메뉴 건너뛰기




Volumn 138, Issue 2, 2013, Pages 197-210

Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention

Author keywords

Adipocyte; Cancer metabolism; Obesity; Stromal compartment

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ESTROGEN; INTERLEUKIN 6; LEPTIN; METFORMIN; PIOGLITAZONE; PROTEIN LYSINE 6 OXIDASE;

EID: 84875227258     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.01.008     Document Type: Review
Times cited : (100)

References (185)
  • 3
    • 28244496184 scopus 로고    scopus 로고
    • Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front
    • K.L. Andarawewa, E.R. Motrescu, M.P. Chenard, A. Gansmuller, I. Stoll, and C. Tomasetto Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front Cancer Res 65 2005 10862 10871
    • (2005) Cancer Res , vol.65 , pp. 10862-10871
    • Andarawewa, K.L.1    Motrescu, E.R.2    Chenard, M.P.3    Gansmuller, A.4    Stoll, I.5    Tomasetto, C.6
  • 4
    • 84155165679 scopus 로고    scopus 로고
    • Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors
    • M.L. Batista Jr., S.B. Peres, M.E. McDonald, P.S. Alcantara, M. Olivan, and J.P. Otoch Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors Cytokine 57 2012 9 16
    • (2012) Cytokine , vol.57 , pp. 9-16
    • Batista, Jr.M.L.1    Peres, S.B.2    McDonald, M.E.3    Alcantara, P.S.4    Olivan, M.5    Otoch, J.P.6
  • 5
    • 77955458963 scopus 로고    scopus 로고
    • The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
    • I. Ben Sahra, J.F. Tanti, and F. Bost The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells Autophagy 6 2010
    • (2010) Autophagy , vol.6
    • Ben Sahra, I.1    Tanti, J.F.2    Bost, F.3
  • 6
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 2001 947 953
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 7
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • G. Bonuccelli, A. Tsirigos, D. Whitaker-Menezes, S. Pavlides, R.G. Pestell, and B. Chiavarina Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism Cell Cycle 9 2010 3506 3514
    • (2010) Cell Cycle , vol.9 , pp. 3506-3514
    • Bonuccelli, G.1    Tsirigos, A.2    Whitaker-Menezes, D.3    Pavlides, S.4    Pestell, R.G.5    Chiavarina, B.6
  • 8
    • 4243150843 scopus 로고    scopus 로고
    • The role of TNF-alpha in insulin resistance
    • S.E. Borst The role of TNF-alpha in insulin resistance Endocrine 23 2004 177 182
    • (2004) Endocrine , vol.23 , pp. 177-182
    • Borst, S.E.1
  • 10
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • D.M. Brizel, S.P. Scully, J.M. Harrelson, L.J. Layfield, J.M. Bean, and L.R. Prosnitz Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res 56 1996 941 943
    • (1996) Cancer Res , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3    Layfield, L.J.4    Bean, J.M.5    Prosnitz, L.R.6
  • 11
    • 0042031680 scopus 로고    scopus 로고
    • Tumor microenvironment and the response to anticancer therapy
    • J.M. Brown Tumor microenvironment and the response to anticancer therapy Cancer Biol Ther 1 2002 453 458
    • (2002) Cancer Biol Ther , vol.1 , pp. 453-458
    • Brown, J.M.1
  • 14
    • 23944493604 scopus 로고    scopus 로고
    • Regulation of aromatase expression in estrogen-responsive breast and uterine disease: From bench to treatment
    • S.E. Bulun, Z. Lin, G. Imir, S. Amin, M. Demura, and B. Yilmaz Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment Pharmacol Rev 57 2005 359 383
    • (2005) Pharmacol Rev , vol.57 , pp. 359-383
    • Bulun, S.E.1    Lin, Z.2    Imir, G.3    Amin, S.4    Demura, M.5    Yilmaz, B.6
  • 16
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • E.E. Calle, and R. Kaaks Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nat Rev Cancer 4 2004 579 591
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 17
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • E.E. Calle, C. Rodriguez, K. Walker-Thurmond, and M.J. Thun Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med 348 2003 1625 1638
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 18
    • 33748314535 scopus 로고    scopus 로고
    • Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    • R. Cancello, J. Tordjman, C. Poitou, G. Guilhem, J.L. Bouillot, and D. Hugol Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity Diabetes 55 2006 1554 1561
    • (2006) Diabetes , vol.55 , pp. 1554-1561
    • Cancello, R.1    Tordjman, J.2    Poitou, C.3    Guilhem, G.4    Bouillot, J.L.5    Hugol, D.6
  • 19
    • 75849165542 scopus 로고    scopus 로고
    • Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
    • Y. Cao Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases Nat Rev Drug Discov 9 2010 107 115
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 107-115
    • Cao, Y.1
  • 20
    • 57349175662 scopus 로고    scopus 로고
    • Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells
    • J Int Cancer
    • C. Carino, A.B. Olawaiye, S. Cherfils, T. Serikawa, M.P. Lynch, and B.R. Rueda Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells Int J Cancer J Int Cancer 123 2008 2782 2790
    • (2008) Int J Cancer , vol.123 , pp. 2782-2790
    • Carino, C.1    Olawaiye, A.B.2    Cherfils, S.3    Serikawa, T.4    Lynch, M.P.5    Rueda, B.R.6
  • 21
    • 84860375795 scopus 로고    scopus 로고
    • Thiazolidinediones and PPARgamma agonists: Time for a reassessment
    • B. Cariou, B. Charbonnel, and B. Staels Thiazolidinediones and PPARgamma agonists: time for a reassessment Trends Endocrinol Metab 23 2012 205 215
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 205-215
    • Cariou, B.1    Charbonnel, B.2    Staels, B.3
  • 22
    • 38349080768 scopus 로고    scopus 로고
    • Mechanism of leptin expression in breast cancer cells: Role of hypoxia-inducible factor-1alpha
    • S. Cascio, V. Bartella, A. Auriemma, G.J. Johannes, A. Russo, and A. Giordano Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha Oncogene 27 2008 540 547
    • (2008) Oncogene , vol.27 , pp. 540-547
    • Cascio, S.1    Bartella, V.2    Auriemma, A.3    Johannes, G.J.4    Russo, A.5    Giordano, A.6
  • 23
    • 11244302456 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
    • T. Christiansen, B. Richelsen, and J.M. Bruun Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects Int J Obes 29 2005 146 150
    • (2005) Int J Obes , vol.29 , pp. 146-150
    • Christiansen, T.1    Richelsen, B.2    Bruun, J.M.3
  • 24
    • 33646139156 scopus 로고    scopus 로고
    • A pericellular collagenase directs the 3-dimensional development of white adipose tissue
    • T.H. Chun, K.B. Hotary, F. Sabeh, A.R. Saltiel, E.D. Allen, and S.J. Weiss A pericellular collagenase directs the 3-dimensional development of white adipose tissue Cell 125 2006 577 591
    • (2006) Cell , vol.125 , pp. 577-591
    • Chun, T.H.1    Hotary, K.B.2    Sabeh, F.3    Saltiel, A.R.4    Allen, E.D.5    Weiss, S.J.6
  • 25
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the adipose organ
    • S. Cinti Transdifferentiation properties of adipocytes in the adipose organ Am J Physiol Endocrinol Metab 297 2009 E977 E986
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Cinti, S.1
  • 27
    • 84857640591 scopus 로고    scopus 로고
    • Cancer associated fibroblasts: The dark side of the coin
    • P. Cirri, and P. Chiarugi Cancer associated fibroblasts: the dark side of the coin Am J Cancer Res 1 2011 482 497
    • (2011) Am J Cancer Res , vol.1 , pp. 482-497
