Growth factors and goitrogenesis

Journal of Endocrinology

Volumn 160, Issue 3, 1999, Pages 321-332

  Bidey, S P ^a   Hill, D J ^b   Eggo, M C ^c,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; ATRIAL NATRIURETIC FACTOR; ENDOTHELIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; SOMATOMEDIN; THYROTROPIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ACROMEGALY; ANIMAL MODEL; CELL DIVISION; DISEASE ASSOCIATION; IODINE DEFICIENCY; NODULAR GOITER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REVIEW; THYROID FOLLICLE; THYROID GLAND; THYROID HYPERPLASIA;

EID: 0032947878     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1600321     Document Type: Review

References (123)

1. Abdullaeva ZhM, Zhukovskii MA & Kandror VI 1987 Characteristics of the endocrine function of the pancreas in diffuse toxic goiter in children. Problemy Endokrinologii 33 11-15.
2. Aeschimann S, Buergi U, Wagner HE, Kaempf J, Lauber K & Studer H 1994 Low intrathyroidal iodine concentration in non-endemic human goitres: a consequence rather than a cause of autonomous goitre growth. Journal of Endocrinology 140 155-164.
3. Ahmed A, Dunk C, Kniss D & Wilkes M 1997 Role of vascular endothelial growth factor and its receptor (Flt-1) in mediating calcium-dependent NO release and limiting DNA synthesis in human trophoblast cells. Laboratory Investigation 76 779-791.
4. Asmis LM, Kaempf J, Von Gruenigen C, Kimura ET, Wagner HE & Studer H 1996 Acquired and naturally occurring resistance of thyroid follicular cells to the growth inhibitory action of transforming growth factor beta 1 (TGF β1). Journal of Endocrinology 149 485-496.
5. Bachrach LK, Eggo MC, Hintz RL & Burrow GN 1988 Insulin like growth factors in sheep thyroid cells: action, receptors and production. Biochemical and Biophysical Research Communications 154 861-867.
6. Bachrach LK, Liu FR, Burrow GN & Eggo MC 1989 Characterization of insulin like growth factor binding proteins from sheep thyroid cells. Endocrinology 125 2831-2838.
7. Bachrach LK, Eggo MC, Burrow GN, Liu F, Tram T & Powell DR 1991 Regulation of insulin like growth factor binding protein messenger ribonucleic acid levels in sheep thyroid cells. Endocrinology 128 1967-1973.
8. Baldwin RL, Friess H, Yokoyama M, Lopez ME, Kobrin MS, Buchler MW & Korc M 1996 Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition. International Journal of Cancer 67 283-288.
9. Becks GP, Eggo MC & Burrow GN 1987 Iodide regulation of differentiated thyroid function: preferential inhibitory effect of excess iodide on thyroid hormone secretion in sheep thyroid cell cultures. Endocrinology 120 2569-2576.
10. Becks GP, Eggo MC & Burrow GN 1988 Organic iodine inhibits deoxyribonucleic acid synthesis and growth in FRTL 5 cells. Endocrinology 123 545-551.
11. Becks GP, Logan A, Phillips ID, Wang JF, Smith C, DeSousa D & Hill DJ 1994 Increase of basic FGF and FGF receptor mRNA during rat hyperplasia: temporal changes and cell distribution. Journal of Endocrinology 142 325-338.
12. Beere HM, Soden J, Tomlinson S & Bidey SP 1991 Insulin like growth factor I production and action in porcine thyroid follicular cells in monolayer: regulation by transforming growth factor β. Journal of Endocrinology 130 3-9.
13. Beere HM, Cowin AJ, Soden J & Bidey SP 1995 Iodide dependent regulation of thyroid follicular cell proliferation: a mediating role of autocrine insulin like growth factor I. Growth Regulation 5 203-209.
14. Bellon G, Chaquor B, Antonicelli F, Wegrwoski J, Claisse D, Haye B & Borel JP 1994 Differential expression of thrombospondin, collagen and thyroglobulin by TSH and tumour promoting phorbol esters in cultured porcine thyroid cells. Journal of Cellular Physiology 160 175-188.
15. Bidey SP 1990 The control of thyroid cell and follicle growth: recent advances and current controversies. Trends in Endocrinology and Metabolism 3 174-178.
