Synthesis and antitumor activity of novel pyrido[2,3-d][1,2,4]triazolo[4,3- a]pyrimidin-5-one derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2031-2036

  El Nassan, Hala B ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Antitumor activity; MCF7; Pyrido 2,3 d 1,2,4 triazolo 4,3 a pyrimidin 5 one; Pyrido 2,3 d pyrimidin 4 one

Indexed keywords

2 (4 CHLOROPHENYL)METHYLENEHYDRAZONE 5 (4 CHLOROPHENYL)7 PHENYLPYRIDO[2,3 DEXTRO]PYRIMIDIN 4(3H) ONE; 2 ARYLMETHYLENEHYDRAZONE 5 (4 CHLOROPHENYL) 7PHENYLPYRIDO[2,3 DEXTRO]PYRIMIDIN 4(3H) ONE; 2 HYDRAZINOPYRIDO[2,3 DEXTRO]PYRIMIDIN 4(3H) ONE; 3 AMINO 6 (4 CHLOROPHENYL) 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 3 BENZYLSULPHANYL 6 (4 CHLOROPHENYL) LEVO 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 3 CHLOROMETHYL 6 (4 CHLOROPHENYL) 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 5 (4 CHLOROPHENYL) 2 (3 NITROPHENYL)METHYLENEHYDRAZONE 7 PHENYLPYRIDO[2,3 DEXTRO]PYRIMIDIN 4(3H) ONE; 5 (4 CHLOROPHENYL) 2,3 DIHYDRO 7 PHENYL 2 THIOXOPYRIDO[2,3 DEXTRO]PYRIMIDIN 4(1H) ONE; 6 (4 CHLOROPHENYL) 3 (3 NITROPHENYL) 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 6 (4 CHLOROPHENYL) 3 ETHYLSULPHANYL 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 6 (4 CHLOROPHENYL) 3 METHYL 8 PHENYL 1H PYRIDO[2,3 DEXTRO] [1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 6 (4 CHLOROPHENYL) 3 METHYLSULPHANYL 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 6 (4 CHLOROPHENYL) 3,8 DIPHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5 ONE; 6 (4 CHLOROPHENYL) 5 OXO 8 PHENYL 1H PYRIDO[2,3 DEXTRO] [1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 3(2H) THIONE; 6 (4 CHLOROPHENYL) 8 PHENYL 1H PYRIDO[2,3 DEXTRO] [1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 3,5(2H) DIONE; ETHYL [6 (4 CHLOROPHENYL) 5 OXO 8 PHENYL 1H PYRIDO[2,3 DEXTRO][1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 3 YLSULPHANYL] ACETATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PYRIMIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79955573099     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.055     Document Type: Article

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