    • Cirri, P.1    Chiarugi, P.2
  • 28
    • 0742287956 scopus 로고    scopus 로고
    • Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    • M.P. Cleary, S.C. Juneja, F.C. Phillips, X. Hu, J.P. Grande, and N.J. Maihle Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors Exp Biol Med 229 2004 182 193
    • (2004) Exp Biol Med , vol.229 , pp. 182-193
    • Cleary, M.P.1    Juneja, S.C.2    Phillips, F.C.3    Hu, X.4    Grande, J.P.5    Maihle, N.J.6
  • 30
    • 0034721666 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • L.M. Coussens, C.L. Tinkle, D. Hanahan, and Z. Werb MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis Cell 103 2000 481 490
    • (2000) Cell , vol.103 , pp. 481-490
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 31
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 32
    • 67349139615 scopus 로고    scopus 로고
    • Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: A case-control study
    • M. Dalamaga, I. Migdalis, J.L. Fargnoli, E. Papadavid, E. Bloom, and N. Mitsiades Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study Cancer Causes Control 20 2009 625 633
    • (2009) Cancer Causes Control , vol.20 , pp. 625-633
    • Dalamaga, M.1    Migdalis, I.2    Fargnoli, J.L.3    Papadavid, E.4    Bloom, E.5    Mitsiades, N.6
  • 33
    • 79960091939 scopus 로고    scopus 로고
    • Adipose triglyceride lipase contributes to cancer-associated cachexia
    • S.K. Das, S. Eder, S. Schauer, C. Diwoky, H. Temmel, and B. Guertl Adipose triglyceride lipase contributes to cancer-associated cachexia Science 333 2011 233 238
    • (2011) Science , vol.333 , pp. 233-238
    • Das, S.K.1    Eder, S.2    Schauer, S.3    Diwoky, C.4    Temmel, H.5    Guertl, B.6
  • 34
    • 31044451078 scopus 로고    scopus 로고
    • Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    • C. de Luca, T.J. Kowalski, Y. Zhang, J.K. Elmquist, C. Lee, and M.W. Kilimann Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes J Clin Invest 115 2005 3484 3493
    • (2005) J Clin Invest , vol.115 , pp. 3484-3493
    • De Luca, C.1    Kowalski, T.J.2    Zhang, Y.3    Elmquist, J.K.4    Lee, C.5    Kilimann, M.W.6
  • 35
    • 0033616795 scopus 로고    scopus 로고
    • Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
    • G.D. Demetri, C.D. Fletcher, E. Mueller, P. Sarraf, R. Naujoks, and N. Campbell Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma Proc Natl Acad Sci U S A 96 1999 3951 3956
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3951-3956
    • Demetri, G.D.1    Fletcher, C.D.2    Mueller, E.3    Sarraf, P.4    Naujoks, R.5    Campbell, N.6
  • 36
    • 66149179123 scopus 로고    scopus 로고
    • Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer
    • M.S. Denzel, L.W. Hebbard, G. Shostak, L. Shapiro, R.D. Cardiff, and B. Ranscht Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer Clin Cancer Res 15 2009 3256 3264
    • (2009) Clin Cancer Res , vol.15 , pp. 3256-3264
    • Denzel, M.S.1    Hebbard, L.W.2    Shostak, G.3    Shapiro, L.4    Cardiff, R.D.5    Ranscht, B.6
  • 37
    • 79953305102 scopus 로고    scopus 로고
    • Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
    • B. Dirat, L. Bochet, M. Dabek, D. Daviaud, S. Dauvillier, and B. Majed Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion Cancer Res 71 2011 2455 2465
    • (2011) Cancer Res , vol.71 , pp. 2455-2465
    • Dirat, B.1    Bochet, L.2    Dabek, M.3    Daviaud, D.4    Dauvillier, S.5    Majed, B.6
  • 38
    • 77957221459 scopus 로고    scopus 로고
    • Dynamic interplay between the collagen scaffold and tumor evolution
    • M. Egeblad, M.G. Rasch, and V.M. Weaver Dynamic interplay between the collagen scaffold and tumor evolution Curr Opin Cell Biol 22 2010 697 706
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 697-706
    • Egeblad, M.1    Rasch, M.G.2    Weaver, V.M.3
  • 40
    • 0016007951 scopus 로고
    • Tumor angiogenesis
    • J. Folkman Tumor angiogenesis Adv Cancer Res 19 1974 331 358
    • (1974) Adv Cancer Res , vol.19 , pp. 331-358
    • Folkman, J.1
  • 41
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • J. Folkman, K. Watson, D. Ingber, and D. Hanahan Induction of angiogenesis during the transition from hyperplasia to neoplasia Nature 339 1989 58 61
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 42
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, and S. Klein Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 56 2007 1010 1013
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 44
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 46
    • 79959466358 scopus 로고    scopus 로고
    • Minireview: IGF, insulin, and cancer
    • E.J. Gallagher, and D. LeRoith Minireview: IGF, insulin, and cancer Endocrinology 152 2011 2546 2551
    • (2011) Endocrinology , vol.152 , pp. 2546-2551
    • Gallagher, E.J.1    Leroith, D.2
  • 47
    • 0033935875 scopus 로고    scopus 로고
    • Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiinflammatory drugs: A pooled analysis of published studies and a new population-based study
    • L.A. Garcia Rodriguez, and C. Huerta-Alvarez Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiinflammatory drugs: a pooled analysis of published studies and a new population-based study Epidemiology 11 2000 376 381
    • (2000) Epidemiology , vol.11 , pp. 376-381
    • Garcia Rodriguez, L.A.1    Huerta-Alvarez, C.2
  • 48
    • 33645066625 scopus 로고    scopus 로고
    • Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: Possible role of obesity-related stimuli
    • C. Garofalo, M. Koda, S. Cascio, M. Sulkowska, L. Kanczuga-Koda, and J. Golaszewska Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli Clin Cancer Res 12 2006 1447 1453
    • (2006) Clin Cancer Res , vol.12 , pp. 1447-1453
    • Garofalo, C.1    Koda, M.2    Cascio, S.3    Sulkowska, M.4    Kanczuga-Koda, L.5    Golaszewska, J.6
  • 53
    • 3042711948 scopus 로고    scopus 로고
    • Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: A meta-analysis
    • A. Gonzalez-Perez, L.A. Garcia Rodriguez, and R. Lopez-Ridaura Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis BMC Cancer 3 2003 28
    • (2003) BMC Cancer , vol.3 , pp. 28
    • Gonzalez-Perez, A.1    Garcia Rodriguez, L.A.2    Lopez-Ridaura, R.3
  • 55
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 56
    • 79952996039 scopus 로고    scopus 로고
    • Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage
    • S.I. Grivennikov, and M. Karin Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage Ann Rheum Dis 70 Suppl. 1 2011 i104 i108
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 1
    • Grivennikov, S.I.1    Karin, M.2
  • 57
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • R.A. Gupta, and R.N. Dubois Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 Nat Rev Cancer 1 2001 11 21
    • (2001) Nat Rev Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 58
    • 33644877245 scopus 로고    scopus 로고
    • Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats
    • R. Hakkak, A.W. Holley, S.L. Macleod, P.M. Simpson, G.J. Fuchs, and C.H. Jo Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats Breast Cancer Res 7 2005 R627 R633
    • (2005) Breast Cancer Res , vol.7
    • Hakkak, R.1    Holley, A.W.2    Macleod, S.L.3    Simpson, P.M.4    Fuchs, G.J.5    Jo, C.H.6
  • 60
    • 33846653083 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma: A novel target for cancer therapeutics?
