-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297(5580):353-356.
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0038708285
-
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
-
Giannakopoulos P, Herrmann FR, Bussiere T, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology. 2003;60(9):1495-1500.
-
(2003)
Neurology
, vol.60
, Issue.9
, pp. 1495-1500
-
-
Giannakopoulos, P.1
Herrmann, F.R.2
Bussiere, T.3
-
3
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 1992;42(3, pt 1):631-639.
-
(1992)
Neurology
, vol.42
, Issue.3 and PART 1
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
4
-
-
14444285507
-
Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype
-
Berg L, McKeel DW Jr, Miller JP, et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol. 1998;55(3):326-335.
-
(1998)
Arch Neurol
, vol.55
, Issue.3
, pp. 326-335
-
-
Berg, L.1
McKeel Jr, D.W.2
Miller, J.P.3
-
5
-
-
0029671451
-
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
-
Kuo YM, Emmerling MR, Vigo-Pelfrey C, et al. Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem. 1996;271(8):4077-4081.
-
(1996)
J Biol Chem
, vol.271
, Issue.8
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
-
6
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y, Chang L, Viola KL, et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A. 2003;100(18):10417- 10422.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.18
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
-
7
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006;440(7082):352-357.
-
(2006)
Nature
, vol.440
, Issue.7082
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
-
8
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Näslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA. 2000;283(12):1571-1577.
-
(2000)
JAMA
, vol.283
, Issue.12
, pp. 1571-1577
-
-
Näslund, J.1
Haroutunian, V.2
Mohs, R.3
-
9
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean CA, Cherny RA, Fraser FW, et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol. 1999;46(6):860-866.
-
(1999)
Ann Neurol
, vol.46
, Issue.6
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
-
10
-
-
0027361386
-
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides
-
Wertkin AM, Turner RS, Pleasure SJ, et al. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci U S A. 1993;90(20):9513-9517.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, Issue.20
, pp. 9513-9517
-
-
Wertkin, A.M.1
Turner, R.S.2
Pleasure, S.J.3
-
11
-
-
0031781642
-
Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
-
Skovronsky DM, Doms RW, Lee VM. Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. J Cell Biol. 1998;141(4):1031-1039.
-
(1998)
J Cell Biol
, vol.141
, Issue.4
, pp. 1031-1039
-
-
Skovronsky, D.M.1
Doms, R.W.2
Lee, V.M.3
-
12
-
-
33745920161
-
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
-
Bateman RJ, Munsell LY, Morris JC, et al. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med. 2006;12(7):856-861.
-
(2006)
Nat Med
, vol.12
, Issue.7
, pp. 856-861
-
-
Bateman, R.J.1
Munsell, L.Y.2
Morris, J.C.3
-
13
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T, Younkin LH, Saido TC, et al. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci. 2001;21(2):372-381.
-
(2001)
J Neurosci
, vol.21
, Issue.2
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
-
14
-
-
33947507128
-
Fluctuations of CSF amyloid-beta levels: Implications for a diagnostic and therapeutic biomarker
-
Bateman RJ, Wen G, Morris JC, Holtzman DM. Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker. Neurology. 2007;68(9):666-669.
-
(2007)
Neurology
, vol.68
, Issue.9
, pp. 666-669
-
-
Bateman, R.J.1
Wen, G.2
Morris, J.C.3
Holtzman, D.M.4
-
15
-
-
0027245621
-
-
Richards M, Folstein M, Albert M, et al. Multicenter study of predictors of disease course in Alzheimer disease (the predictors study), II: neurological, psychiatric, and demographic influences on baseline measures of disease severity. Alzheimer Dis Assoc Disord. 1993;7(1):22-32.
-
Richards M, Folstein M, Albert M, et al. Multicenter study of predictors of disease course in Alzheimer disease (the "predictors study"), II: neurological, psychiatric, and demographic influences on baseline measures of disease severity. Alzheimer Dis Assoc Disord. 1993;7(1):22-32.
-
-
-
-
16
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
Fukumoto H, Cheung BS, Hyman BT, Irizarry MC. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol. 2002;59(9):1381-1389.
-
(2002)
Arch Neurol
, vol.59
, Issue.9
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
17
-
-
0001543717
-
Modified Mini-Mental State Examination: Validity and reliability [abstract]
-
Stern YSM, Paulson J, Mayeux R. Modified Mini-Mental State Examination: validity and reliability [abstract]. Neurology. 1987;37(2)(suppl 1):179.
-
(1987)
Neurology
, vol.37
, Issue.2 SUPPL. 1
, pp. 179
-
-
Stern, Y.S.M.1
Paulson, J.2
Mayeux, R.3
-
18
-
-
0016823810
-
Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician
-
Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198.
-
(1975)
J Psychiatr Res
, vol.12
, Issue.3
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
21
-
-
0014313861
-
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
-
Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968;114(512):797-811.
