASE; THYROID FOLLICULAR CARCINOMA; THYROID HYPERPLASIA; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; BELGIUM; BLOTTING, WESTERN; GRAVES DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID GLAND; THYROID NEOPLASMS;

EID: 82955186960     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2010.0444     Document Type: Article

References (27)

1. Duda DG, Batchelor TT, Willett CG, Jain RK 2007 VEGFtargeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med 13:223-230. (Pubitemid 46836870)
2. Ferrara N 2005 VEGF as a therapeutic target in cancer. Oncology 69 Suppl 3:11-16. (Pubitemid 41680948)
3. Casanovas O, Hicklin DJ, Bergers G, Hanahan D 2005 Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8:299-309. (Pubitemid 41443415)
4. Dufraine J, Funahashi Y, Kitajewski J 2008 Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene 27:5132-5137.
5. Sainson RC, Harris AL 2007 Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med 13:389-395. (Pubitemid 47385383)
6. Thurston G, Kitajewski J 2008 VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer 99:1204-1209.
7. Rehman AO, Wang CY 2006 Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol 16:293-300. (Pubitemid 43884979)
8. Roy M, Pear WS, Aster JC 2007 The multifaceted role of Notch in cancer. Curr Opin Genet Dev 17:52-59. (Pubitemid 46109291)
9. Kintner C 1992 Molecular bases of early neural development in Xenopus embryos. Annu Rev Neurosci 15:251-284.
10. Hainaud P, Contreres JO, Villemain A, Liu LX, Tobelem G, Dupuy E 2006 The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res 66:8501-8510. (Pubitemid 44449163)
11. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalén M, Gerhardt H, Betsholtz C 2007 Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445:776-780. (Pubitemid 46279716)
12. Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD 2004 Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 101:15949-15954. (Pubitemid 39507907)
13. Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T 2004 Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 18:2469-2473. (Pubitemid 39362888)
14. Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A 2007 The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci USA 104:3225-3230. (Pubitemid 46364141)
15. Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, Plowman G, Yan M 2006 Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444:1083-1087. (Pubitemid 46018529)
16. Scehnet JS, Jiang W, Kumar SR, Krasnoperov V, Trindade A, Benedito R, Djokovic D, Borges C, Ley EJ, Duarte A, Gill PS 2007 Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 109:4753-4760. (Pubitemid 46827768)
17. Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G 2006 Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444:1032-1037. (Pubitemid 46018516)
18. Gerard AC, Xhenseval V, Colin IM, Many MC, Denef JF 2000 Evidence for co-ordinated changes between vascular endothelial growth factor and nitric oxide synthase III immunoreactivity, the functional status of the thyroid follicles, and the microvascular bed during chronic stimulation by low iodine and propylthiouracyl in old mice. Eur J Endocrinol 142:651-660. (Pubitemid 30399498)
19. Gerard AC, Many MC, Daumerie C, Costagliola S, Miot F, DeVijlder JJ, Colin IM, Denef JF 2002 Structural changes in the angiofollicular units between active and hypofunctioning follicles align with differences in the epithelial expression of newly discovered proteins involved in iodine transport and organification. J Clin Endocrinol Metab 87: 1291-1299. (Pubitemid 36121101)
20. Gerard AC, Denef JF, Many MC, Gathy P, de Burbure C, van den Hove MF, Coppée F, Ledent C, Colin IM 2003 Relationships between cell division, expression of growth factors and microcirculation in the thyroids of Tg-A2aR transgenic mice and patients with Graves' disease. J Endocrinol 177:269-277. (Pubitemid 36656400)
21. Gerard AC, Poncin S, Caetano B, Sonveaux P, Audinot JN, Feron O, Colin IM, Soncin F 2008 Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. Am J Pathol 172:748-760. (Pubitemid 351354547)
22. Ferretti E, Tosi E, Po A, Scipioni A, Morisi R, Espinola MS, Russo D, Durante C, Schlumberger M, Screpanti I, Filetti S, Gulino A 2008 Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors. J Clin Endocrinol Metab 93:4080-4087.
23. Artavanis-Tsakonas S, Delidakis C, Fehon R, Hartley D, Herndon V, Johansen K, Markopoulou K, Preiss A, Rebay I, Scottgale N, Xu T 1990 Notch and the molecular genetics of neuroblast segregation in Drosophila. Mol Reprod Dev 27:23-27. (Pubitemid 20328347)
24. Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D 2001 Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69:135-144. (Pubitemid 33755062)
25. Mazella J, Liang S, Tseng L 2008 Expression of Delta-like protein 4 in the human endometrium. Endocrinology 149:15-19.
26. Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL 2005 Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 65:8690-8697. (Pubitemid 41377356)
27. Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li JL, Harris AL 2006 Upregulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 12:4836-4844. (Pubitemid 44338568)