16. Blaydes JP & Wynford Thomas D 1996 Loss of responsiveness to transforming growth factor beta (TGFβ) is tightly linked to tumorigenicity in a model of thyroid tumour progression. International Journal of Cancer 65 525-530.
17. Brenner-Gati L, Berg KA & Gershengorn MC 1988 Thyroid stimulating hormone and insulin like growth factor 1 synergize to elevate 1,2 diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems. Journal of Clinical Investigation 82 1144-1148.
18. Brown LF, Detmer M, Tognazzi K, Bbu-Jawdah G & Iruela-Arispe ML 1997 Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for VEGF. Laboratory Investigation 76 245-255.
19. Burikhanov R, Coulonval K, Pirson I, Lamy F, Dumont JE & Roger PP 1996 Thyrotropin via cyclic AMP induces insulin receptor expression and insulin co-stimulation of growth and amplifies insulin and insulin like growth factor signaling pathways in dog thyroid epithelial cells. Journal of Biological Chemistry 271 29400-29406.
20. Chanoine JP, Stein GS, Braverman LE, Shalhoub V, Linn JB, Huber CA & DeVito WJ 1992 Acidic FGF modulates gene expression in the rat thyroid in vivo. Journal of Cellular Biochemistry 50 392-399.
21. Cheung NW, Lou JC & Boyages SC 1996 GH does not increase thyroid size in the absence of thyrotropin: a study in adults with hypopituitarism. Journal of Clinical Endocrinology and Metabolism 81 1179-1183.
22. Coclet J, Foreau F, Ketelbant P, Galand P & Dumont JE 1989 Cell proliferation in dog and adult human thyroid. Clinical Endocrinology 31 655-665.
23. Colin IM, Berbinschi A, Denef JF & Ketelslegers JM 1992 Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells. Endocrinology 130 544-546.
24. Colin IM, Selvais PL, Rebai T, Maiter DM, Adam E, van den Hove MF, Ketelslegers JM & Denef JF 1994 Expression of the endothelin-1 gene in the rat thyroid gland and changes in its peptide and mRNA levels in goiter formation and iodide-induced involution. Journal of Endocrinology 143 65-74.
25. Colin IM, Nava E, Toussaint D, Maiter DM, van den Hove MF, Luscher TF, Ketelslegers JM, Denef JF & Jameson JL 1995 Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of NO in vascular control during goiter formation. Endocrinology 136 5283-5290.
26. Cowin AJ & Bidey SP 1994 Transforming growth factor-β1 synthesis in human thyroid follicular cells: differential effects of iodide and plasminogen on the production of latent and active peptide forms. Journal of Endocrinology 141 183-190.
27. Cowin AJ & Bidey SP 1995 Porcine thyroid follicular cells in monolayer culture activate the iodide responsive precursor form of transforming growth factor β1. Journal of Endocrinology 144 67-73.
28. Cowin AJ & Bidey SP 1996 Heterogeneity of transforming growth factor β1 (TGF β1) synthesis, activation and responsiveness profiles in thyroid follicular cell cultures derived from human multinodular nontoxic goitres. Journal of Endocrinology 151 (suppl) P103.
29. Cowin AJ, Davis JRE & Bidey SP 1992 Transforming growth factor β1 production in porcine thyroid follicular cells: regulation by intrathyroidal organic iodine. Journal of Molecular Endocrinology 9 197-205.
30. Cowin AJ, Heaton EL, Cheshire SH & Bidey SP 1996 The proliferative responses of porcine thyroid follicular cells to epidermal growth factor and thyrotrophin reflect the autocrine production of transforming growth factor β1. Journal of Endocrinology 148 87-94.
31. Cui W, Fowlis DJ, Cousins FM, Duffie E, Bryson S, Balmain A & Akhurst RJ 1995 Concerted action of TGF-β1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Genes and Development 9 945-955.
32. DeVito WJ, Chanoine JP, Alex S, Fang SL, Stone S, Huber AC, Shalhoub V, Linn JB, Stein GS & Braverman LE 1992 Effect of in vivo administration of recombinant acidic FGF on thyroid function in the rat: induction of colloid goitre. Endocrinology 131 729-735.
33. Di Renzo MF, Narsimhan RP, Olivero M, Bretti S, Giordano S, Medico E, Gaglia P, Zara P & Comoglio PM 1991 Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene 6 1997-2003.
34. Dremier S, Taton M, Coulonval K, Nakamura T, Matsumoto K & Dumont JE 1994 Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells. Endocrinology 135 135-140.