    • S. Han, and J. Roman Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics? Anticancer Drugs 18 2007 237 244
    • (2007) Anticancer Drugs , vol.18 , pp. 237-244
    • Han, S.1    Roman, J.2
  • 61
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • D. Hanahan, and L.M. Coussens Accessories to the crime: functions of cells recruited to the tumor microenvironment Cancer Cell 21 2012 309 322
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 62
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 63
    • 79960820132 scopus 로고    scopus 로고
    • The growing challenge of obesity and cancer: An inflammatory issue
    • A.E. Harvey, L.M. Lashinger, and S.D. Hursting The growing challenge of obesity and cancer: an inflammatory issue Ann N Y Acad Sci 1229 2011 45 52
    • (2011) Ann N y Acad Sci , vol.1229 , pp. 45-52
    • Harvey, A.E.1    Lashinger, L.M.2    Hursting, S.D.3
  • 64
    • 0032465074 scopus 로고    scopus 로고
    • A proposal for a new histological classification scheme for predicting short-term tumor recurrence and death in patients with invasive ductal carcinoma of the breast
    • T. Hasebe, S. Imoto, S. Sasaki, and K. Mukai A proposal for a new histological classification scheme for predicting short-term tumor recurrence and death in patients with invasive ductal carcinoma of the breast Jpn J Cancer Res 89 1998 1358 1373
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1358-1373
    • Hasebe, T.1    Imoto, S.2    Sasaki, S.3    Mukai, K.4
  • 65
    • 0033947545 scopus 로고    scopus 로고
    • New prognostic histological parameter of invasive ductal carcinoma of the breast: Clinicopathological significance of fibrotic focus
    • T. Hasebe, K. Mukai, H. Tsuda, and A. Ochiai New prognostic histological parameter of invasive ductal carcinoma of the breast: clinicopathological significance of fibrotic focus Pathol Int 50 2000 263 272
    • (2000) Pathol Int , vol.50 , pp. 263-272
    • Hasebe, T.1    Mukai, K.2    Tsuda, H.3    Ochiai, A.4
  • 66
    • 40449133794 scopus 로고    scopus 로고
    • T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model
    • L.W. Hebbard, M. Garlatti, L.J. Young, R.D. Cardiff, R.G. Oshima, and B. Ranscht T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model Cancer Res 68 2008 1407 1416
    • (2008) Cancer Res , vol.68 , pp. 1407-1416
    • Hebbard, L.W.1    Garlatti, M.2    Young, L.J.3    Cardiff, R.D.4    Oshima, R.G.5    Ranscht, B.6
  • 68
    • 84865429928 scopus 로고    scopus 로고
    • Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex i activity of the respiratory chain
    • A. Hirsch, D. Hahn, P. Kempna, G. Hofer, J.M. Nuoffer, and P.E. Mullis Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain Endocrinology 153 2012 4354 4366
    • (2012) Endocrinology , vol.153 , pp. 4354-4366
    • Hirsch, A.1    Hahn, D.2    Kempna, P.3    Hofer, G.4    Nuoffer, J.M.5    Mullis, P.E.6
  • 69
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 56 1996 4509 4515
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 71
    • 47649116414 scopus 로고    scopus 로고
    • Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells
    • M.R. Hoda, and G. Popken Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells BJU Int 102 2008 383 388
    • (2008) BJU Int , vol.102 , pp. 383-388
    • Hoda, M.R.1    Popken, G.2
  • 72
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • W.L. Holland, R.A. Miller, Z.V. Wang, K. Sun, B.M. Barth, and H.H. Bui Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin Nat Med 17 2011 55 63
    • (2011) Nat Med , vol.17 , pp. 55-63
    • Holland, W.L.1    Miller, R.A.2    Wang, Z.V.3    Sun, K.4    Barth, B.M.5    Bui, H.H.6
  • 73
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • G.S. Hotamisligil, P. Arner, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance J Clin Invest 95 1995 2409 2415
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 74
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 75
    • 78649484649 scopus 로고    scopus 로고
    • Leptin and gastro-intestinal malignancies
    • J.M. Howard, G.P. Pidgeon, and J.V. Reynolds Leptin and gastro-intestinal malignancies Obes Rev 11 2010 863 874
    • (2010) Obes Rev , vol.11 , pp. 863-874
    • Howard, J.M.1    Pidgeon, G.P.2    Reynolds, J.V.3
  • 76
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    • C. Hug, J. Wang, N.S. Ahmad, J.S. Bogan, T.S. Tsao, and H.F. Lodish T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin Proc Natl Acad Sci U S A 101 2004 10308 10313
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10308-10313
    • Hug, C.1    Wang, J.2    Ahmad, N.S.3    Bogan, J.S.4    Tsao, T.S.5    Lodish, H.F.6
  • 77
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • M. Ishikawa, J. Kitayama, and H. Nagawa Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer Clin Cancer Res 10 2004 4325 4331
    • (2004) Clin Cancer Res , vol.10 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 78
    • 0142103807 scopus 로고    scopus 로고
    • Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
    • P. Iyengar, T.P. Combs, S.J. Shah, V. Gouon-Evans, J.W. Pollard, and C. Albanese Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization Oncogene 22 2003 6408 6423
    • (2003) Oncogene , vol.22 , pp. 6408-6423
    • Iyengar, P.1    Combs, T.P.2    Shah, S.J.3    Gouon-Evans, V.4    Pollard, J.W.5    Albanese, C.6
  • 79
    • 20944447217 scopus 로고    scopus 로고
    • Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment
    • P. Iyengar, V. Espina, T.W. Williams, Y. Lin, D. Berry, and L.A. Jelicks Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment J Clin Invest 115 2005 1163 1176
    • (2005) J Clin Invest , vol.115 , pp. 1163-1176
    • Iyengar, P.1    Espina, V.2    Williams, T.W.3    Lin, Y.4    Berry, D.5    Jelicks, L.A.6
  • 81
    • 34447639114 scopus 로고    scopus 로고
    • Endothelial dysfunction in insulin resistance and type 2 diabetes
    • P.A. Jansson Endothelial dysfunction in insulin resistance and type 2 diabetes J Intern Med 262 2007 173 183
