Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 8, 2002, Pages 2589-2596

  Göker, Hakan ^a,b   Kuş, Canan ^a   Boykin, David W ^b   Yildiz, Sulhiye ^a   Altanlar, Nurten ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 2 (4 FLUOROPHENYL) 1H BENZIMIDAZOLE 5 CARBOXAMIDE; 1 BUTYL 2 (4 FLUOROPHENYL) 1H BENZIMIDAZOLE 5 CARBOXYLIC ACID; 1 BUTYL 2 PHENYL 1H BENZIMIDAZOLE 5 CARBOXALDEHYDE; 5 CYANO 2 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 1H BENZIMIDAZOLE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ETHYL 1 PROPYL 2 PHENYL 1H BENZIMIDAZOLE 5 CARBOXYLATE; FLUCONAZOLE; MICONAZOLE; N ISOPROPYL 1 PROPYL 2 PHENYL 1H BENZIMIDAZOLE 5 CARBOXAMIDE; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE; NITRILE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; BACTERIUM; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANDIDA;

ANTIFUNGAL AGENTS; BACTERIA; BENZIMIDAZOLES; CANDIDA; MICROBIAL SENSITIVITY TESTS; NITRILES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036280357     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00103-7     Document Type: Article

References (21)

1. Laboratory studies with antifungal agents: Susceptibility tests and quantitation in body fluids