35. Dugrillon A, Uedelhoven WM, Pisarev MA, Bechtner G & Gärtner R 1994 Identification of d-Iodolactone in iodide treated human goiter and its inhibitory effect on proliferation of human thyroid follicles. Hormone and Metabolic Research 26 465-469.
36. Dumont JE, Maenhaut C, Pirson I, Baptist M & Roger PP 1991 Baillière's Clinical Endocrinology and Metabolism 5 727-754.
37. Eccles N, Ivan M & Wynford Thomas D 1996 Mitogenic stimulation of normal and oncogene transformed human thyroid epithelial cells by hepatocyte growth factor. Molecular and Cellular Endocrinology 117 247-251.
38. Eggo MC 1998 Thyroid follicular cells. In Endocrine Cell Culture, pp 109-133. Ed. SP Bidey. Cambridge: Cambridge University Press.
39. Eggo MC & Sheppard MC 1994 Autocrine growth factors produced in the thyroid. Molecular and Cellular Endocrinology 100 97-102.
40. Eggo MC, Mak WW, Bachrach LK, Errick JE & Burrow GN 1985 Cultured thyroids: is immortality the answer? In Thyroglobulin: The Prothyroid Hormone, pp 201-210. Eds MC: Eggo & GN Burrow. New York: Raven.
41. Eggo MC, Pratt MAC, Becks GP & Burrow GN 1989 Regulation of growth and differentiation in thyroid follicle cells. Advances in Experimental Biology and Medicine 261 341-356.
42. Eggo MC, Bachrach LK & Burrow GN 1990 Interaction of TSH, insulin and insulin like growth factors in regulating thyroid growth and function. Growth Factors 2 99-109.
43. Eggo MC, Bachrach LK, Brown AL & Burrow GN 1991 Thyrotropin inhibits while insulin, epidermal growth factor and tetradecanoyl phorbol acetate stimulate insulin like growth factor binding protein secretion from sheep thyroid cell. Growth Factors 4 221-230.
44. Eggo MC, King W, Black EG & Sheppard MC 1996 Functional human thyroid cells and their insulin like growth factor binding proteins: regulation by thyrotropin, cyclic 3′5′-adenosine monophosphate and growth factors. Journal of Clinical Endocrinology Metabolism 81 3056-3062.
45. Eguchi K, Kawakami A, Nakashima M, Ida H, Sakito S, Sakai M, Terada K, Kawabe Y, Fukuda T & Ishikawa N 1993 Stimulation of mitogenesis in human thyroid epithelial cells by endothelin. Acta Endocrinologica 128 215-220.
46. Emoto N, Isozaki O, Arai M, Murakami H, Shizume K, Baird A, Tshushima T & Demura H 1991 Identification and characterisation of basic FGF in porcine thyroid. Endocrinology 128 58-64.
47. Ewen ME, Skuss HK, Whithouse LL & Livingston DM 1993 TGF β inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 260 536-539.
48. Geng Y & Weinberg RA 1993 Transforming growth factor β effects on expression of G1 cyclins and cyclin dependent protein kinases. Proceedings of the National Academy of Sciences of the USA 90 10315-10319.
49. Gerard CH, Roger PP & Dumont JE 1989 Thyroglobulin gene expression as a differentiation marker in primary cultures of calf thyroid. Molecular and Cellular Endocrinology 61 23-35.
50. Gold LI, Saxena B, Mittal KR, Marmor M, Goswami S, Nactigal L, Korc M & Demopoulos RI 1994 The increased expression of transforming growth factor beta isoforms and basic fibroblast growth factor in complex hyperplasia and adenocarcinoma of the endometrium: evidence for paracrine and autocrine action. Cancer Research 54 2347-2358.
51. Goodman AL & Rone JD 1987 Thyroid angiogenesis: endotheliotropic chemoattractant activity from rat thyroid cells in culture. Endocrinology 121 2131-2140.
52. Greil W, Rafferzeder M, Bechtner G & Gartner R 1989 Release of an endothelial cell growth factor from cultured porcine thyroid follicles. Molecular Endocrinology 3 858-867.
53. Grübeck-Loebenstein B, Buchan G, Sadeghi R, Kissonerghis M, Londei M, Turner M, Pirich K, Roka R, Niederle B, Kassal H, Waldhausl W & Feldmann M 1989 Transforming growth factor β regulated thyroid growth: role in pathogenesis of non toxic goitre. Journal of Clinical Investigation 83 764-770.