    • (2007) J Intern Med , vol.262 , pp. 173-183
    • Jansson, P.A.1
  • 82
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • T.D. Kanneganti, and V.D. Dixit Immunological complications of obesity Nat Immunol 13 2012 707 712
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 83
    • 33646504461 scopus 로고    scopus 로고
    • Adiponectin and cancer: A systematic review
    • I. Kelesidis, T. Kelesidis, and C.S. Mantzoros Adiponectin and cancer: a systematic review Br J Cancer 94 2006 1221 1225
    • (2006) Br J Cancer , vol.94 , pp. 1221-1225
    • Kelesidis, I.1    Kelesidis, T.2    Mantzoros, C.S.3
  • 84
  • 85
    • 84880924081 scopus 로고    scopus 로고
    • IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle
    • 10.1007/s00592-011-0259-z
    • T.H. Kim, S.E. Choi, E.S. Ha, J.G. Jung, S.J. Han, and H.J. Kim IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle Acta Diabetol 2011 10.1007/s00592-011-0259-z
    • (2011) Acta Diabetol
    • Kim, T.H.1    Choi, S.E.2    Ha, E.S.3    Jung, J.G.4    Han, S.J.5    Kim, H.J.6
  • 86
    • 80051504968 scopus 로고    scopus 로고
    • Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice
    • E.J. Kim, M.R. Choi, H. Park, M. Kim, J.E. Hong, and J.Y. Lee Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice Breast Cancer Res 13 2011 R78
    • (2011) Breast Cancer Res , vol.13 , pp. 78
    • Kim, E.J.1    Choi, M.R.2    Park, H.3    Kim, M.4    Hong, J.E.5    Lee, J.Y.6
  • 87
    • 0033673027 scopus 로고    scopus 로고
    • Scattered fat invasion: An indicator for poor prognosis in premenopausal, and for positive estrogen receptor in postmenopausal breast cancer patients
    • I. Kimijima, T. Ohtake, H. Sagara, T. Watanabe, and S. Takenoshita Scattered fat invasion: an indicator for poor prognosis in premenopausal, and for positive estrogen receptor in postmenopausal breast cancer patients Oncology 59 Suppl. 1 2000 25 30
    • (2000) Oncology , vol.59 , Issue.SUPPL. 1 , pp. 25-30
    • Kimijima, I.1    Ohtake, T.2    Sagara, H.3    Watanabe, T.4    Takenoshita, S.5
  • 88
    • 0037235020 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and cancers
    • H.P. Koeffler Peroxisome proliferator-activated receptor gamma and cancers Clin Cancer Res 9 2003 1 9
    • (2003) Clin Cancer Res , vol.9 , pp. 1-9
    • Koeffler, H.P.1
  • 92
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • M.S. Lee, C.C. Hsu, M.L. Wahlqvist, H.N. Tsai, Y.H. Chang, and Y.C. Huang Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals BMC Cancer 11 2011 20
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 93
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • K.R. Levental, H. Yu, L. Kass, J.N. Lakins, M. Egeblad, and J.T. Erler Matrix crosslinking forces tumor progression by enhancing integrin signaling Cell 139 2009 891 906
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3    Lakins, J.N.4    Egeblad, M.5    Erler, J.T.6
  • 94
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • G. Libby, L.A. Donnelly, P.T. Donnan, D.R. Alessi, A.D. Morris, and J.M. Evans New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diabetes Care 32 2009 1620 1625
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 95
  • 96
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • P. Lu, V.M. Weaver, and Z. Werb The extracellular matrix: a dynamic niche in cancer progression J Cell Biol 196 2012 395 406
    • (2012) J Cell Biol , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 97
    • 34548247242 scopus 로고    scopus 로고
    • The rapidly expanding family of adipokines
    • O.A. MacDougald, and C.F. Burant The rapidly expanding family of adipokines Cell Metab 6 2007 159 161
    • (2007) Cell Metab , vol.6 , pp. 159-161
    • Macdougald, O.A.1    Burant, C.F.2
  • 98
    • 0141892161 scopus 로고    scopus 로고
    • Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions
    • Y. Manabe, S. Toda, K. Miyazaki, and H. Sugihara Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions J Pathol 201 2003 221 228
    • (2003) J Pathol , vol.201 , pp. 221-228
    • Manabe, Y.1    Toda, S.2    Miyazaki, K.3    Sugihara, H.4
  • 99
    • 84055190706 scopus 로고    scopus 로고
    • Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells
    • U.E. Martinez-Outschoorn, R.G. Pestell, A. Howell, M.L. Tykocinski, F. Nagajyothi, and F.S. Machado Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells Cell Cycle 10 2011 4208 4216
    • (2011) Cell Cycle , vol.10 , pp. 4208-4216
    • Martinez-Outschoorn, U.E.1    Pestell, R.G.2    Howell, A.3    Tykocinski, M.L.4    Nagajyothi, F.5    Machado, F.S.6
  • 100
    • 58149506718 scopus 로고    scopus 로고
    • The role of fat topology in the risk of disease
    • Y. Matsuzawa The role of fat topology in the risk of disease Int J Obes 32 Suppl. 7 2008 S83 S92
    • (2008) Int J Obes , vol.32 , Issue.SUPPL. 7
    • Matsuzawa, Y.1
  • 101
    • 84862688466 scopus 로고    scopus 로고
    • Human adipose tissue macrophages display activation of cancer-related pathways
    • T.H. Mayi, M. Daoudi, B. Derudas, B. Gross, G. Bories, and K. Wouters Human adipose tissue macrophages display activation of cancer-related pathways J Biol Chem 287 2012 21904 21913
    • (2012) J Biol Chem , vol.287 , pp. 21904-21913
    • Mayi, T.H.1    Daoudi, M.2    Derudas, B.3    Gross, B.4    Bories, G.5    Wouters, K.6
  • 102
    • 44649124339 scopus 로고    scopus 로고
    • Food, nutrition, physical activity and cancer prevention. Authoritative report from World Cancer Research Fund provides global update
    • A.J. McMichael Food, nutrition, physical activity and cancer prevention. Authoritative report from World Cancer Research Fund provides global update Public Health Nutr 11 2008 762 763
    • (2008) Public Health Nutr , vol.11 , pp. 762-763
    • McMichael, A.J.1
  • 103
    • 61449148370 scopus 로고    scopus 로고
    • Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    • V. McMurtry, A.M. Simeone, R. Nieves-Alicea, and A.M. Tari Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells Clin Exp Metastasis 26 2009 197 204
