메뉴 건너뛰기




Volumn 33, Issue 15, 2013, Pages 6245-6256

A transgenic alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric Aβ, and frank neuronal loss

(19)  Cohen, Robert M a,f,i   Rezai Zadeh, Kavon a   Weitz, Tara M a   Rentsendorj, Altan a   Gate, David a   Spivak, Inna a   Bholat, Yasmin a   Vasilevko, Vitaly b   Glabe, Charles G b   Breunig, Joshua J a   Rakic, Pasko c   Davtyan, Hayk b,d   Agadjanyan, Michael G b,d   Kepe, Vladimir f   Barrio, Jorge R f   Bannykh, Serguei a,f   Szekely, Christine A a   Pechnick, Robert N a,e,h   Town, Terrence a,f,g  


Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; TAU PROTEIN;

EID: 84875975993     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3672-12.2013     Document Type: Article
Times cited : (352)

References (64)
  • 1
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
    • Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR (2001) Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 21:RC189.
    • (2001) J Neurosci , vol.21
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Flores-Torres, S.4    Satyamurthy, N.5    Petric, A.6    Cole, G.M.7    Small, G.W.8    Huang, S.C.9    Barrio, J.R.10
  • 2
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence: A neuro-physiological and behavioral study in the rat
    • Barnes CA (1979) Memory deficits associated with senescence: a neuro-physiological and behavioral study in the rat. J Comp Physiol Psychol 93:74-104.
    • (1979) J Comp Physiol Psychol , vol.93 , pp. 74-104
    • Barnes, C.A.1
  • 3
    • 0028025251 scopus 로고
    • LTP saturation and spatial learning disruption: Effects of task variables and saturation levels
    • Barnes CA, Jung MW, McNaughton BL, Korol DL, Andreasson K, Worley PF (1994) LTP saturation and spatial learning disruption: effects of task variables and saturation levels. J Neurosci 14:5793-5806.
    • (1994) J Neurosci , vol.14 , pp. 5793-5806
    • Barnes, C.A.1    Jung, M.W.2    McNaughton, B.L.3    Korol, D.L.4    Andreasson, K.5    Worley, P.F.6
  • 4
    • 0033739282 scopus 로고    scopus 로고
    • Apoptosis and Alzheimer's disease
    • Behl C (2000) Apoptosis and Alzheimer's disease. J Neural Transm 107: 1325-1344.
    • (2000) J Neural Transm , vol.107 , pp. 1325-1344
    • Behl, C.1
  • 5
    • 0025247775 scopus 로고
    • Alzheimer's disease: Striatal amyloid deposits and neurofibrillary changes
    • Braak H, Braak E (1990) Alzheimer's disease: striatal amyloid deposits and neurofibrillary changes. J Neuropathol Exp Neurol 49:215-224.
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 215-224
    • Braak, H.1    Braak, E.2
  • 6
    • 0024431974 scopus 로고
    • Alzheimer's disease: Amyloid plaques in the cerebellum
    • Braak H, Braak E, Bohl J, Lang W (1989) Alzheimer's disease: amyloid plaques in the cerebellum. J Neurol Sci 93:277-287.
    • (1989) J Neurol Sci , vol.93 , pp. 277-287
    • Braak, H.1    Braak, E.2    Bohl, J.3    Lang, W.4
  • 9
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neuro-degeneration and Alzheimer's disease
    • Cotman CW, Anderson AJ (1995) A potential role for apoptosis in neuro-degeneration and Alzheimer's disease. Mol Neurobiol 10:19-45.
    • (1995) Mol Neurobiol , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 12
    • 0025210629 scopus 로고
    • Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease
    • Dickson DW, Wertkin A, Mattiace LA, Fier E, Kress Y, Davies P, Yen SH (1990) Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol 79: 486-493.
    • (1990) Acta Neuropathol , vol.79 , pp. 486-493
    • Dickson, D.W.1    Wertkin, A.2    Mattiace, L.A.3    Fier, E.4    Kress, Y.5    Davies, P.6    Yen, S.H.7
  • 14
    • 0029973286 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, Part XV
    • Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, Heyman A (1996) Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 46: 1592-1596.
    • (1996) Neurology , vol.46 , pp. 1592-1596
    • Ellis, R.J.1    Olichney, J.M.2    Thal, L.J.3    Mirra, S.S.4    Morris, J.C.5    Beekly, D.6    Heyman, A.7
  • 17
    • 57249084239 scopus 로고    scopus 로고
    • Neuronal cell death in neurodegenerative diseases: Recurring themes around protein handling
    • Gorman AM (2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. J Cell Mol Med 12:2263-2280.
    • (2008) J Cell Mol Med , vol.12 , pp. 2263-2280
    • Gorman, A.M.1
  • 18
    • 0025292866 scopus 로고
    • A preparation of Alzheimer paired helical filaments that displays distinct tau proteinsby polyacrylamide gel electro-phoresis
    • Greenberg SG, Davies P (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteinsby polyacrylamide gel electro-phoresis. Proc Natl Acad Sci U S A 87:5827-5831.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 5827-5831
    • Greenberg, S.G.1    Davies, P.2
  • 19
    • 59449092116 scopus 로고    scopus 로고
    • Rat tau proteome consists of six tau isoforms: Implication for animal models of human tauopathies
    • Hanes J, Zilka N, Bartkova M, Caletkova M, Dobrota D, Novak M (2009) Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies. J Neurochem 108:1167-1176.
    • (2009) J Neurochem , vol.108 , pp. 1167-1176
    • Hanes, J.1    Zilka, N.2    Bartkova, M.3    Caletkova, M.4    Dobrota, D.5    Novak, M.6
  • 20
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12:383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 26
    • 0024447098 scopus 로고
    • Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease
    • Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 135:309- 319.
    • (1989) Am J Pathol 135:309- , pp. 319
    • Joachim, C.L.1    Morris, J.H.2    Selkoe, D.J.3
  • 28
    • 33749507375 scopus 로고    scopus 로고
