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Volumn 120, Issue 9, 2010, Pages 3377-3388

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; IODINE 125; LIOTHYRONINE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 8; THYROTROPIN; THYROXINE; TRICHLOROACETIC ACID;

EID: 77956379884     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI42113     Document Type: Article
Times cited : (154)

References (45)
  • 1
    • 0027288003 scopus 로고
    • Iodide transport in the thyroid
    • Carrasco N. Iodide transport in the thyroid. Biochim Biophys Acta. 1993;1154(1):65-82.
    • (1993) Biochim Biophys Acta , vol.1154 , Issue.1 , pp. 65-82
    • Carrasco, N.1
  • 2
    • 16944366606 scopus 로고    scopus 로고
    • Pendred syndrome is caused by mutations in a putative sulphate transport gene (PDS)
    • Everett LA, et al. Pendred syndrome is caused by mutations in a putative sulphate transport gene (PDS). Nature Genet. 1997;17(4):411-422.
    • (1997) Nature Genet , vol.17 , Issue.4 , pp. 411-422
    • Everett, L.A.1
  • 3
    • 0014724834 scopus 로고
    • Thyroid peroxidase and thyroxine biosynthesis
    • Taurog A. Thyroid peroxidase and thyroxine biosynthesis. Recent Prog Horm Res. 1970;26:189-247.
    • (1970) Recent Prog Horm Res , vol.26 , pp. 189-247
    • Taurog, A.1
  • 4
    • 0034725643 scopus 로고    scopus 로고
    • Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family
    • De Deken X, et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem. 2000;275(30):23227-23233.
    • (2000) J Biol Chem , vol.275 , Issue.30 , pp. 23227-23233
    • De Deken, X.1
  • 5
    • 0038481173 scopus 로고    scopus 로고
    • Thyroid functions of mouse cathepsins B, K, and L
    • Friedrichs B, et al. Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003;111(11):1733-1745.
    • (2003) J Clin Invest , vol.111 , Issue.11 , pp. 1733-1745
    • Friedrichs, B.1
  • 6
    • 9444274840 scopus 로고    scopus 로고
    • Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site
    • Gnidehou S, et al. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J. 2004;18(13):1574-1576.
    • (2004) FASEB J , vol.18 , Issue.13 , pp. 1574-1576
    • Gnidehou, S.1
  • 7
    • 0026768659 scopus 로고
    • The free hormone hypothesis and measurement of free hormones
    • Ekins R. The free hormone hypothesis and measurement of free hormones. Clin Chem. 1992;38(7):1289-1293.
    • (1992) Clin Chem , vol.38 , Issue.7 , pp. 1289-1293
    • Ekins, R.1
  • 9
    • 0034892914 scopus 로고    scopus 로고
    • Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability
    • Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev. 2001;22(4):451-476.
    • (2001) Endocr Rev , vol.22 , Issue.4 , pp. 451-476
    • Hennemann, G.1    Docter, R.2    Friesema, E.C.3    De Jong, M.4    Krenning, E.P.5    Visser, T.J.6
  • 11
    • 74749085075 scopus 로고    scopus 로고
    • Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters
    • van der Deure WM, Peeters RP, Visser TJ. Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters. J Mol Endocrinol. 2010;44(1):1-11.
    • (2010) J Mol Endocrinol , vol.44 , Issue.1 , pp. 1-11
    • Van Der Deure, W.M.1    Peeters, R.P.2    Visser, T.J.3
  • 12
    • 0347634343 scopus 로고    scopus 로고
    • A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
    • Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet. 2004;74(1):168-175.
    • (2004) Am J Hum Genet , vol.74 , Issue.1 , pp. 168-175
    • Dumitrescu, A.M.1    Liao, X.H.2    Best, T.B.3    Brockmann, K.4    Refetoff, S.5
  • 13
    • 5644276275 scopus 로고    scopus 로고
    • Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
    • Friesema EC, et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet. 2004;364(9443):1435-1437.
    • (2004) Lancet , vol.364 , Issue.9443 , pp. 1435-1437
    • Friesema, E.C.1
  • 14
    • 33747590148 scopus 로고    scopus 로고
    • Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
    • Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S. Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology. 2006;147(9):4036-4043.
    • (2006) Endocrinology , vol.147 , Issue.9 , pp. 4036-4043
    • Dumitrescu, A.M.1    Liao, X.H.2    Weiss, R.E.3    Millen, K.4    Refetoff, S.5
  • 15
    • 33847400151 scopus 로고    scopus 로고
    • Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
    • Trajkovic M, et al. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest. 2007;117(3):627-635.
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 627-635
    • Trajkovic, M.1
  • 16
    • 15444378008 scopus 로고    scopus 로고
    • The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone sensitive neuron populations
    • Heuer H, et al. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone sensitive neuron populations. Endocrinology. 2005;146(4):1701-1706.
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 1701-1706
    • Heuer, H.1
  • 17
    • 69249115321 scopus 로고    scopus 로고
    • A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport
    • Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S. A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology. 2009;150(9):4450-4458.