    • (2009) Clin Exp Metastasis , vol.26 , pp. 197-204
    • McMurtry, V.1    Simeone, A.M.2    Nieves-Alicea, R.3    Tari, A.M.4
  • 104
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat Rev Cancer 7 2007 763 777
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 105
    • 0035266474 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: Mechanism of desmoplastic reaction
    • L. Meng, J. Zhou, H. Sasano, T. Suzuki, K.M. Zeitoun, and S.E. Bulun Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of desmoplastic reaction Cancer Res 61 2001 2250 2255
    • (2001) Cancer Res , vol.61 , pp. 2250-2255
    • Meng, L.1    Zhou, J.2    Sasano, H.3    Suzuki, T.4    Zeitoun, K.M.5    Bulun, S.E.6
  • 106
    • 77954154374 scopus 로고    scopus 로고
    • Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling
    • G. Migneco, D. Whitaker-Menezes, B. Chiavarina, R. Castello-Cros, S. Pavlides, and R.G. Pestell Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling Cell Cycle 9 2010 2412 2422
    • (2010) Cell Cycle , vol.9 , pp. 2412-2422
    • Migneco, G.1    Whitaker-Menezes, D.2    Chiavarina, B.3    Castello-Cros, R.4    Pavlides, S.5    Pestell, R.G.6
  • 107
    • 0006525096 scopus 로고    scopus 로고
    • Expression of leptin and leptin receptor isoforms in the human stomach
    • H. Mix, A. Widjaja, O. Jandl, M. Cornberg, A. Kaul, and M. Goke Expression of leptin and leptin receptor isoforms in the human stomach Gut 47 2000 481 486
    • (2000) Gut , vol.47 , pp. 481-486
    • Mix, H.1    Widjaja, A.2    Jandl, O.3    Cornberg, M.4    Kaul, A.5    Goke, M.6
  • 109
    • 54549116857 scopus 로고    scopus 로고
    • Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions
    • E.R. Motrescu, S. Blaise, N. Etique, N. Messaddeq, M.P. Chenard, and I. Stoll Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions Oncogene 27 2008 6347 6355
    • (2008) Oncogene , vol.27 , pp. 6347-6355
    • Motrescu, E.R.1    Blaise, S.2    Etique, N.3    Messaddeq, N.4    Chenard, M.P.5    Stoll, I.6
  • 110
    • 50849091591 scopus 로고    scopus 로고
    • Cancer cells, adipocytes and matrix metalloproteinase 11: A vicious tumor progression cycle
    • E.R. Motrescu, and M.C. Rio Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle Biol Chem 389 2008 1037 1041
    • (2008) Biol Chem , vol.389 , pp. 1037-1041
    • Motrescu, E.R.1    Rio, M.C.2
  • 111
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • H. Munzberg, and M.G. Myers Jr. Molecular and anatomical determinants of central leptin resistance Nat Neurosci 8 2005 566 570
    • (2005) Nat Neurosci , vol.8 , pp. 566-570
    • Munzberg, H.1    Myers, Jr.M.G.2
  • 112
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • C. Murdoch, M. Muthana, S.B. Coffelt, and C.E. Lewis The role of myeloid cells in the promotion of tumour angiogenesis Nat Rev Cancer 8 2008 618 631
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 114
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, and M. Ohsugi CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nat Med 15 2009 914 920
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 115
    • 73149109062 scopus 로고    scopus 로고
    • Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    • D.K. Nomura, J.Z. Long, S. Niessen, H.S. Hoover, S.W. Ng, and B.F. Cravatt Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Cell 140 2010 49 61
    • (2010) Cell , vol.140 , pp. 49-61
    • Nomura, D.K.1    Long, J.Z.2    Niessen, S.3    Hoover, H.S.4    Ng, S.W.5    Cravatt, B.F.6
  • 116
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • B. Ogretmen, and Y.A. Hannun Biologically active sphingolipids in cancer pathogenesis and treatment Nat Rev Cancer 4 2004 604 616
    • (2004) Nat Rev Cancer , vol.4 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 117
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • O. Osborn, and J.M. Olefsky The cellular and signaling networks linking the immune system and metabolism in disease Nat Med 18 2012 363 374
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 120
    • 80052178280 scopus 로고    scopus 로고
    • Paracrine and endocrine effects of adipose tissue on cancer development and progression
    • J. Park, D.M. Euhus, and P.E. Scherer Paracrine and endocrine effects of adipose tissue on cancer development and progression Endocr Rev 32 2011 550 570
    • (2011) Endocr Rev , vol.32 , pp. 550-570
    • Park, J.1    Euhus, D.M.2    Scherer, P.E.3
  • 121
    • 78650187530 scopus 로고    scopus 로고
    • Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo
    • J. Park, C.M. Kusminski, S.C. Chua, and P.E. Scherer Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo Am J Pathol 177 2010 3133 3144
    • (2010) Am J Pathol , vol.177 , pp. 3133-3144
    • Park, J.1    Kusminski, C.M.2    Chua, S.C.3    Scherer, P.E.4
  • 122
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • E.J. Park, J.H. Lee, G.Y. Yu, G. He, S.R. Ali, and R.G. Holzer Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression Cell 140 2010 197 208
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6
  • 123
    • 80052178858 scopus 로고    scopus 로고
    • Leptin and cancer: From cancer stem cells to metastasis
    • J. Park, and P.E. Scherer Leptin and cancer: from cancer stem cells to metastasis Endocr Relat Cancer 18 2011 C25 C29
    • (2011) Endocr Relat Cancer , vol.18
    • Park, J.1    Scherer, P.E.2
  • 124
    • 84868611621 scopus 로고    scopus 로고
    • Adipocyte-derived endotrophin promotes malignant tumor progression
    • J. Park, and P.E. Scherer Adipocyte-derived endotrophin promotes malignant tumor progression J Clin Invest 122 2012 4243 4256
    • (2012) J Clin Invest , vol.122 , pp. 4243-4256
    • Park, J.1    Scherer, P.E.2
  • 125
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • D. Patsouris, P.P. Li, D. Thapar, J. Chapman, J.M. Olefsky, and J.G. Neels Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals Cell Metab 8 2008 301 309
