Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

Oncogene

Volumn 22, Issue 41, 2003, Pages 6408-6423

  Iyengar, Puneeth ^a   Combs, Terry P ^a   Shah, Shalin J ^a   Gouon Evans, Valérie ^a   Pollard, Jeffrey W ^a   Albanese, Chris ^b   Flanagan, Louise ^c   Tenniswood, Martin P ^c   Guha, Chandan ^a   Lisanti, Michael P ^a   Pestell, Richard G ^b   Scherer, Philipp E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Adipocytes; Breast cancer; Heterotypic signaling; Stromal cells; Type VI collagen

Indexed keywords

ADIPOCYTOKINE; BETA CATENIN; COLLAGEN TYPE 4; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; P 18; PROTEIN; PROTEIN FOS; PROTEIN INHIBITOR; PROTEIN KINASE; RESISTIN; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CATNB PROTEIN, MOUSE; COLLAGEN TYPE 6; CYTOSKELETON PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; TRANSACTIVATOR PROTEIN;

ADIPOCYTE; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST DUCT; CARCINOGENESIS; CELL CYCLE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN MCF 7; CELL TRANSFORMATION; CONTROLLED STUDY; DNA MICROARRAY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HOST; HUMAN; HUMAN CELL; IN VIVO STUDY; MAMMARY GLAND; MOLECULAR MECHANICS; MOLECULE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTO ONCOGENE; REGULATORY MECHANISM; REPORTER GENE; SOLUBILITY; TUMOR; UPREGULATION; ANIMAL; CELL MOTION; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PROMOTER REGION; SECRETION;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

ADIPOCYTES; ANIMALS; APOPTOSIS; BETA CATENIN; CELL MOVEMENT; COLLAGEN TYPE VI; CYTOSKELETAL PROTEINS; FLOW CYTOMETRY; GLYCOGEN SYNTHASE KINASE 3; MICE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENES; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0142103807     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206737     Document Type: Article

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