Saturated Fat and Cardiovascular Disease: A Review of Current Evidence

Current Cardiovascular Risk Reports

Volumn 7, Issue 2, 2013, Pages 154-162

  O'Keeffe, Majella ^a,b   St Onge, Marie Pierre ^b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^c Columbia University ^*  (United States)

Author keywords

Cardiovascular disease; Dairy; Dietary guidelines; Meat; Saturated fat

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; TRIACYLGLYCEROL;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DAIRY PRODUCT; DIET; FAT INTAKE; HUMAN; RED MEAT; REVIEW; VEGETABLE;

EID: 84875452932     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-013-0295-z     Document Type: Review

References (88)

1. Deaton C et al. The global burden of cardiovascular disease. Eur J Cardiovasc Nurs. 2011; 10(2): 5-13.
2. Celermajer DS et al. Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J Am Coll Cardiol. 2012; 60(14): 1207-16.
3. Ergin A et al. Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med. 2004; 117(4): 219-27.
4. Roger VL et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation. 2012; 125(1): e2-e220.
5. Xu J., et al. Deaths: final data for 2007, 2010, National Center for Health Statistics: Hyattsville, MD. p. 1-135.
6. Thom T et al. Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006; 113(6): e85-151.
7. Mensah GA et al. State of disparities in cardiovascular health in the United States. Circulation. 2005; 111(10): 1233-41.
8. CDC, Racial/ethnic and socioeconomic disparities in multiple risk factors for heart disease and stroke-United States, 2003. in Morbidity and Mortality Weekly Report 2003. 113-7.
9. Long Y et al. Analysis of the prevalence of cardiovascular disease and associated risk factors for European-American and African-American Populations in the State of Pennsylvania 2005-2009. Am J Cardiol. 2012. doi: 10. 1016/j. amjcard. 2012. 08. 045.
10. Hertz RP et al. Racial disparities in hypertension prevalence, awareness, and management. Arch Intern Med. 2005; 165(18): 2098-104.
11. Keys A et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol. 1986; 124(6): 903-15.
12. Keys A, Blackburn H, Menotti A. Coronary heart disease in seven countries. Circulation. 1970; 41(1): 1-211.
13. Keys A. Coronary heart disease in seven countries. Circulation. 1970; 41(S1): 1-211.
14. Keys A et al. The seven countries study: 2, 289 deaths in 15 years. Prev Med. 1984; 13(2): 141-54.
15. Anderson KM, Castelli WP, Levy D. Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA. 1987; 257(16): 2176-80.
16. Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982; 248(12): 1465-77.
17. Kushi LH et al. Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. N Engl J Med. 1985; 312(13): 811-8.
18. Astrup A et al. The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr. 2011; 93(4): 684-8.
19. Volk MG. An examination of the evidence supporting the association of dietary cholesterol and saturated fats with serum cholesterol and development of coronary heart disease. Altern Med Rev. 2007; 12(3): 228-45.
20. Ravnskov U. A hypothesis out-of-date. the diet-heart idea. J Clin Epidemiol. 2002; 55(11): 1057-63.
21. Hoenselaar R. Saturated fat and cardiovascular disease: the discrepancy between the scientific literature and dietary advice. Nutrition. 2012; 28(2): 118-23.
22. USDA/UDHHS, Report of the Dietary Guidelines Advisory Committee on the dietary guidelines for Americans, 2010, U. S. D. o. Agriculture and U. S. D. o. H. a. H. Services, Editors. 2010.
23. American Heart Association Nutrition Committee, Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, van Horn L, Winston M, Wylie-Rosett J. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114(1): 82-96.
24. Medicine, I. O., Dietary fats: total fat and fatty acids. In: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids (macronutrients), 2005.
25. EFSA, Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. ESFA J. 2010; 8(3): 1461.
26. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010; 7(3): e1000252.
27. Beulens JW et al. High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study. J Am Coll Cardiol. 2007; 50(1): 14-21.