    • (2009) Endocrinology , vol.150 , Issue.9 , pp. 4450-4458
    • Di Cosmo, C.1    Liao, X.H.2    Dumitrescu, A.M.3    Weiss, R.E.4    Refetoff, S.5
  • 18
    • 66449128624 scopus 로고    scopus 로고
    • Importance of monocarboxylate transporter 8 (Mct8) for the blood-brain barrier dependent availability of 3,5,3′-triiodo-l-thyronine (T3)
    • Ceballos A, et al. Importance of monocarboxylate transporter 8 (Mct8) for the blood-brain barrier dependent availability of 3,5,3′-triiodo-l- thyronine (T3). Endocrinology. 2009;150(5):2491-2496.
    • (2009) Endocrinology , vol.150 , Issue.5 , pp. 2491-2496
    • Ceballos, A.1
  • 19
    • 33751536051 scopus 로고    scopus 로고
    • Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism
    • Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH. Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol. 2006;20(11):2761-2772.
    • (2006) Mol Endocrinol , vol.20 , Issue.11 , pp. 2761-2772
    • Friesema, E.C.1    Kuiper, G.G.2    Jansen, J.3    Visser, T.J.4    Kester, M.H.5
  • 20
    • 25144492671 scopus 로고    scopus 로고
    • The effects of iodine deficiency on thyroid hormone deiodination
    • Obregon MJ, Escobar del Rey F, Morreale de Escobar G. The effects of iodine deficiency on thyroid hormone deiodination. Thyroid. 2005;15(8):917-929.
    • (2005) Thyroid , vol.15 , Issue.8 , pp. 917-929
    • Obregon, M.J.1    Escobar Del Rey, F.2    Morreale De Escobar, G.3
  • 21
    • 33645891683 scopus 로고    scopus 로고
    • Mechanisms of adaptation to iodine deficiency in rats: Thyroid status is tissue specific. Its relevance for man
    • Pedraza PE, Obregon MJ, Escobar-Morreale HF, del Rey FE, de Escobar GM. Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man. Endocrinology. 2006;147(5):2098-2108.
    • (2006) Endocrinology , vol.147 , Issue.5 , pp. 2098-2108
    • Pedraza, P.E.1    Obregon, M.J.2    Escobar-Morreale, H.F.3    Del Rey, F.E.4    De Escobar, G.M.5
  • 22
    • 33747882489 scopus 로고    scopus 로고
    • Thyroid regulatory factors
    • DeGroot LJ, Jameson JL, eds. Philadephia, Pennsylvania, USA: Elsevier, Mosby, Saunders
    • Dumont JE, Maenhaut C, Christophe D, Vassart G, Roger PP. Thyroid regulatory factors. In: DeGroot LJ, Jameson JL, eds. Endocrinology. Volume 2. Philadephia, Pennsylvania, USA: Elsevier, Mosby, Saunders; 2006:1837-1860.
    • (2006) Endocrinology , vol.2 , pp. 1837-1860
    • Dumont, J.E.1    Maenhaut, C.2    Christophe, D.3    Vassart, G.4    Roger, P.P.5
  • 25
    • 0000194228 scopus 로고
    • Thyroidal iodine heterogeneity: "last come, first served" system of iodine turnover
    • Schneider PB. Thyroidal iodine heterogeneity: "last come, first served" system of iodine turnover. Endocrinology. 1964;74:973-980.
    • (1964) Endocrinology , vol.74 , pp. 973-980
    • Schneider, P.B.1
  • 26
    • 0017168924 scopus 로고
    • Isopycnic centrifugation of thyroid iodoproteins: Selectivity of endocytosis
    • Cortese F, Schneider AB, Salvatore G. Isopycnic centrifugation of thyroid iodoproteins: selectivity of endocytosis. Eur J Biochem. 1976;68(1):121-129.
    • (1976) Eur J Biochem , vol.68 , Issue.1 , pp. 121-129
    • Cortese, F.1    Schneider, A.B.2    Salvatore, G.3
  • 27
    • 0026743033 scopus 로고
    • The thyrotropin receptor and the regulation of thyrocyte function and growth
    • Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992;13(3):596-611.
    • (1992) Endocr Rev , vol.13 , Issue.3 , pp. 596-611
    • Vassart, G.1    Dumont, J.E.2
  • 28
    • 0031010758 scopus 로고    scopus 로고
    • Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells
    • Kogai T, Endo T, Saito T, Miyazaki A, Kaaguchi A, Onaya T. Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells. Endocrinology. 1997;138(6):2227-2232.
    • (1997) Endocrinology , vol.138 , Issue.6 , pp. 2227-2232
    • Kogai, T.1    Endo, T.2    Saito, T.3    Miyazaki, A.4    Kaaguchi, A.5    Onaya, T.6
  • 29
    • 0030978104 scopus 로고    scopus 로고
    • +/I-symporter with an anti-COOH terminus antibody
    • +/I-symporter with an anti-COOH terminus antibody. Proc Natl Acad Sci U S A. 1997;94(11):5568-5573.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.11 , pp. 5568-5573
    • Levy, O.1
  • 30
    • 0024814832 scopus 로고
    • Control of thyroperoxidase and thyroglobulin transcription by cAMP: Evidence for distinct regulatory mechanisms
    • Gerard CM, et al. Control of thyroperoxidase and thyroglobulin transcription by cAMP: evidence for distinct regulatory mechanisms. Mol Endocrinol. 1989;3(12):2110-2118.
