Synthesis and biological evaluation of 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as a novel class of potential anti-tumor agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 2776-2781

  Ibrahim, D A ^a  

^a NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

Author keywords

1,2,4 Triazolo 3,4 d 1,3,4 thiadiazole; Alkylation; Amination; Anti tumor; Cyclization

Indexed keywords

2 AMINO 5 [(3 BENZYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) METHYL] 1,3 THIAZOL 4 OL; 2 AMINO 5 [(3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) METHYL] 1,3 THIAZOL 4 OL; 3 [(3 BENZYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) METHYL] 1H PYRAZOLO[3,4 D] PYRAMIDINE 4,6 DITHIONE; 3 [(3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) METHYL] 1H PYRAZOLO[3,4 D] PYRAMIDINE 4,6 DITHIONE; 3 [(4 CHLOROPHENOXY)METHYL 6 [3 [(4 CHLOROPHENOXY)METHYL][1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL]DITHIO][1,2,4] TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 [(4 CHLOROPHENOXY)METHYL] 6 (ETHYLTHIO)[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 3 [(4 CHLOROPHENOXY)METHYL] 6 HYDRAZINO[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 3 [(4 CHLOROPHENOXY)METHYL][1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE 6 THIOL; 3 [3 [(4 CHLOROPHENOXY)METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL] METHYL] 1H PYRAZOLO[3,4 D] PYRAMIDINE 4,6 DITHIONE; 3 BENZYL 6 (BENZYLTHIO)[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 3 BENZYL 6 (ETHYLTHIO)[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 3 BENZYL 6 [(3 BENZYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL)DITHIO][1,2,4] TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 BENZYL 6 HYDRAZINO[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 3 METHYL 6 [(3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL)DITHIO][1,2,4] TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; 3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE 6 THIOL; 4 (3 BENZYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) ANILINE; 4 (3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL) ANILINE; 4 [3 (4 CHLOROPHENOXY)METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOL 6 YL] ANILINE; 6 (BENZYLTHIO) 3 [(4 CHLOROPHENOXY)METHYL][1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 6 (BENZYLTHIO) 3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 6 (ETHYLTHIO) 3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; 6 HYDRAZINO 3 METHYL[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZOLE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, NUDE; THIADIAZOLES; TRIAZOLES;

EID: 67349255332     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.01.003     Document Type: Article

References (13)

1. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watenabe S., Itoh N., Shibuya M., and Fukami Y. J. Biol. Chem. 262 (1987) 5592-5595
2. Graziani Y., Erikson E., and Erikson R.L. Eur. J. Biochem. 135 (1983) 583-589
3. Cushman M., Nagarathnam D., Burg D.L., and Geahlen R.L. J. Med. Chem. 34 (1991) 798-806
4. Cunninghan B.D.M., Threadgill M.D., Groundwater P.W., Dale I.L., and Hickman J.A. Anti-Cancer Drug Des. 7 (1992) 365-384
5. Gullick W.J. Br. Med. Bull. 47 (1991) 87-98
6. Yarden Y., and Ullrich A. Annu. Rev. Biochem. 57 (1988) 443-478
7. Yates P.C., Mccall C.J., and Stevens M.F.G. Tetrahedron 47 (1991) 6493-6502
8. Kuangsen S., and An-Rong L. J. Heterocycl. Chem. 29 (1992) 1101-1105
9. Parmar S.S., Gupta A.K., Singh H.H., and Gupta T.K. J. Med. Chem. 15 (1972) 999-1006
10. Trivedi J.P., Contractor S.J., and Shah I.D. J. Indian Chem. Soc. 43 (1966) 265-268
11. Skehan P., Scudiero D., et al. J. Natl. Cancer Inst. 82 (1990) 1107-1111
12. Grever M.R., Schepartz S.A., and Chabner B.A. Semin. Oncol. 19 (1992) 622-638
13. Boyd M.R., and Paul K.D. Drug Dev. Res. 34 (1995) 91-98