Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-α expression

Toxicology in Vitro

Volumn 25, Issue 5, 2011, Pages 1039-1044

  Dholakiya, Sanjay L ^a   Benzeroual, Kenza E ^a  

^a LONG ISLAND UNIVERSITY   (United States)

Author keywords

Apoptosis; Diosmin; Lipopolysaccharide (LPS); Neurodegeneration; Neuroinflammation; PC12 cells; TNF

Indexed keywords

CASPASE 3; DIOSMIN; LIPOPOLYSACCHARIDE; PROTEIN BAD; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CASPASE 3; DIOSMIN; DNA FRAGMENTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; LIPOPOLYSACCHARIDES; NEURONS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79957939863     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.04.003     Document Type: Article

References (37)

1. Anisman H., Merali Z., Hayley S. Neurotransmitter peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog. Neurobiol. 2008, 85(1):1-74.
2. Ansari N., Khodagholi F., Amini M., Shaerzadeh F. Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative. Biochimie 2011, 93(5):899-908.
3. Beecher G.R. Overview of dietary flavonoids: nomenclature, occurrence and intake. J. Nutr. 2003, 133(32):3248S-3254S.
4. Blasko I., Marx F., Steiner E., Hartmann T., Grubeck-Loebenstein B. TNF-alpha plus IFN gamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J. 1999, 13:63-68.
5. Calissano P., Matrone C., Amadoro G. Apoptosis and in vitro Alzheimer disease neuronal models. Commun. Integr. Biol. 2009, 2:163-169.
6. Camarda L., Di Stefano V., Del Bosco S.F., Schillaci D. Antiproliferative activity of citrus juices and HPLC evaluation of their flavonoid composition. Fitoterapia 2007, 78:426-429.
7. Campanero M.A., Escolar M., Garcia-Quetglas P., Sadaba B., Azanza J.R. Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography - Atmospheric pressure chemical ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J. Pharm. Biomed. Anal. 2010, 51(4):875-881.
8. Cesarone M.R., Belcaro G., Pellegrini L., Ledda A., Vinciguerra G., Ricci A., Di Renzo A., Ruffini I., Gizzi G., Ippolito E., Fano F., Dugall M., Acerbi G., Cornelli U., Hosoi M., Cacchio M. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology 2006, 57(3):331-339.
9. Crespo M.E., Galvez J., Cruz T., Ocete M.A., Zarzuelo A. Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Med. 1999, 65:651-653.
10. Culpan D., Cram K., Chalmers A., Cornish L., Palmer J., Palmer A., Hughes P., Passmore D., Craigs G.K., Wilcock P.G., Kehoe, Love S. Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease. Exp. Gerontol. 2007, 42:538-544.
11. Del Bano M.J., Lorente J., Castillo J., Benavente-Garcia O., Marin M.P., Del Rio J.A., Ortuno A., Ibarra I. Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Postulation of a biosynthetic pathway. J. Agric. Food Chem. 2004, 52(6):4987-4992.
12. Girish V., Vijayalakshmi A. Affordable image analysis using NIH Image/ImageJ. Indian J. Cancer 2004, 41:47.
13. Guha M., Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 2001, 1:85-94.
14. Guillot R., Ogneva V., Hadjiisky P., Kassab J.P., Andre J., Mozère G., Peyroux J., Sternberg M. Effect of long-term treatment with a purified micronized flavonoid fraction on pancreatic mononuclear cell infiltration in diabetic BB rats. Pancreas 1998, 17(3):301-308.
15. Huang Y.H., Chang A.Y., Huang C.M., Huang S.W., Chan S.H. Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells. Proteomics 2002, 2:1220-1228.
16. Jean T., Bodinier M.C. Mediators involved in inflammation: effects of Daflon 500mg on their release. Angiology 1994, 45:554-559.
17. Klegeris A., Walker D.G., McGeer P.L. Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha. Brain Res. 1997, 747:114-121.
18. Korsmeyer S.J., Shutter J.R., Veis D.J., Merry D.E., Oltvai Z.N. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death, Semin. Cancer Biol. 1993, 4:327-332.
19. Kuntz S., Wenzel U., Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 1999, 38:133-142.
20. Le Marchand L., Murphy S.P., Hankin J.H., Wilkens L.R., Kolonel L.N. Intake of flavonoids and lung cancer. J. Nat. Cancer Inst. 2000, 92:154-160.
21. Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997, 89:175-184.
22. McGeer E.G., McGeer P.L. Inflammatory processes in Alzheimer's disease. Prog. Neuropsycho. pharmacol. Biol. Psychiatry 2003, 27:741-749.
23. Middleton E., Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem. Pharmacol. 1992, 43:1167-1179.
24. Middleton E., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52:673-751.
25. Miller D.K. The role of caspase family of cysteine proteases in apoptosis. Semin. Immunol. 1997, 9:35-49.
26. Nogata Y., Sakamoto K., Shiratsuchi H., Ishii T., Yano M., Ohta H. Flavonoid composition of fruit tissues of citrus species. Biosci. Biotechnol. Biochem. 2006, 70:178-192.
27. Sharifi A.M., Hoda F.E., Noor A.M. Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and caspase-3 protein expression. Toxicol. Mech. Methods 2010, 20(6):316-320.
28. Shepherd C., Thiel E., McCann H., Harding A.J., Halliday G.M. Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies. Arch. Neurol. 2000, 57(6):817-822.
29. Shimohama S. Apoptosis in Alzheimer's disease - An update. Apoptosis 2000, 5:9-16.
30. Tarkowski E., Liljeroth A.M., Minthon L., Tardowski A., Wallin A., Blennow K. Cerebral pattern of pro- and anti-inflammatory cytokines in dementias. Brain Res. Bull. 2003, 61(3):255-260.
31. Togbe D., Schnyder-Candrian S., Schnyder B., Doz E., Noulin N., Janot L., Secher T., Gasse P., Lima C., Coelho F.R., Vasseur V., Erard F., Ryffel B., Couillin I., Moser R. Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int. J. Exp. Pathol. 2007, 88:387-391.
32. Tweedie D., Sambamurti K., Greig N.H. TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr. Alzheimer Res. 2007, 4:378-385.
33. Wang, M., Chen, Y., Zhang, Y., Zhang, L., Lu, X., Chen, Z., 2011. Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell. Mol. Immunol. 7 [Epub ahead of print].
34. Wong P.M.C., Chung S.W., Sultzer B.M. Genes, receptors, signals and responses to lipopolysaccharide endotoxin. Scand. J. Immunol. 2000, 51:123-127.
35. Yang M., Tanaka T., Hirose Y., Deguchi T., Mori H., Kawada Y. Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. Int. J. Cancer. 1997, 73:719-724.
36. Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Vinters H.V., Frautschy S.A., Cole G.M. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol. 1998, 152:379-389.
37. Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature 2000, 407:802-809.