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 127
    • 43049123827 scopus 로고    scopus 로고
    • Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: Two case-control studies
    • E.T. Petridou, N. Mitsiades, S. Gialamas, M. Angelopoulos, A. Skalkidou, and N. Dessypris Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies Oncology 73 2007 261 269
    • (2007) Oncology , vol.73 , pp. 261-269
    • Petridou, E.T.1    Mitsiades, N.2    Gialamas, S.3    Angelopoulos, M.4    Skalkidou, A.5    Dessypris, N.6
  • 128
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • J.W. Pollard Tumour-educated macrophages promote tumour progression and metastasis Nat Rev Cancer 4 2004 71 78
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 131
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • B.Z. Qian, J. Li, H. Zhang, T. Kitamura, J. Zhang, and L.R. Campion CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis Nature 475 2011 222 225
    • (2011) Nature , vol.475 , pp. 222-225
    • Qian, B.Z.1    Li, J.2    Zhang, H.3    Kitamura, T.4    Zhang, J.5    Campion, L.R.6
  • 132
    • 77649183649 scopus 로고    scopus 로고
    • Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
    • S.J. Ralph, S. Rodriguez-Enriquez, J. Neuzil, and R. Moreno-Sanchez Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger Mol Aspects Med 31 2010 29 59
    • (2010) Mol Aspects Med , vol.31 , pp. 29-59
    • Ralph, S.J.1    Rodriguez-Enriquez, S.2    Neuzil, J.3    Moreno-Sanchez, R.4
  • 133
    • 37049013701 scopus 로고    scopus 로고
    • Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study
    • G.K. Reeves, K. Pirie, V. Beral, J. Green, E. Spencer, and D. Bull Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study BMJ 335 2007 1134
    • (2007) BMJ , vol.335 , pp. 1134
    • Reeves, G.K.1    Pirie, K.2    Beral, V.3    Green, J.4    Spencer, E.5    Bull, D.6
  • 134
    • 70349741579 scopus 로고    scopus 로고
    • Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer
    • R. Rene Gonzalez, A. Watters, Y. Xu, U.P. Singh, D.R. Mann, and B.R. Rueda Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer Breast Cancer Res 11 2009 R36
    • (2009) Breast Cancer Res , vol.11 , pp. 36
    • Rene Gonzalez, R.1    Watters, A.2    Xu, Y.3    Singh, U.P.4    Mann, D.R.5    Rueda, B.R.6
  • 135
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • A.G. Renehan, M. Tyson, M. Egger, R.F. Heller, and M. Zwahlen Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies Lancet 371 2008 569 578
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 136
    • 15244340583 scopus 로고    scopus 로고
    • From a unique cell to metastasis is a long way to go: Clues to stromelysin-3 participation
    • M.C. Rio From a unique cell to metastasis is a long way to go: clues to stromelysin-3 participation Biochimie 87 2005 299 306
    • (2005) Biochimie , vol.87 , pp. 299-306
    • Rio, M.C.1
  • 137
    • 84875223431 scopus 로고    scopus 로고
    • The role of Cancer-Associated Adipocytes (CAA) in the dynamic interaction between the tumor and the host
    • M.M. Mueller, N.E. Fusenig, Springer Netherlands
    • M.-C. Rio The role of Cancer-Associated Adipocytes (CAA) in the dynamic interaction between the tumor and the host M.M. Mueller, N.E. Fusenig, Tumor-Associated Fibroblasts and their Matrix Vol. 4 2011 Springer Netherlands 111 123
    • (2011) Tumor-Associated Fibroblasts and Their Matrix , vol.4 , pp. 111-123
    • Rio, M.-C.1
  • 139
    • 0346220288 scopus 로고    scopus 로고
    • Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes
    • H. Ruan, M.J. Zarnowski, S.W. Cushman, and H.F. Lodish Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes J Biol Chem 278 2003 47585 47593
    • (2003) J Biol Chem , vol.278 , pp. 47585-47593
    • Ruan, H.1    Zarnowski, M.J.2    Cushman, S.W.3    Lodish, H.F.4
  • 140
    • 0034654120 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible implications for breast cancer therapy
    • G.L. Rubin, Y. Zhao, A.M. Kalus, and E.R. Simpson Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy Cancer Res 60 2000 1604 1608
    • (2000) Cancer Res , vol.60 , pp. 1604-1608
    • Rubin, G.L.1    Zhao, Y.2    Kalus, A.M.3    Simpson, E.R.4
  • 141
    • 70349484670 scopus 로고    scopus 로고
    • Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue
    • J.M. Rutkowski, K.E. Davis, and P.E. Scherer Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue FEBS J 276 2009 5738 5746
    • (2009) FEBS J , vol.276 , pp. 5738-5746
    • Rutkowski, J.M.1    Davis, K.E.2    Scherer, P.E.3
  • 142
    • 0036319584 scopus 로고    scopus 로고
    • To block estrogen's synthesis or action: That is the question
    • R.J. Santen To block estrogen's synthesis or action: that is the question J Clin Endocrinol Metab 87 2002 3007 3012
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3007-3012
    • Santen, R.J.1
  • 143
    • 67449136137 scopus 로고    scopus 로고
    • History of aromatase: Saga of an important biological mediator and therapeutic target
    • R.J. Santen, H. Brodie, E.R. Simpson, P.K. Siiteri, and A. Brodie History of aromatase: saga of an important biological mediator and therapeutic target Endocr Rev 30 2009 343 375
    • (2009) Endocr Rev , vol.30 , pp. 343-375
    • Santen, R.J.1    Brodie, H.2    Simpson, E.R.3    Siiteri, P.K.4    Brodie, A.5
  • 144
    • 33746069082 scopus 로고    scopus 로고
    • In memoriam of Rudolf virchow: A historical retrospective including aspects of inflammation, infection and neoplasia
    • A. Schmidt, and O.F. Weber In memoriam of Rudolf virchow: a historical retrospective including aspects of inflammation, infection and neoplasia Contrib Microbiol 13 2006 1 15
    • (2006) Contrib Microbiol , vol.13 , pp. 1-15
    • Schmidt, A.1    Weber, O.F.2
  • 145
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • G.L. Semenza Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy Trends Pharmacol Sci 33 2012 207 214
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 148
  • 149