28. Levitan EB et al. Dietary glycemic index, dietary glycemic load, and cardiovascular disease in middle-aged and older Swedish men. Am J Clin Nutr. 2007; 85(6): 1521-6.
29. Sacks FM, Katan M. Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med. 2002; 113(Suppl 9B): 13S-24S.
30. van Dam RM et al. Dietary glycemic index in relation to metabolic risk factors and incidence of coronary heart disease: the Zutphen Elderly Study. Eur J Clin Nutr. 2000; 54(9): 726-31.
31. Bolland MJ et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010; 341: c3691.
32. Soedamah-Muthu SS et al. Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011; 93(1): 158-71.
33. van Aerde, M. A., et al., Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn Study. Eur J Nutr. 2012;.
34. Bernstein AM et al. Major dietary protein sources and risk of coronary heart disease in women. Circulation. 2010; 122(9): 876-83.
35. Goldbohm RA et al. Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr. 2011; 93(3): 615-27.
36. Sonestedt E et al. Dairy products and its association with incidence of cardiovascular disease: the Malmo diet and cancer cohort. Eur J Epidemiol. 2011; 26(8): 609-18.
37. Elwood PC et al. The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids. 2010; 45(10): 925-39.
38. German JB et al. A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur J Nutr. 2009; 48(4): 191-203.
39. Mozaffarian D, Aro A, Willett WC. Health effects of trans-fatty acids: experimental and observational evidence. Eur J Clin Nutr. 2009; 63 Suppl 2: S5-21.
40. Malpuech-Brugere C et al. Differential impact of milk fatty acid profiles on cardiovascular risk biomarkers in healthy men and women. Eur J Clin Nutr. 2010; 64(7): 752-9.
41. Intorre F et al. Differential effect of cheese fatty acid composition on blood lipid profile and redox status in normolipidemic volunteers: a pilot study. Int J Food Sci Nutr. 2011; 62(6): 660-9.
42. Ivey KL et al. Association between yogurt, milk, and cheese consumption and common carotid artery intima-media thickness and cardiovascular disease risk factors in elderly women. Am J Clin Nutr. 2011; 94(1): 234-9.
43. Hodis HN et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998; 128(4): 262-9.
44. Hjerpsted J, Leedo E, Tholstrup T. Cheese intake in large amounts lowers LDL-cholesterol concentrations compared with butter intake of equal fat content. Am J Clin Nutr. 2011; 94(6): 1479-84.
45. Everett DW, Auty MAE. Cheese structure and current methods of analysis. Int Dairy J. 2008; 18: 759-73.
46. http://riskfactor. cancer. gov/diet/foodsources/sat_fat/. Sources of Saturated Fat, Stearic Acid, & Cholesterol Raising Fat among the US Population, 2005-06. 2010 [cited 2012 November 28].
47. Sinha R et al. Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med. 2009; 169(6): 562-71.
48. http://www. hsph. harvard. edu/nutritionsource/what-should-you-eat/dietary-guidelines-2010/index. html. 2012 [cited 2012 October 21].
49. Linseisen J et al. Meat consumption in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts: results from 24-hour dietary recalls. Public Health Nutr. 2002; 5(6B): 1243-58.
50. Maki KC et al. A meta-analysis of randomized controlled trials that compare the lipid effects of beef versus poultry and/or fish consumption. J Clin Lipidol. 2012; 6(4): 352-61.
51. Mensink RP. Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. Am J Clin Nutr. 1993; 57(5 Suppl): 711S-4S.
52. Kris-Etherton PM, Yu S. Individual fatty acid effects on plasma lipids and lipoproteins: human studies. Am J Clin Nutr. 1997; 65(5 Suppl): 1628S-44S.
53. Hunter JE, Zhang J, Kris-Etherton PM. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review. Am J Clin Nutr. 2010; 91(1): 46-63.
54. Bonanome A, Grundy SM. Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med. 1988; 318(19): 1244-8.
55. Kaluza J, Wolk A, Larsson SC. Red meat consumption and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012; 43(10): 2556-60.
56. Kimura Y et al. Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci. 2007; 98(4): 590-7.
57. Fraser GE. Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. Am J Clin Nutr. 1999; 70(3 Suppl): 532S-8S.
