MPTP activates c-Jun NH2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1200-1208

  Saporito, Michael S ^a   Thomas, Beth Ann ^a   Scott, Richard W ^a  

^a CEPHALON INC   (United States)

Author keywords

Apoptosis; c Jun NH2 terminal kinase; c Jun NH2 terminal kinase kinase; Mpp+; MPTP; Parkinson's disease; Phosphorylated c Jun NH2 terminal kinase; Phosphorylated c Jun NH2 terminal kinase kinase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CARBAZOLES; CORPUS STRIATUM; ENZYME ACTIVATION; ENZYME INHIBITORS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; SELEGILINE; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 0033840581     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751200.x     Document Type: Article

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