DOI 10.1016/j.bmcl.2005.11.008, PII S0960894X05014253
M.L. Boys, L.A. Schretzman, N.S. Chandrakumar, M.B. Tollefson, S.B. Mohler, V.L. Downs, T.D. Penning, M.A. Russell, J.A. Wendt, and B.B. Chen Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists Bioorg. Med. Chem. Lett. 16 2006 839 844 (Pubitemid 43059834)
3- and α-amino acids from Fmoc-protected aspartic acid
A. Hamzé, J.F. Hernandez, P. Fulcrand, and J. Martinez Synthesis of various 3-substituted 1,2,4-oxadiazole-containing chiral β3- and α-amino acids from Fmoc-protected aspartic acid J. Org. Chem. 68 2003 7316 7321 (Pubitemid 37122480)
The selective 5-HT(1B) receptor inverse agonist 1-methyl-5-[[2'-methyl- 4'(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7- tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo
DOI 10.1021/jm970457s
L.M. Gaster, F.E. Blaney, S. Davies, D.M. Duckworth, P. Ham, S. Jenkins, A.J. Jennings, G.F. Joiner, F.D. King, and K.R. Mulholland The selective 5-HT1B receptor inverse agonist 1′-Methyl-5-[[2′-methyl-4′- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4′-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo J. Med. Chem. 41 1998 1218 1235 (Pubitemid 28208177)
T. Suzuki, K. Iwaoka, N. Imanishi, Y. Nagakura, K. Miyata, H. Nakahara, M. Ohta, and T. Mase Synthesis of the Selective 5-Hydroxytryptamine 4 (5-HT4) Receptor Agonist (+)-(S)-2-Chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1, 2, 4-oxadiazol-3-yl] aniline Chem. Pharm. Bull. 47 1999 120 122 (Pubitemid 29078744)
Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1'-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1'-substituted- acetoxymethyl)-2-dioxolanyl] dialkyl amines
DOI 10.1016/S0968-0896(00)00092-4, PII S0968089600000924
S. Manfredini, I. Lampronti, S. Vertuani, N. Solaroli, M. Recanatini, D. Bryan, and M. McKinney Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1′-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1′-substituted-acetoxymethyl)-2-dioxolanyl] dialkyl amines Bioorg. Med. Chem. 8 2000 1559 1566 (Pubitemid 30427223)
Synthesis and use of 5-vinyl-1,2,4-oxadiazoles as Michael acceptors. A rapid synthesis of the potent muscarinic agonist L-670,548
DOI 10.1021/jo9603340
J.E. Macor, T. Ordway, R.L. Smith, P.R. Verhoest, and R.A. Mack Synthesis and use of 5-vinyl-1,2,4-oxadiazoles as michael acceptors. A rapid synthesis of the potent muscarinic agonist L-670,548 J. Org. Chem. 61 1996 3228 3229 (Pubitemid 26189012)
Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors
J.B. Acri, G. Wong, and J.M. Witkin Stereospecific transduction of behavioral effects via diazepam-insensitive GABAA receptors Eur. J. Pharmacol. 278 1995 213 223
Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats
N.A. Ator, and R.R. Griffiths Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats J. Pharmacol. Exp. Ther. 289 1999 1434 1446 (Pubitemid 29246675)
Synthesis and biological evaluation of several coumarin-4- carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives
DOI 10.1016/S0223-5234(98)80030-5
D.N. Nicolaides, K.C. Fylaktakidou, K.E. Litinas, and D. Hadjipavlou-Litina Synthesis and biological evaluation of several coumarin-4-carboxamidoxime and 3-(coumarin-4-yl)-1,2,4-oxadiazole derivatives Eur. J. Med. Chem. 33 1998 715 724 (Pubitemid 29161321)
A study of the biological pharmacology of IFO, a new selective and reversible monoamine oxidase-B inhibitor
J. Matsumoto, T. Takahashi, M. Agata, H. Toyofuku, and N. Sasada A study of the biological pharmacology of IFO, a new selective and reversible monoamine oxidase-B inhibitor Jpn. J. Pharmacol. 65 1994 51 57 (Pubitemid 24164653)
Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4- oxadiazoles as a new series of apoptosis inducers and potential anticancer agents
DOI 10.1021/jm050292k