58. Micha R, Wallace SK, Mozaffarian D. Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis. Circulation. 2010; 121(21): 2271-83.
59. Larsson SC, Virtamo J, Wolk A. Red meat consumption and risk of stroke in Swedish men. Am J Clin Nutr. 2011; 94(2): 417-21.
60. Wang L et al. Meat intake and the risk of hypertension in middle-aged and older women. J Hypertens. 2008; 26(2): 215-22.
61. Ashaye A, Gaziano J, Djousse L. Red meat consumption and risk of heart failure in male physicians. Nutr Metab Cardiovasc Dis. 2011; 21(12): 941-6.
62. Roussell MA et al. Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr. 2012; 95(1): 9-16.
63. St-Onge MP et al. Baseline serum C-reactive protein is associated with lipid responses to low-fat and high-polyunsaturated fat diets. J Nutr. 2009; 139(4): 680-3.
64. Hilpert KF, Kris-Etherton PM, West SG. Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults. J Nutr. 2005; 135(5): 1075-9.
65. Desroches S et al. Baseline plasma C-reactive protein concentrations influence lipid and lipoprotein responses to low-fat and high monounsaturated fatty acid diets in healthy men. J Nutr. 2006; 136(4): 1005-11.
66. Arsenault BJ et al. HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Atherosclerosis. 2009; 206(1): 276-81.
67. El Harchaoui K et al. High-density lipoprotein particle size and concentration and coronary risk. Ann Intern Med. 2009; 150(2): 84-93.
68. Mateo-Gallego, R., et al., Effect of lean red meat from lamb v. lean white meat from chicken on the serum lipid profile: a randomised, cross-over study in women. Br J Nutr. 2012; 107(10): 1403-7.
69. Willett WC. The Mediterranean diet: science and practice. Public Health Nutr. 2006; 9(1A): 105-10.
70. St-Onge MP et al. Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res. 2003; 11(3): 395-402.
71. Han JR et al. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism. 2007; 56(7): 985-91.
72. St-Onge MP, Bosarge A. Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil. Am J Clin Nutr. 2008; 87(3): 621-6.
73. Denke MA, Grundy SM. Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. Am J Clin Nutr. 1992; 56(5): 895-8.
74. Schwab US et al. Lauric and palmitic acid-enriched diets have minimal impact on serum lipid and lipoprotein concentrations and glucose metabolism in healthy young women. J Nutr. 1995; 125(3): 466-73.
75. Voon PT et al. Diets high in palmitic acid (16: 0), lauric and myristic acids (12: 0 + 14: 0), or oleic acid (18: 1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Clin Nutr. 2011; 94(6): 1451-7.
76. Mensink RP et al. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003; 77(5): 1146-55.
77. Oguntibeju OO, Esterhuyse AJ, Truter EJ. Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life. Br J Biomed Sci. 2009; 66(4): 216-22.
78. Edem DO. Palm oil: biochemical, physiological, nutritional, hematological, and toxicological aspects: a review. Plant Foods Hum Nutr. 2002; 57(3-4): 319-41.
79. Chiu MC, De C, Coutinho M, Aparecida L, Goncalves G. Carotenoid concentration of red palm oil using membrane technology. Desalination. 2009; 246: 410-3.
80. Karupaiah T et al. The chain length of dietary saturated fatty acids affects human postprandial lipemia. J Am Coll Nutr. 2011; 30(6): 511-21.
81. Ooi TC et al. Postprandial remnant-like lipoproteins in hypertriglyceridemia. J Clin Endocrinol Metab. 2001; 86(7): 3134-42.
82. Havel RJ. Remnant lipoproteins as therapeutic targets. Curr Opin Lipidol. 2000; 11(6): 615-20.
83. Tholstrup T, Teng KT, Raff M. Dietary cocoa butter or refined olive oil does not alter postprandial hsCRP and IL-6 concentrations in healthy women. Lipids. 2011; 46(4): 365-70.
84. Tholstrup T, Hjerpsted J, Raff M. Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals. Am J Clin Nutr. 2011; 94(6): 1426-32.
85. DebMandal M, Mandal S. Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention. Asian Pac. J Trop Med. 2011; 4(3): 241-7.
86. Stamler J. Diet-heart: a problematic revisit. Am J Clin Nutr. 2010; 91(3): 497-9.
87. Siri-Tarino PW et al. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010; 91(3): 535-46.
88. USDA. http://ndb. nal. usda. gov. 2011 [cited 2012 December 1].