54. Gutekunst R & Scriba PC 1989 Goitre and iodine deficiency in Europe: the ETA report as updated in 1988. Journal of Endocrinological Investigation 12 209-215.
55. Hanneken A, Ying WB, Ling N & Baird A 1994 Identification of soluble forms of the fibroblast growth factor receptor in blood. Proceedings of the National Academy of Sciences of the USA 91 9170-9174.
56. Hill DJ, Phillips ID, Wang JF & Becks GP 1994 Basic FGF in isolated ovine thyroid follicles: TSH stimulation and effects of bFGF on DNA synthesis, and the release of IGFs and IGFBPs. Thyroid 4 77-85.
57. Hofbauer LC, Rafferzeder M, Janssen EE & Gärtner R 1995 Insulin like growth factor 1 messenger ribonucleic acid expression in porcine thyroid follicles is regulated by thyrotropin and iodine. European Journal of Endocrinology 132 605-610.
58. Isozaki O, Tsushima T, Miyakawa M, Emoto N, Demura H, Sato Y, Shizume K & Arai M 1993 Iodine regulation of endothelin-1 gene expression in cultured porcine thyroid cells: possible involvement in autoregulation of the thyroid. Thyroid 3 239-244.
59. Kim DH & Kim SJ 1996 Transforming growth factor β receptors: role in physiology and disease. Journal of Biomedical Sciences 3 143-158.
60. Koff A, Ohtsuki M, Polyak K, Roberts JM & Massagué J 1993 Inhibition of cyclin E dependent kinase by TGF β. Science 74 1009-1020.
61. Kopp P, Kimura ET, Aeschimann D, Oestreicher M, Tobler A, Fey MF & Studer H 1994 Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters. Journal of Clinical Endocrinology and Metabolism 79 134-139.
62. Kurihara Y, Kuirhara H, Maemura K, Kuwaki T, Kumada M & Yazaki Y 1995 Impaired development of the thyroid and thymus in endothelin-1 knock out mice. Journal of Cardiovascular Pharmacology 26 (Suppl 3) S13-S16.
63. Liu G, Takano T & Amino N 1996 TGF beta 1 inhibits the cell proliferation stimulated by IGF I by blocking the tyrosine phosphorylation of 175 kDa substrate. Endocrine Research 22 277-287.
64. Logan A, Black EG, Gonzalez AM, Buscaglia M & Sheppard MC 1992 basic FGF: an autocrine mitogen of rat thyroid follicular cells. Endocrinology 130 2363-2372.
65. Logan A, Smith G, Becks GP, Gonzalez AM, Phillips ID & Hill DJ 1994 Enhanced expression of transforming growth factor β1 during thyroid hyperplasia in rats. Journal of Endocrinology 141 45-57.
66. Maiorano E, Ambrosi A, Giorino R, Fersini M, Pllice L & Ciampolillo A 1994 IGF-I in multinodular goiter: a possible pathogenic factor. Pathology Research and Practice 190 1012-1016.
67. Mak WW, Eggo MC & Burrow GN 1984 Thyrotropin regulation of plasminogen activator activity in primary cultures of ovine thyroid cells. Biochemical and Biophysical Research Communications 123 633-640.
68. Mak WW, Bhaumick B, Bala RMY, Kudlow JE, Eggo MC & Burrow GN 1985 Possible role of insulin-like growth factors in the regulation of thyroid growth. ICSU Short Reports 4 50-51.
69. Michell NP, Dent S, Langman MJS & Eggo MC 1997 IGFBPs as mediators of IGF-I effects on colon cancer cell proliferation. Growth Factors 14 269-277.
70. Minuto F, Barreca A, Del Monte P, Cariola G, Torre GC & Giordano G 1989 Immunoreactive insulin like growth factor I (IGF I) and IGF I binding protein content in human thyroid tissue. Journal of Clinical Endocrinology and Metabolism 68 621-627.
71. Miyakawa M, Tsushima T, Isoraki O, Demura H, Shizume K & Arai M 1992 Endothelin-1 stimulates c-fos mRNA expression and acts as a modulator on cell proliferation of rat FRTL5 thyroid cells. Biochemical and Biophysical Research Communications 184 231-238.
