β-Amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7440-7446

  Rebeck, G William ^a   Hoe, Hyang Sook ^a   Moussa, Charbel E H ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANIMAL MODEL; EXTRACELLULAR; HYPERPHOSPHORYLATION; NEURODEGENERATIVE; NEUROFIBRILLARY TANGLES; NEURONAL CELL; NEURONAL LOSS; PATHOLOGICAL CHANGES; PRIMARY MOTOR CORTEX; TARGETED DELIVERY;

ANIMALS; BIOINFORMATICS; CELL DEATH; DISEASES; ENZYME ACTIVITY; GLYCOPROTEINS; PHOSPHORYLATION; PROTEINS;

GENE TRANSFER;

AMYLOID BETA PROTEIN[1-42]; TAU PROTEIN; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PARKIN; PEPTIDE FRAGMENT; PROTEIN KINASE B; UBIQUITIN PROTEIN LIGASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENCEPHALITIS; EXTRACELLULAR MATRIX; GENE TRANSFER; GLIOSIS; INTRACELLULAR SPACE; LENTIVIRINAE; MOTOR CORTEX; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BRAIN CORTEX; CELL DEATH; CELL SURVIVAL; CYTOLOGY; DISEASE MODEL; GENETICS; HUMAN; INFLAMMATION; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; CELL DEATH; CELL SURVIVAL; CEREBRAL CORTEX; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INFLAMMATION; MICE; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TAU PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 77951226607     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.083915     Document Type: Article

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