    • Conformation-dependent anti-amyloid oli-gomer antibodies
    • Kayed R, Glabe CG (2006) Conformation-dependent anti-amyloid oli-gomer antibodies. Methods Enzymol 413:326-344.
    • (2006) Methods Enzymol , vol.413 , pp. 326-344
    • Kayed, R.1    Glabe, C.G.2
  • 30
    • 0024819147 scopus 로고
    • Comparison of seven staining methods for senile plaques and neurofibrillary tangles in a prospective series of 15 elderly patients
    • Lamy C, Duyckaerts C, Delaere P, Payan C, Fermanian J, Poulain V, Hauw JJ (1989) Comparison of seven staining methods for senile plaques and neurofibrillary tangles in a prospective series of 15 elderly patients. Neu-ropathol Appl Neurobiol 15:563-578.
    • (1989) Neu-ropathol Appl Neurobiol , vol.15 , pp. 563-578
    • Lamy, C.1    Duyckaerts, C.2    Delaere, P.3    Payan, C.4    Fermanian, J.5    Poulain, V.6    Hauw, J.J.7
  • 38
    • 33749521100 scopus 로고    scopus 로고
    • Intraneu-ronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R (2006) Intraneu-ronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 26:10129-10140.
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 40
    • 33750582958 scopus 로고    scopus 로고
    • Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons
    • Padmanabhan J, Levy M, Dickson DW, Potter H (2006) Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain 129:3020-3034.
    • (2006) Brain , vol.129 , pp. 3020-3034
    • Padmanabhan, J.1    Levy, M.2    Dickson, D.W.3    Potter, H.4
  • 42
    • 77951226607 scopus 로고    scopus 로고
    • Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss
    • Rebeck GW, Hoe HS, Moussa CE (2010) Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss. J Biol Chem 285:7440-7446.
    • (2010) J Biol Chem , vol.285 , pp. 7440-7446
    • Rebeck, G.W.1    Hoe, H.S.2    Moussa, C.E.3
  • 43
    • 0027279693 scopus 로고
    • Comparison of silver stainings and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections
    • Rosenwald A, Reusche E, Ogomori K, Teichert HM (1993) Comparison of silver stainings and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections. Acta Neu-ropathol 86:182-186.
    • (1993) Acta Neu-ropathol , vol.86 , pp. 182-186
    • Rosenwald, A.1    Reusche, E.2    Ogomori, K.3    Teichert, H.M.4
  • 44
    • 0024428072 scopus 로고
    • A4 protein in Alzheimer's disease: Primary and secondary cellular events in extracellular amyloid deposition
    • Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL (1989) A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 48:674-691.
    • (1989) J Neuropathol Exp Neurol , vol.48 , pp. 674-691
    • Rozemuller, J.M.1    Eikelenboom, P.2    Stam, F.C.3    Beyreuther, K.4    Masters, C.L.5
  • 45
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 48
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    • Stadelmann C, Brück W, Bancher C, Jellinger K, Lassmann H (1998) Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol 57:456-464.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 456-464
    • Stadelmann, C.1    Brück, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 51
    • 0035917831 scopus 로고    scopus 로고
    • Activated caspase-3 expression in Alzheimer's and aged control brain: Correlation with Alzheimer pathology
    • Su JH, Zhao M, Anderson AJ, Srinivasan A, Cotman CW (2001) Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res 898:350-357.
    • (2001) Brain Res , vol.898 , pp. 350-357
    • Su, J.H.1    Zhao, M.2    Anderson, A.J.3    Srinivasan, A.4    Cotman, C.W.5
  • 55
    • 0034609516 scopus 로고    scopus 로고
    • The oli-gomerization of amyloid beta-protein begins intracellularly in cells derived from human brain
    • Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ (2000) The oli-gomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 39:10831-10839.
    • (2000) Biochemistry , vol.39 , pp. 10831-10839
    • Walsh, D.M.1    Tseng, B.P.2    Rydel, R.E.3    Podlisny, M.B.4    Selkoe, D.J.5
  • 56
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation invivo
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002a) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation invivo. Nature 416:535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 58
    • 0344882570 scopus 로고    scopus 로고
    • Different contributions of the hippocampus and perirhinal cortex to recognition memory
    • Wan H, Aggleton JP, Brown MW (1999) Different contributions of the hippocampus and perirhinal cortex to recognition memory. J Neurosci 19: 1142-1148.
    • (1999) J Neurosci , vol.19 , pp. 1142-1148
    • Wan, H.1    Aggleton, J.P.2    Brown, M.W.3
  • 59
    • 39549115445 scopus 로고    scopus 로고
    • Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2
    • Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Ghark-holonarehe N, Vitek MP, Colton CA (2008) Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28:1537-1545.
    • (2008) J Neurosci , vol.28 , pp. 1537-1545
    • Wilcock, D.M.1    Lewis, M.R.2    van Nostrand, W.E.3    Davis, J.4    Previti, M.L.5    Ghark-Holonarehe, N.6    Vitek, M.P.7    Colton, C.A.8
  • 61
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L (2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med 7:612-618.
    • (2001) Nat Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6    Masliah, E.7    Mucke, L.8
  • 64
    • 33748466130 scopus 로고    scopus 로고
    • Apoptosis in Alzheimer disease: A mathematical improbability
    • Zhu X, Raina AK, Perry G, Smith MA (2006) Apoptosis in Alzheimer disease: a mathematical improbability. Curr Alzheimer Res 3:393-396.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 393-396
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.