Transcriptional regulation of topoisomerase IIα at confluence and pharmacological modulation of expression by bis-benzimidazole drugs

Molecular Pharmacology

Volumn 59, Issue 4, 2001, Pages 699-706

  Tolner, Berend ^b   Hartley, John A ^a,b   Hochhauser, Daniel ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BENZIMIDAZOLE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); HOE 33342;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL PROLIFERATION; CHEMOSENSITIVITY; DEREGULATION; GENE EXPRESSION; MODULATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; TRANSCRIPTION REGULATION;

EID: 0035056991     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.4.699     Document Type: Article

References (37)

1. Cell-cycle regulation of the DNA topoisomerase promoter is mediated by proximal CCAAT boxes: Possible involvement of acetylation
2. DNA binding specificity of the CCAAT-binding factor CBF/NF-Y
3. Physico-chemical study of the complexes of "33258 Hoechst" with DNA and nucleohistone
4. c-Myb trans-activates the human DNA topoisomerase IIα gene promoter
5. Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
6. Ras stimulates DNA topoisomerase II alpha through MEK: A link between oncogenic signaling and a therapeutic target
7. DNA minor groove-binding ligands: A different class of mammalian DNA topoisomerase I inhibitors
8. Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins
9. Multicellular resistance: A paradigm for clinical resistance?
10. Confluence-dependent resistance in human colon cancer cells: Role of reduced drug accumulation and low intrinsic chemosensitivity of resting cells
11. Evidence for repressional role of an inverted CCAAT box in cell cycle-dependent transcription of the human DNA topoisomerase II alpha gene
12. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
13. Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines
14. The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase II alpha gene by heat shock
15. Higher expression of topoisomerase II in lung cancers than normal lung tissues: Different expression pattern from topoisomerase I
16. Cloning and characterization of the 5′-flanking region of the human topoisomerase IIα gene
17. ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression
18. The distribution of immunoreactive topoisomerase II protein in human tissues and neoplasms
19. Regulation of the human topoisomerase IIα gene promoter in confluence-arrested cells
20. mRNA expression of topoisomerase II in human tumors and normal tissues
21. GC base recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropyl-ethylenediaminetetraacetate-iron(II) footprinting studies
22. Dominant negative analogs of NF-YA
23. Induction of apoptosis by deregulated expression of DNA topoisomerase IIalpha
24. Down-regulation of topoisomerase II alpha in CEM cells selected for merbarone resistance is associated with reduced expression of Sp3
25. Sequence-selective DNA recognition by synthetic ligands
26. The multilayered postconfluent cell culture as a model for drug screening
27. Differential expression of the topoisomerase II alpha and beta genes in human breast cancers
28. P53 regulates the minimal promoter of the human topoisomerase II alpha gene
29. Bis-benzimidazole anticancer agents: Targeting human tumor helicases
30. Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells
31. Drug resistance mediated by cellular stress response to the microenvironment of solid tumors
32. The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues
33. DNA topoisomerases
34. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor
35. Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target
36. p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor
37. Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level