    • (1989) Mol Endocrinol , vol.3 , Issue.12 , pp. 2110-2118
    • Gerard, C.M.1
  • 32
    • 0023611379 scopus 로고
    • Thyrotropin stimulation of cultured thyroid cells increases steady state levels of the messenger ribonucleic acid for thyroid peroxidase
    • Chazenbalk G, Magnusson RP, Rapoport B. Thyrotropin stimulation of cultured thyroid cells increases steady state levels of the messenger ribonucleic acid for thyroid peroxidase. Mol Endocrinol. 1987;1(12):913-917.
    • (1987) Mol Endocrinol , vol.1 , Issue.12 , pp. 913-917
    • Chazenbalk, G.1    Magnusson, R.P.2    Rapoport, B.3
  • 33
    • 0028349191 scopus 로고
    • Cytokines modulate type I iodothyronine deiodinase mRNA levels and enzyme activity in FRTL-5 rat thyroid cells
    • Pekary AE, Berg L, Santini F, Chopra I, Hershman JM. Cytokines modulate type I iodothyronine deiodinase mRNA levels and enzyme activity in FRTL-5 rat thyroid cells. Mol Cell Endocrinol. 1994;101(1-2):R31-R35.
    • (1994) Mol Cell Endocrinol , vol.101 , Issue.1-2
    • Pekary, A.E.1    Berg, L.2    Santini, F.3    Chopra, I.4    Hershman, J.M.5
  • 34
    • 34848892423 scopus 로고    scopus 로고
    • Thyrocyte-specific G(q)/G(11) deficiency impairs thyroid function and prevents goiter development
    • Kero J, et al. Thyrocyte-specific G(q)/G(11) deficiency impairs thyroid function and prevents goiter development. J Clin Invest. 2007;117(9):2399-2407.
    • (2007) J Clin Invest , vol.117 , Issue.9 , pp. 2399-2407
    • Kero, J.1
  • 35
    • 0037180426 scopus 로고    scopus 로고
    • Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice
    • Marians RC, Ng L, Blair HC, Unger P, Graves PN, Davies TF. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002;99(24):15776-15781.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.24 , pp. 15776-15781
    • Marians, R.C.1    Ng, L.2    Blair, H.C.3    Unger, P.4    Graves, P.N.5    Davies, T.F.6
  • 36
    • 0037180569 scopus 로고    scopus 로고
    • Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland
    • Postiglione MP, et al. Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Proc Natl Acad Sci U S A. 2002;99(24):15462-15467.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.24 , pp. 15462-15467
    • Postiglione, M.P.1
  • 37
  • 38
    • 42249084123 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies
    • Nishimura M, Naito S. Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet. 2008;23(1):22-44.
    • (2008) Drug Metab Pharmacokinet , vol.23 , Issue.1 , pp. 22-44
    • Nishimura, M.1    Naito, S.2
  • 39
    • 0242267051 scopus 로고    scopus 로고
    • Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid stimulating hormone receptor
    • Moeller LC, Kimura S, Kusakabe T, Liao XH, Van Sande J, Refetoff S. Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid stimulating hormone receptor. Mol Endocrinol. 2003;17(11):2295-2003.
    • (2003) Mol Endocrinol , vol.17 , Issue.11 , pp. 2295-12003
    • Moeller, L.C.1    Kimura, S.2    Kusakabe, T.3    Liao, X.H.4    Van Sande, J.5    Refetoff, S.6
  • 40
    • 85003126219 scopus 로고
    • The bioassay of thyrotropin in serum
    • McKenzie J. The bioassay of thyrotropin in serum. Endocrinology. 1958;63(3):372-382.
    • (1958) Endocrinology , vol.63 , Issue.3 , pp. 372-382
    • McKenzie, J.1
  • 42
    • 0022406652 scopus 로고
    • Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function
    • Morreale de Escobar G, Pastor R, Obregon MJ, Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology. 1985;117(5):1890-1900.
    • (1985) Endocrinology , vol.117 , Issue.5 , pp. 1890-1900
    • Morreale De Escobar, G.1    Pastor, R.2    Obregon, M.J.3    Escobar Del Rey, F.4
  • 43
    • 0033396462 scopus 로고    scopus 로고
    • Improved radioimmunoassay for measurement of mouse thyrotropin in serum: Strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone
    • Pohlenz J, Weiss RE, Cua K, Van Sande J, Refetoff S. Improved radioimmunoassay for measurement of mouse thyrotropin in serum: Strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid. 1999;9(12):1265-1271.
    • (1999) Thyroid , vol.9 , Issue.12 , pp. 1265-1271
    • Pohlenz, J.1    Weiss, R.E.2    Cua, K.3    Van Sande, J.4    Refetoff, S.5
  • 44
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


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