72. Morosini P, Taccaliti A, Arnaldi G, Simonella G, Petrelli MD, Mancini V, Montironi R & Scarpelli M 1996 Enhanced expression of transforming growth factor β1 in rat thyroid hyperplasia is thyrotropin induced and time dependent. European Journal of Endocrinology 134 373-378.
73. Morris JC, Ranganathan G, Hay ID, Nelson RE & Jiang NS 1988 The effects of transforming growth factor β on the growth and differentiation of the continuous rat thyroid follicular cell line FRTL 5. Endocrinology 123 1385-1394.
74. Ogasawara M, Karey KP, Marquadt H & Sirbasku DA 1989 Identification and purification of truncated IGF-I from porcine uterus. Evidence for high biological potency. Biochemistry 28 2710-2721.
75. Ollis CA, Hill DJ & Munro DS 1989 A role for insulin like growth factor I in the regulation of human thyroid cell growth by thyrotrophin. Journal of Endocrinology 123 495-500.
76. Ortiz L, Zannini M, DiLauro R & Santisteban P 1997 Transcriptional control of the forkhead thyroid transcriptional factor TTF-2 by TSH, insulin and IGF-I. Journal of Biological Chemistry 272 23334-23339.
77. Patel VA, Hill DJ, Eggo MC, Sheppard MC, Becks GP & Logan A 1996 Changes in the immunohistochemical localisation of FGF-2, TGFβ1 and thrombospondin-1 are associated with the early angiogenic events in the hyperplastic rat thyroid. Journal of Endocrinology 148 185-199.
78. Pedram A, Razandi M, Hu RM & Levin ER 1997 Vasoactive peptides modulate VEGF production and endothelial cell proliferation and invasion. Journal of Biological Chemistry 272 17097-17106.
79. Pekary AE, Berg L, Wang J, Lee P, Dubinett SM & Hershmann JM 1995 TNF alpha, TSH and ageing regulate TGF β synthesis and secretion in FRTL 5 rat thyroid cells. American Journal of Physiology 268 R808-R815.
80. Perlino E, Ciampollino A, Maiorano E, Pannone E, Viale G, Giorigno R & Marra E 1996 Transforming growth factor beta 1 (TGF β1) expression in proliferating thyroid disease. International Journal of Oncology 9 83-88.
81. Perrotti N, Rotella CM, Alvarez FV, Kohn LD & Taylor S 1989 Characterization of receptors for insulin and insulin like growth factor I on FRTL 5 thyroid cells. Advances in Experimental Medicine and Biology 261 105-119.
82. Phillips ID, Black EG, Sheppard MC & Docherty K 1989 Thyrotrophin, forskolin and ionomycin increase cathepsin B mRNA concentrations in rat thyroid cells in culture. Journal of Molecular Endocrinology 2 207-212.
83. Phillips ID, Becks, GP, Logan A, Wang JF, Smith C & Hill DJ 1994 Altered expression of IGF-I and IGFBPs during rat thyroid hyperplasia and involution. Growth Factors 10 207-222.
84. Pisarev MA, Krawiec L, Juvenal GJ, Bocanera LV, Pregliasco LB, Sartorio G & Chester HA 1994 Studies on the goiter inhibiting action of iodolactones. European Journal of Pharmacology 258 33-37.
85. Prabakaran D, Kim P, Kim KR & Arvan P 1993 Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells. Journal of Biological Chemistry 268 9041-9048.
86. Roberts AB 1998 Molecular and cell biology of transforming growth factor-beta. Mineral and Electrolyte Metabolism 24 111-119.
87. Roger PP & Dumont JE 1984 Factors controlling proliferation and differentiation in canine thyroid cells cultured in reduced serum conditions: effects of TSH, cAMP and growth factors. Molecular and Cellular Endocrinology 36 79-93.
88. Saji M & Kohn LD 1991 Insulin and insulin like growth factor I inhibit thyrotropin increased iodide transport in serum depleted FRTL 5 rat thyroid cells: modulation of adenosine 3′,5′ monophosphate signal action. Endocrinology 128 1136-1143.
89. Saji M, Akamizu T, Sanchez M, Obici S, Avvedimento E, Gottesman ME & Kohn LD 1992 Regulation of thyrotropin receptor gene expression in rat FRTL 5 thyroid cells. Endocrinology 130 520-533.
