Notch signaling regulates tumor angiogenesis by diverse mechanisms

Oncogene

Volumn 27, Issue 38, 2008, Pages 5132-5137

  Dufraine, J ^a   Funahashi, Y ^b   Kitajewski, J ^a  

^a NewYork Presbyterian Hospital   (United States)

^b EISAI CO LTD   (Japan)

Author keywords

Angiogenesis; Dll4; Jagged1; Notch; Sprout; VEGFR 2

Indexed keywords

ANGIOPOIETIN; DELTA LIKE 4 PROTEIN; FIBROBLAST GROWTH FACTOR; JAGGED1; MEMBRANE PROTEIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTERY; CANCER INHIBITION; CELL BUDDING; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; DEGRADATION; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; TISSUE DIFFERENTIATION; TUMOR ANGIOGENESIS;

ANIMALS; ARTERIES; CALCIUM-BINDING PROTEINS; CELL COMMUNICATION; CELL DIFFERENTIATION; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; NEOPLASM PROTEINS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 50849103301     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.227     Document Type: Review

References (41)

1. Alva JA, Iruela-Arispe ML. (2004). Notch signaling in vascular morphogenesis. Curr Opin Hematol 11: 278-283.
2. Artavanis-Tsakonas S, Rand MD, Lake RJ. (1999). Notch signaling: cell fate control and signal integration in development. Science 284: 770-776.
3. Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ et al. (2005). Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci USA 102: 9884-9889.
4. Claxton S, Fruttiger M. (2004). Periodic Delta-like 4 expression in developing retinal arteries. Gene Expr Patterns 5: 123-127.
5. Funahashi Y, Hernandez SL, Das I, Ahn A, Huang J, Vorontchikhina M et al. (2008). A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res 68: 4727-4735.
6. Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM et al. (2004). Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 101: 15949-15954.
7. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A et al. (2003). VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161: 1163-1177.
8. Greenwald I. (1998). LIN-12/Notch signaling: lessons from worms and flies. Genes Dev 12: 1751-1762.
9. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P et al. (2007). Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445: 776-780.
10. High FA, Epstein JA. (2008). The multifaceted role of Notch in cardiac development and disease. Nat Rev Genet 9: 49-61.
11. High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. (2008). Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci USA 105: 1955-1959.
12. Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M et al. (2006). Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. Biochem Biophys Res Commun 341: 708-714.
13. Jain RK, Duda DG, Clark JW, Loeffler JS. (2006). Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3: 24-40.
14. Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T. (2004). Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 18: 2469-2473.
15. Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP et al. (2000). Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 14: 1343-1352.
16. Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA et al. (2001). Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128: 3675-3683.
17. Lawson ND, Weinstein BM. (2002). Arteries and veins: making a difference with zebrafish. Nat Rev Genet 3: 674-682.
18. Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT, Liao JK. (2005). Essential role of endothelial Notch1 in angiogenesis. Circulation 111: 1826-1832.
19. Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD et al. (2007). Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA 104: 3219-3224.
20. Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D. (2001). Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69: 135-144.
21. Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW et al. (2006). Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444: 1032-1037.
22. Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K et al. (2006). Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 12: 4836-4844.
23. Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. (2005). Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 65: 8690-8697.
24. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V et al. (2004). Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167: 215-221.
25. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR et al. (2005). High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65: 8530-8537.
26. Reedijk M, Pinnaduwage D, Dickson BC, Mulligan AM, Zhang H, Bull SB et al. (2007). JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat; e-pub ahead of print.
27. Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y et al. (2006). Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444: 1083-1087.
28. Scehnet JS, Jiang W, Kumar SR, Krasnoperov V, Trindade A, Benedito R et al. (2007). Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 109: 4753-4760.
29. Shawber CJ, Das I, Francisco E, Kitajewski J. (2003). Notch signaling in primary endothelial cells. Ann NY Acad Sci 995: 162-170.
30. Siekmann AF, Lawson ND. (2007). Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 445: 781-784.
31. Stylianou S, Clarke RB, Brennan K. (2006). Aberrant activation of notch signaling in human breast cancer. Cancer Res 66: 1517-1525.
32. Suchting S, Freitas C, Ie Noble F, Benedito R, Breant C, Duarte A et al. (2007). The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci USA 104: 3225-3230.
33. Takeshita K, Satoh M, Li M, Silver M, Limbourg FP, Mukai Y et al. (2007). Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res 100: 70-78.
34. Thurston G, Noguera-Troise I, Yancopoulos GD. (2007). The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 7: 327-331.
35. Uyttendaele H, Ho J, Rossant J, Kitajewski J. (2001). Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci USA 98: 5643-5648.
36. Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G. (2001). Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev 108: 161-164.
37. Wang HU, Chen ZF, Anderson DJ. (1998). Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93: 741-753.
38. Xue Y, Gao X, Lindsell CE, Norton CR, Chang B, Hicks C et al. (1999). Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet 8: 723-730.
39. Zeng Q, Li S, Chepeha DB, Giordano TJ, Li J, Zhang H et al. (2005). Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8: 13-23.
40. Zhong TP, Childs S, Leu JP, Fishman MC. (2001). Gridlock signalling pathway fashions the first embryonic artery. Nature 414: 216-220.
41. Zhong TP, Rosenberg M, Mohideen MA, Weinstein B, Fishman MC. (2000). gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science 287: 1820-1824.