H.Z. Zhang, S. Kasibhatla, J. Kuemmerle, W. Kemnitzer, K. Ollis-Mason, L. Qiu, C. Crogan-Grundy, B. Tseng, J. Drewe, and S.X. Cai Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents J. Med. Chem. 48 2005 5215 5223 (Pubitemid 41113908)
Synthesis and cytotoxic profile of glycosyl-triazole linked to 1,2,4-oxadiazole moiety at C-5 through a straight-chain carbon and oxygen atoms
J.V. dos Anjos, R.A.W. Neves Filho, S.C. do Nascimento, R.M. Srivastava, S.J. de Melo, and D. Sinou Synthesis and cytotoxic profile of glycosyl-triazole linked to 1,2,4-oxadiazole moiety at C-5 through a straight-chain carbon and oxygen atoms Eur. J. Med. Chem. 44 2009 3571 3576
Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents
W. Kemnitzer, J. Kuemmerle, H.Z. Zhang, S. Kasibhatla, B. Tseng, J. Drewe, and S.X. Cai Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents Bioorg. Med. Chem. Lett. 19 2009 4410 4415
Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4- oxadiazoles
D. Kumar, G. Patel, E.O. Johnson, and K. Shah Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4-oxadiazoles Bioorg. Med. Chem. Lett. 19 2009 2739 2741
Beyond taxanes: A review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins
M. Harrison, K. Holen, and G. Liu Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins Clin. Adv. Hematol. Oncol. 7 2009 54 64
Pharmaceutical design of antimitotic agents based on combretastatins
DOI 10.2174/1381612053764751
H.P. Hsieh, J.P. Liou, and N. Mahindroo Pharmaceutical design of antimitotic agents based on combretastatins Curr. Pharm. Des. 11 2005 1655 1677 (Pubitemid 40668143)
Synthesis and spectral data of 4,5-bis[5-aryl-1,3,4-oxadiazol-2-yl]-1- benzyl-1,2,3-triazoles
A.B. Theocharis, and N.E. Alexandrou Synthesis and spectral data of 4,5-bis[5-aryl-1,3,4-oxadiazol-2-yl]-1-benzyl-1,2,3-triazoles J. Heterocyclic Chem. 27 1990 1685 1688
The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach
DOI 10.1158/1535-7163.MCT-04-0333
K.A. Jessen, N.M. English, J. Yu Wang, S. Maliartchouk, S.P. Archer, L. Qiu, R. Brand, J. Kuemmerle, H.Z. Zhang, and K. Gehlsen The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach Mol. Cancer Ther. 4 2005 761 771 (Pubitemid 40767120)
TIP47 confers resistance to taxol-induced cell death by preventing the nuclear translocation of AIF and Endonuclease G
E. Hocsak, B. Racz, A. Szabo, E. Pozsgai, A. Szigeti, E. Szigeti, F. Gallyas Jr., B. Sumegi, S. Javor, and S. Bellyei TIP47 confers resistance to taxol-induced cell death by preventing the nuclear translocation of AIF and Endonuclease G Eur. J. Cell Biol. 89 2010 853 861
TIP47 p.otects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death
E. Hocsak, B. Racz, A. Szabo, L. Mester, E. Rapolti, E. Pozsgai, S. Javor, S. Bellyei, F. Gallyas Jr., and B. Sumegi TIP47 p.otects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death FEBS Lett. 584 2010 2953 2960
11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
DOI 10.1016/j.bmcl.2006.04.080, PII S0960894X06005166
11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase Bioorg. Med. Chem. Lett. 16 2006 4102 4106 (Pubitemid 44425196)
A new one pot method for the conversion of aldehydes into nitriles using hydroxyamine and phthalic anhydride
E.C. Wang, and G.J. Lin A new one pot method for the conversion of aldehydes into nitriles using hydroxyamine and phthalic anhydride Tetrahedron Lett. 39 1998 4047 4050
Process development of the PDE IV inhibitor 3-(cyclopentyloxy)-N-(3,5- dichloropyrid-4-yl)-4-methoxybenzamide
D.C. Cook, R.H. Jones, H. Kabir, D.J. Lythgoe, I.M. McFarlane, C. Pemberton, A.A. Thatcher, D.M. Thompson, and J.B. Walton Process development of the PDE IV inhibitor 3-(cyclopentyloxy)-N-(3,5-dichloropyrid-4-yl)-4- methoxybenzamide Org. Process Res. Dev. 2 1998 157 168