90. Santisteban P, Kohn LD & Di Lauro R 1987 Thyroglobulin gene expression is regulated by insulin and insulin like growth factor I, as well as thyrotropin, in FRTL 5 thyroid cells. Journal of Biological Chemistry 262 4048-4052.
91. Santisteban P, Acebron A, Polycarpou Schwarz M & Di Lauro R 1992 Insulin and insulin like growth factor I regulate a thyroid specific nuclear protein that binds to the thyroglobulin promoter. Molecular Endocrinology 6 1310-1317.
92. Sato K, Yamazaki K, Shizume K, Kanaji Y, Obara T, Ohsumi K, Demura H, Yamaguchi S & Shibuya M 1995 Stimulation by thyroid-stimulating hormone and Graves' immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo. Journal of Clinical Investigation 96 1295-1302.
93. Sato K, Miyakawa M, Onoda N, Demura H, Yamashita T, Miura M, Kasajima T, Yamazaki K & Obara T 1997 Increased concentrations of vascular endothelial growth factor/vascular permeability factor in cyst fluid of enlarging and recurrent thyroid nodules. Journal of Clinical Endocrinology and Metabolism 82 1968-1973.
94. Sellitti DF & Hughes C 1990 Immunoreactive atrial natriuretic peptide in the thyroid gland. Regulatory Peptides 27 285-298.
95. Sellitti DF, Tseng YC & Wartofsky L 1989 Receptors for atrial natriuretic peptide (ANP) and regulation of thyroglobulin secretion by ANP in human thyroid cells. Life Science 45 793-801.
96. Stathakis P, Fitzgerald M, Matthias LJ, Chesterman CN & Hogg PJ 1997 Generation of angiostatin by reduction and proteolysis of plasmin. Journal of Biological Chemistry 272 20641-20645.
97. Studer H, Gerber H, Zbaeren J & Peter HJ 1992 Histomorphological and immunohistochemical evidence that human nodular goitres grow by episodic replication of multiple clusters of thyroid follicular cells. Journal of Clinical Endocrinology and Metabolism 75 1151-1158.
98. Studer H, Peter HJ & Gerber H 1995 Natural heterogeneity of thyroid cells: the basis for understanding thyroid function and nodular growth. Endocrine Reviews 10 125-135.
99. Takahashi S, Conti M, Prokop C, Van Wyk JJ & Earp HS 1991 Thyrotropin and insulin like growth factor I regulation of tyrosine phosphorylation in FRTL 5 cells. Interaction between cAMP dependent and growth factor dependent signal transduction. Journal of Biological Chemistry 266 7834-7841.
100. Taton M, Lamy F, Roger PP & Dumont JE 1993 General inhibition by TGFβ of TSH and cAMP responses in human thyroid cells. Molecular and Cellular Endocrinology 95 13-21.
101. Taylor AH, Millat G, Whitley St J, Johnstone AP & Nussey SS 1993 The effects of FGF on growth and function of human thyrocytes. Journal of Endocrinology 136 339-344.
102. Thomas GA, Williams D & Williams ED 1988 The demonstration of tissue clonality by X-linked enzyme histochemistry. Journal of Pathology 155 101-108.
103. Thompson SD, Franklyn JA, Watkinson JC, Verhaeg JM, Sheppard MC & Eggo MG 1998 Fibroblast receptors 1 and 2 and FGF receptor 1 are elevated in thyroid hyperplasia. Journal of Clinical Endocrinology and Metabolism 83 1336-1341.
104. Timme TL, Truong LD, Slawin KM, Kasmon D, Sang Hee P & Thompson TD 1995 Mesenchymal epithelial interactions and transforming growth factor β1 expression during normal and abnormal prostatic growth. Microscopy Research and Technique 30 333-341.
105. Tode B, Serio M, Rotella CM, Galli G, Franceschelli F, Tanini A & Toccafondi K 1989 Insulin like growth factor I: autocrine secretion by human thyroid follicular cells in primary culture. Journal of Clinical Endocrinology and Metabolism 69 639-647.
106. Tramontano D, Moses AC, Picone R & Ingbar SH 1987 Characterization and regulations of the receptor for insulin like growth factor I in the FRTL 5 rat thyroid follicular cell line. Endocrinology 120 785-790.
107. Tramontano D, Veneziani BM, Lombardi A, Villone G & Ingbar SH 1989 Iodine inhibits the proliferation of rat thyroid cells in culture. Endocrinology 125 984-992.