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signalling lipid
    • S. Spiegel, and S. Milstien Sphingosine-1-phosphate: an enigmatic signalling lipid Nat Rev Mol Cell Biol 4 2003 397 407
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 150
    • 79957916782 scopus 로고    scopus 로고
    • Adipose tissue remodeling and obesity
    • K. Sun, C.M. Kusminski, and P.E. Scherer Adipose tissue remodeling and obesity J Clin Invest 121 2011 2094 2101
    • (2011) J Clin Invest , vol.121 , pp. 2094-2101
    • Sun, K.1    Kusminski, C.M.2    Scherer, P.E.3
  • 152
    • 34047141622 scopus 로고    scopus 로고
    • Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells
    • C. Takahata, Y. Miyoshi, N. Irahara, T. Taguchi, Y. Tamaki, and S. Noguchi Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells Cancer Lett 250 2007 229 236
    • (2007) Cancer Lett , vol.250 , pp. 229-236
    • Takahata, C.1    Miyoshi, Y.2    Irahara, N.3    Taguchi, T.4    Tamaki, Y.5    Noguchi, S.6
  • 153
    • 33745177371 scopus 로고    scopus 로고
    • Expression of adiponectin receptors and its possible implication in the human endometrium
    • Y. Takemura, Y. Osuga, T. Yamauchi, M. Kobayashi, M. Harada, and T. Hirata Expression of adiponectin receptors and its possible implication in the human endometrium Endocrinology 147 2006 3203 3210
    • (2006) Endocrinology , vol.147 , pp. 3203-3210
    • Takemura, Y.1    Osuga, Y.2    Yamauchi, T.3    Kobayashi, M.4    Harada, M.5    Hirata, T.6
  • 154
    • 84868671526 scopus 로고    scopus 로고
    • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    • S. Talukdar, D.Y. Oh, G. Bandyopadhyay, D. Li, J. Xu, and J. McNelis Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase Nat Med 18 2012 1407 1412
    • (2012) Nat Med , vol.18 , pp. 1407-1412
    • Talukdar, S.1    Oh, D.Y.2    Bandyopadhyay, G.3    Li, D.4    Xu, J.5    McNelis, J.6
  • 155
    • 82555201367 scopus 로고    scopus 로고
    • Adipocyte is a non-trivial, dynamic partner of breast cancer cells
    • J. Tan, E. Buache, M.P. Chenard, N. Dali-Youcef, and M.C. Rio Adipocyte is a non-trivial, dynamic partner of breast cancer cells Int J Dev Biol 55 2011 851 859
    • (2011) Int J Dev Biol , vol.55 , pp. 851-859
    • Tan, J.1    Buache, E.2    Chenard, M.P.3    Dali-Youcef, N.4    Rio, M.C.5
  • 156
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • M.J. Thun, M.M. Namboodiri, and C.W. Heath Jr. Aspirin use and reduced risk of fatal colon cancer N Engl J Med 325 1991 1593 1596
    • (1991) N Engl J Med , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, Jr.C.W.3
  • 157
    • 0036830917 scopus 로고    scopus 로고
    • Cachexia in cancer patients
    • M.J. Tisdale Cachexia in cancer patients Nat Rev Cancer 2 2002 862 871
    • (2002) Nat Rev Cancer , vol.2 , pp. 862-871
    • Tisdale, M.J.1
  • 158
    • 12644265334 scopus 로고    scopus 로고
    • Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
    • P. Tontonoz, S. Singer, B.M. Forman, P. Sarraf, J.A. Fletcher, and C.D. Fletcher Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor Proc Natl Acad Sci U S A 94 1997 237 241
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 237-241
    • Tontonoz, P.1    Singer, S.2    Forman, B.M.3    Sarraf, P.4    Fletcher, J.A.5    Fletcher, C.D.6
  • 159
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • P. Tontonoz, and B.M. Spiegelman Fat and beyond: the diverse biology of PPARgamma Annu Rev Biochem 77 2008 289 312
    • (2008) Annu Rev Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 160
    • 47849121225 scopus 로고    scopus 로고
    • Hypoxia in adipose tissue: A basis for the dysregulation of tissue function in obesity?
    • P. Trayhurn, B. Wang, and I.S. Wood Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 100 2008 227 235
    • (2008) Br J Nutr , vol.100 , pp. 227-235
    • Trayhurn, P.1    Wang, B.2    Wood, I.S.3
  • 161
    • 13244284806 scopus 로고    scopus 로고
    • Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
    • M.E. Trujillo, and P.E. Scherer Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome J Intern Med 257 2005 167 175
    • (2005) J Intern Med , vol.257 , pp. 167-175
    • Trujillo, M.E.1    Scherer, P.E.2
  • 162
    • 0032910549 scopus 로고    scopus 로고
    • Expression of leptin receptor in lung: Leptin as a growth factor
    • T. Tsuchiya, H. Shimizu, T. Horie, and M. Mori Expression of leptin receptor in lung: leptin as a growth factor Eur J Pharmacol 365 1999 273 279
    • (1999) Eur J Pharmacol , vol.365 , pp. 273-279
    • Tsuchiya, T.1    Shimizu, H.2    Horie, T.3    Mori, M.4
  • 163
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: Mechanistic insights and clinical implications
    • A.T. Turer, and P.E. Scherer Adiponectin: mechanistic insights and clinical implications Diabetologia 55 2012 2319 2326
    • (2012) Diabetologia , vol.55 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 164
    • 0036701556 scopus 로고    scopus 로고
    • Weight control and physical activity in cancer prevention: International evaluation of the evidence
    • H. Vainio, R. Kaaks, and F. Bianchini Weight control and physical activity in cancer prevention: international evaluation of the evidence Eur J Cancer Prev 11 Suppl. 2 2002 S94 S100
    • (2002) Eur J Cancer Prev , vol.11 , Issue.SUPPL. 2
    • Vainio, H.1    Kaaks, R.2    Bianchini, F.3
  • 166
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • P. Vaupel, and A. Mayer Hypoxia in cancer: significance and impact on clinical outcome Cancer Metastasis Rev 26 2007 225 239
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 167
    • 78049281029 scopus 로고    scopus 로고
    • Adipose tissue endothelial cells from obese human subjects: Differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence
    • A. Villaret, J. Galitzky, P. Decaunes, D. Esteve, M.A. Marques, and C. Sengenes Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence Diabetes 59 2010 2755 2763
    • (2010) Diabetes , vol.59 , pp. 2755-2763
    • Villaret, A.1    Galitzky, J.2    Decaunes, P.3    Esteve, D.4    Marques, M.A.5    Sengenes, C.6