-
(1968)
Br J Psychiatry
, vol.114
, Issue.512
, pp. 797-811
-
-
Blessed, G.1
Tomlinson, B.E.2
Roth, M.3
-
22
-
-
0022673130
-
Longitudinal data analysis for discrete and continuous outcomes
-
Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics. 1986;42(1):121-130.
-
(1986)
Biometrics
, vol.42
, Issue.1
, pp. 121-130
-
-
Zeger, S.L.1
Liang, K.Y.2
-
23
-
-
0029664434
-
Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease
-
Gearing M, Mori H, Mirra SS. Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann Neurol. 1996;39(3):395-399.
-
(1996)
Ann Neurol
, vol.39
, Issue.3
, pp. 395-399
-
-
Gearing, M.1
Mori, H.2
Mirra, S.S.3
-
24
-
-
0030615092
-
Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease
-
Ishii K, Tamaoka A, Mizusawa H, et al. Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease. Brain Res. 1997;748(1-2):250-252.
-
(1997)
Brain Res
, vol.748
, Issue.1-2
, pp. 250-252
-
-
Ishii, K.1
Tamaoka, A.2
Mizusawa, H.3
-
25
-
-
1842510004
-
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
-
Ingelsson M, Fukumoto H, Newell KL, et al. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 2004;62(6):925-931.
-
(2004)
Neurology
, vol.62
, Issue.6
, pp. 925-931
-
-
Ingelsson, M.1
Fukumoto, H.2
Newell, K.L.3
-
26
-
-
22544482926
-
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
-
McGowan E, Pickford F, Kim J, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005;47(2):191-199.
-
(2005)
Neuron
, vol.47
, Issue.2
, pp. 191-199
-
-
McGowan, E.1
Pickford, F.2
Kim, J.3
-
27
-
-
25144501662
-
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
-
Gouras GK, Almeida CG, Takahashi RH. Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging. 2005;26(9):1235-1244.
-
(2005)
Neurobiol Aging
, vol.26
, Issue.9
, pp. 1235-1244
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
28
-
-
0034745017
-
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome
-
Gyure KA, Durham R, Stewart WF, et al. Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med. 2001;125(4):489-492.
-
(2001)
Arch Pathol Lab Med
, vol.125
, Issue.4
, pp. 489-492
-
-
Gyure, K.A.1
Durham, R.2
Stewart, W.F.3
-
29
-
-
33749521100
-
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
-
Oakley H, Cole SL, Logan S, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006;26(40):10129-10140.
-
(2006)
J Neurosci
, vol.26
, Issue.40
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
-
30
-
-
4644319713
-
Abeta localization in abnormal endosomes: Association with earliest Abeta elevations in AD and Down syndrome
-
Cataldo AM, Petanceska S, Terio NB, et al. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging. 2004;25(10):1263-1272.
-
(2004)
Neurobiol Aging
, vol.25
, Issue.10
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
-
31
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
Billings LM, Oddo S, Green KN, et al. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005;45(5):675-688.
-
(2005)
Neuron
, vol.45
, Issue.5
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
-
32
-
-
0034609516
-
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain
-
Walsh DM, Tseng BP, Rydel RE, et al. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 2000;39(35):10831-10839.
-
(2000)
Biochemistry
, vol.39
, Issue.35
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
-
33
-
-
1842732209
-
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi RH, Almeida CG, Kearney PF, et al. Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci. 2004;24(14):3592-3599.
-
(2004)
J Neurosci
, vol.24
, Issue.14
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
-
34
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi RH, Milner TA, Li F, et al. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol. 2002;161(5):1869-1879.
-
(2002)
Am J Pathol
, vol.161
, Issue.5
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
-
35
-
-
33646461282
-
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
Almeida CG, Takahashi RH, Gouras GK. Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci. 2006;26(16):4277-4288.
-
(2006)
J Neurosci
, vol.26
, Issue.16
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
36
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E, Meng Y, Lee JH, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet. 2007;39(2):168-177.
-
(2007)
Nat Genet
, vol.39
, Issue.2
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
-
37
-
-
33749042749
-
Sorting through the cell biology of Alzheimer's disease: Intracellular pathways to pathogenesis
-
Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron. 2006;52(1):15-31.
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 15-31
-
-
Small, S.A.1
Gandy, S.2
-
38
-
-
33846021307
-
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
-
Zerbinatti CV, Wahrle SE, Kim H, et al. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. J Biol Chem. 2006;281(47):36180- 36186.
-
(2006)
J Biol Chem
, vol.281
, Issue.47
, pp. 36180-36186
-
-
Zerbinatti, C.V.1
Wahrle, S.E.2
Kim, H.3
-
39
-
-
21844448609
-
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay
-
Stenh C, Englund H, Lord A, et al. Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay. Ann Neurol. 2005;58(1):147-150.
-
(2005)
Ann Neurol
, vol.58
, Issue.1
, pp. 147-150
-
-
Stenh, C.1
Englund, H.2
Lord, A.3
|