108. Trovato M, Villari D, Bartolone L, Spinella S, Simone A, Violi MA, Trimarchi F, Batolo D & Benvenga S 1998 Expression of the hepatocyte growth factor and c-met in normal thyroid, non-neoplastic and neoplastic nodules. Thyroid 8 125-131.
109. Tseng YC, Lahiri S, Sellitti DF, Burman KD, D'Avis JC & Wartofsky L 1990 Characterisation by affinity cross-linking of a receptor for ANP in cultured human thyroid cells associated with reductions in both adenosine 3′,5′-monophosphate production and thyroglobulin secretion. Journal of Clinical Endocrinology and Metabolism 70 528-533.
110. Tseng YL, Burman KD, Lahin S, Abdelrahim MM, D'Avis JC & Wartofsky L 1991 TSH modulates receptor-mediated processing of the atrial natriuretic peptide receptor in cultured thyroid cells. Journal of Clinical Endocrinology and Metabolism 72 669-674.
111. Tseng YC, Lahiri S, Jackson S, Burman KD & Wartofsky L 1993 Endothelin binding to receptors and endothelin production by human thyroid follicular cells: effects of TGFβ and TSH. Journal of Clinical Endocrinology and Metabolism 76 156-161.
112. Tsushima T, Arai M, Saji M, Ohba Y, Murakami H, Ohmura E, Sato K & Shizume K 1988 Effects of transforming growth factor β on deoxyribonucleic acid synthesis and iodine metabolism in porcine thyroid cells in culture. Endocrinology 123 1187-1194.
113. Tsushima T, Arai M, Isozaki O, Nozoe Y, Shizume K, Murakami H, Emoto N, Miyakawa M & Demura H 1994 Interaction of endothelin-1 with porcine thyroid cells in culture: a possible autocrine factor regulating iodine metabolism. Journal of Endocrinology 142 463-470.
114. Vainio M, Saijonmaa O, Fyrhrquist F & Tornquist K 1996 Purinergic agonists stimulate the secretion of endothelin in rat thyroid FKTL5 cells. Journal of Cellular Physiology 169 538-543.
115. Viglietto G, Romano A, Manzo G, Chiappetta G, Paoletti I, Califano D, Galati MG, Mauriello V, Bruni P, Lago CT, Fusco A & Persico MG 1997 Upregulation of the angiogenic factor P1GF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in the thyroid gland of thiouracil-fed rats suggests a TSH-dependent paracrine mechansim for goiter hypervascularization. Oncogene 15 2687-2698.
116. Wang JF, Becks GP, Hanada E, Buckingham KD, Phillips ID & Hill DJ 1991 Hormonal regulation of insulin like growth factor (IGF) binding proteins secreted by isolated sheep thyroid epithelial cells: relationship with iodine organisation. Journal of Endocrinology 130 129-140.
117. Wang JF, Milosveski V, Schramek C, Fong GH, Becks GP & Hill DJ 1998 Presence and possible role of vascular endothelial growth factor in thyroid cell growth and function. Journal of Endocrinology 157 5-12.
118. Wheeler MH 1994 The solitary thyroid nodule. In Diseases of the Thyroid: Pathophysiology and Management, pp 231-244. Eds MH Wheeler & JH Lazarus. London: Chapman & Hall.
119. Williams DW, Williams ED & Wynford-Thomas DW 1988 Loss of dependence for proliferation of human thyroid adenoma. British Journal of Cancer 57 535-539.
120. Wollman SH, Herveg JP, Zeligs JD & Ericson LE 1978 Blood capillary enlargement during the development of thyroid hyperplasia in the rat. Endocrinology 103 2306-2312.
121. Wuster C, Steger G, Schmelzle A, Gottswinter J, Mine HW & Zeigler R 1991 Increased incidence of euthyroid and hypertbyroid goiter independent of thyrotropin in patients with acromegaly. Hormone and Metabolic Research 23 13101-13134.
122. Yamamoto K, Hirai A, Ban T, Saito J, Tahara K, Terano T, Tamura Y, Saito Y & Kitagawa M 1996 Thyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin like growth factor I stimulation in FRTL 5 cells Endocrinology 137 2036-2042.
123. Yuasa R, Eggo MC, Meinkoth J, Dillman WH & Burrow GN 1992 Iodide induces transforming growth factor β1 (TGF β1) mRNA in sheep thyroid cells. Thyroid 2 141-145.