  • 168
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • B. Visentin, J.A. Vekich, B.J. Sibbald, A.L. Cavalli, K.M. Moreno, and R.G. Matteo Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages Cancer Cell 9 2006 225 238
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1    Vekich, J.A.2    Sibbald, B.J.3    Cavalli, A.L.4    Moreno, K.M.5    Matteo, R.G.6
  • 169
    • 84864391107 scopus 로고    scopus 로고
    • Adipose tissue and breast epithelial cells: A dangerous dynamic duo in breast cancer
    • Y.Y. Wang, C. Lehuede, V. Laurent, B. Dirat, S. Dauvillier, and L. Bochet Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer Cancer Lett 324 2012 142 151
    • (2012) Cancer Lett , vol.324 , pp. 142-151
    • Wang, Y.Y.1    Lehuede, C.2    Laurent, V.3    Dirat, B.4    Dauvillier, S.5    Bochet, L.6
  • 170
    • 0033794850 scopus 로고    scopus 로고
    • Human leptin: From an adipocyte hormone to an endocrine mediator
    • M. Wauters, R.V. Considine, and L.F. Van Gaal Human leptin: from an adipocyte hormone to an endocrine mediator Eur J Endocrinol 143 2000 293 311
    • (2000) Eur J Endocrinol , vol.143 , pp. 293-311
    • Wauters, M.1    Considine, R.V.2    Van Gaal, L.F.3
  • 171
    • 60749137629 scopus 로고    scopus 로고
    • PPARgamma-independent antitumor effects of thiazolidinediones
    • S. Wei, J. Yang, S.L. Lee, S.K. Kulp, and C.S. Chen PPARgamma-independent antitumor effects of thiazolidinediones Cancer Lett 276 2009 119 124
    • (2009) Cancer Lett , vol.276 , pp. 119-124
    • Wei, S.1    Yang, J.2    Lee, S.L.3    Kulp, S.K.4    Chen, C.S.5
  • 172
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: Molecular pathways and therapeutic targets
    • S.M. Weis, and D.A. Cheresh Tumor angiogenesis: molecular pathways and therapeutic targets Nat Med 17 2011 1359 1370
    • (2011) Nat Med , vol.17 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 175
    • 79957922046 scopus 로고    scopus 로고
    • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    • D. Whitaker-Menezes, U.E. Martinez-Outschoorn, Z. Lin, A. Ertel, N. Flomenberg, and A.K. Witkiewicz Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts Cell Cycle 10 2011 1772 1783
    • (2011) Cell Cycle , vol.10 , pp. 1772-1783
    • Whitaker-Menezes, D.1    Martinez-Outschoorn, U.E.2    Lin, Z.3    Ertel, A.4    Flomenberg, N.5    Witkiewicz, A.K.6
  • 176
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, and C.J. Chou Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 2003 1821 1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 177
    • 51349123575 scopus 로고    scopus 로고
    • Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast
    • J. Yamaguchi, H. Ohtani, K. Nakamura, I. Shimokawa, and T. Kanematsu Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast Am J Clin Pathol 130 2008 382 388
    • (2008) Am J Clin Pathol , vol.130 , pp. 382-388
    • Yamaguchi, J.1    Ohtani, H.2    Nakamura, K.3    Shimokawa, I.4    Kanematsu, T.5
  • 178
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, and S. Kita Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1    Kamon, J.2    Ito, Y.3    Tsuchida, A.4    Yokomizo, T.5    Kita, S.6
  • 179
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • C. Yang, J. Sudderth, T. Dang, R.M. Bachoo, J.G. McDonald, and R.J. DeBerardinis Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling Cancer Res 69 2009 7986 7993
    • (2009) Cancer Res , vol.69 , pp. 7986-7993
    • Yang, C.1    Sudderth, J.2    Dang, T.3    Bachoo, R.M.4    McDonald, J.G.5    Deberardinis, R.J.6
  • 180
    • 84868529715 scopus 로고    scopus 로고
    • Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis
    • E. Yehuda-Shnaidman, and B. Schwartz Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis Obes Rev 13 2012 1083 1095
    • (2012) Obes Rev , vol.13 , pp. 1083-1095
    • Yehuda-Shnaidman, E.1    Schwartz, B.2
  • 181
    • 54549087818 scopus 로고    scopus 로고
    • Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue
    • K. Yoneda, A. Tomimoto, H. Endo, H. Iida, M. Sugiyama, and H. Takahashi Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue Oncol Rep 20 2008 479 483
    • (2008) Oncol Rep , vol.20 , pp. 479-483
    • Yoneda, K.1    Tomimoto, A.2    Endo, H.3    Iida, H.4    Sugiyama, M.5    Takahashi, H.6
  • 182
    • 81855209246 scopus 로고    scopus 로고
    • Adipose tissue-derived progenitor cells and cancer
    • Y. Zhang, C.F. Bellows, and M.G. Kolonin Adipose tissue-derived progenitor cells and cancer World J Stem Cells 2 2010 103 113
    • (2010) World J Stem Cells , vol.2 , pp. 103-113
    • Zhang, Y.1    Bellows, C.F.2    Kolonin, M.G.3
  • 183
    • 84867546345 scopus 로고    scopus 로고
    • Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment
    • Y. Zhang, A.C. Daquinag, F. Amaya-Manzanares, O. Sirin, C. Tseng, and M.G. Kolonin Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment Cancer Res 72 2012 5198 5208
    • (2012) Cancer Res , vol.72 , pp. 5198-5208
    • Zhang, Y.1    Daquinag, A.C.2    Amaya-Manzanares, F.3    Sirin, O.4    Tseng, C.5    Kolonin, M.G.6
  • 184
    • 80052155796 scopus 로고    scopus 로고
    • Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival
    • Q. Zheng, S.M. Dunlap, J. Zhu, E. Downs-Kelly, J. Rich, and S.D. Hursting Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival Endocr Relat Cancer 18 2011 491 503
    • (2011) Endocr Relat Cancer , vol.18 , pp. 491-503
    • Zheng, Q.1    Dunlap, S.M.2    Zhu, J.3    Downs-Kelly, E.4    Rich, J.5    Hursting, S.D.6
  • 185
    • 34248211595 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells
    • W. Zhou, W.F. Han, L.E. Landree, J.N. Thupari, M.L. Pinn, and T. Bililign Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells Cancer Res 67 2007 2964 2971
    • (2007) Cancer Res , vol.67 , pp. 2964-2971
    • Zhou, W.1    Han, W.F.2    Landree, L.E.3    Thupari, J.N.4    Pinn, M.L.5    Bililign, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.