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Volumn 93, Issue 5, 2011, Pages 899-908

Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative

Author keywords

Apoptosis; LPS; NF B; Oxazine derivative; PC12 cells

Indexed keywords

2 ETHOXY 4,5 DIPHENYL 1,3 OXAZINE 6 ONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACRIDINE ORANGE; CASPASE 3; ETHIDIUM BROMIDE; GAMMA GLUTAMYLCYSTEINE; HEAT SHOCK PROTEIN 32; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NERVE GROWTH FACTOR; OXAZINE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 79953869870     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.01.012     Document Type: Article
Times cited : (31)

References (52)
  • 1
    • 0034018813 scopus 로고    scopus 로고
    • Apoptosis in Alzheimer's diseasedan update
    • S. Shimohama, Apoptosis in Alzheimer's diseasedan update, Apoptosis 5 (2000) 9-16.
    • (2000) Apoptosis , vol.5 , pp. 9-16
    • Shimohama, S.1
  • 2
    • 0031930313 scopus 로고    scopus 로고
    • Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease
    • F. Yang, X. Sun, W. Beech, B. Teter, S. Wu, J. Sigel, H.V. Vinters, S.A. Frautschy, G.M. Cole, Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease, Am. J. Pathol. 152 (1998) 379-389.
    • (1998) Am. J. Pathol. , vol.152 , pp. 379-389
    • Yang, F.1    Sun, X.2    Beech, W.3    Teter, B.4    Wu, S.5    Sigel, J.6    Vinters, H.V.7    Frautschy, S.A.8    Cole, G.M.9
  • 3
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • DOI 10.1016/S0898-6568(00)00149-2, PII S0898656800001492
    • M. Guha, N. Mackman, LPS induction of gene expression in human monocytes, Cell Signal. 13 (2001) 85-94. (Pubitemid 32222977)
    • (2001) Cellular Signalling , vol.13 , Issue.2 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 4
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • E. Zandi, D.M. Rothwarf, M. Delhase, M. Hayakawa, M. Karin, The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation, Cell 91 (1997) 243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 5
    • 19444377638 scopus 로고    scopus 로고
    • Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NFkappaB signaling pathway
    • J.H. Jang, Y.J. Surh, Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NFkappaB signaling pathway, Free Radic. Biol. Med. 38 (2005) 1604-1613.
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 1604-1613
    • Jang, J.H.1    Surh, Y.J.2
  • 6
    • 41949141296 scopus 로고    scopus 로고
    • NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
    • G.H. Liu, J. Qu, X. Shen, NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK, Biochim. Biophys. Acta 1783 (2008) 713-727.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 713-727
    • Liu, G.H.1    Qu, J.2    Shen, X.3
  • 7
    • 1942520367 scopus 로고    scopus 로고
    • Nrf2 signaling in coordinated activation of antioxidant gene expression
    • A.K. Jaiswal, Nrf2 signaling in coordinated activation of antioxidant gene expression, Free Radic. Biol. Med 36 (2004) 1199-1207.
    • (2004) Free Radic. Biol. Med , vol.36 , pp. 1199-1207
    • Jaiswal, A.K.1
  • 8
    • 70349734681 scopus 로고    scopus 로고
    • Molecular shape analysis of antioxidant and squalene synthase inhibitory activities of aromatic tetrahydro-1,4-oxazine derivatives
    • K. Roy, I. Mitra, A. Saha, Molecular shape analysis of antioxidant and squalene synthase inhibitory activities of aromatic tetrahydro-1,4-oxazine derivatives, Chem. Biol. Drug Des. 74 (2009) 507-516.
    • (2009) Chem. Biol. Drug Des. , vol.74 , pp. 507-516
    • Roy, K.1    Mitra, I.2    Saha, A.3
  • 9
    • 0014439172 scopus 로고
    • Synthesis and antiinflammatory activity of 2-aryl-2-alpha-piperidyl-1,3- dioxanes
    • P. Aeberli, W.J. Houlihan, E.I. Takesue, Synthesis and antiinflammatory activity of 2-aryl-2-alpha-piperidyl-1,3-dioxanes, J. Med. Chem. 12 (1969) 51-54.
    • (1969) J. Med. Chem. , vol.12 , pp. 51-54
    • Aeberli, P.1    Houlihan, W.J.2    Takesue, E.I.3
  • 11
    • 72849161878 scopus 로고
    • The neurosedative effect of N-(3,4,5-trimethoxybenzoyl)-tetrahydro-1,4- oxazine [trioxazin, compound V-7.]
    • J. Borsy, The neurosedative effect of N-(3,4,5-trimethoxybenzoyl)- tetrahydro-1,4-oxazine [trioxazin, compound V-7.], Arch. Int. Pharmacodyn. Ther. 126 (1960) 426-453.
    • (1960) Arch. Int. Pharmacodyn. Ther. , vol.126 , pp. 426-453
    • Borsy, J.1
  • 12
    • 1542613792 scopus 로고    scopus 로고
    • Computational studies of COX-2 inhibitors: 3D-QSAR and docking
    • DOI 10.1016/j.bmc.2004.01.027, PII S0968089604000604
    • H.J. Kim, C.H. Chae, K.Y. Yi, K.L. Park, S.E. Yoo, Computational studies of COX-2 inhibitors: 3D-QSAR and docking, Bioorg. Med. Chem. 12 (2004) 1629-1641. (Pubitemid 38340760)
    • (2004) Bioorganic and Medicinal Chemistry , vol.12 , Issue.7 , pp. 1629-1641
    • Kim, H.-J.1    Chae, C.H.2    Yi, K.Y.3    Park, K.-L.4    Yoo, S.-E.5
  • 13
    • 79953793003 scopus 로고    scopus 로고
    • Synthesis of 2,2-dialkoxy-4,5-diaryl-2,3-dihydro-6H-1,3-oxazin-6-one and 2-ethoxy-2-ethylthio-4,5-diphenyl-2,3-dihydro-6H- 1,3-oxazin-6-one
    • A. Assadieskandar, M. Amini, A. Shafiee, Synthesis of 2,2-dialkoxy-4,5-diaryl-2,3-dihydro-6H-1,3-oxazin-6-one and 2-ethoxy-2- ethylthio-4,5-diphenyl-2,3-dihydro-6H- 1,3-oxazin-6-one, Turk. J. Chem. 34 (2010) 1-7.
    • (2010) Turk. J. Chem. , vol.34 , pp. 1-7
    • Assadieskandar, A.1    Amini, M.2    Shafiee, A.3
  • 14
    • 0031833250 scopus 로고    scopus 로고
    • Pulmonary fibrosis. Cytokines in the balance
    • R.K. Coker, G.J. Laurent, Pulmonary fibrosis. Cytokines in the balance, Eur. Respir. J. 11 (1998) 1218-1221.
    • (1998) Eur. Respir. J. , vol.11 , pp. 1218-1221
    • Coker, R.K.1    Laurent, G.J.2
  • 15
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.1
  • 16
    • 0345306813 scopus 로고    scopus 로고
    • Aspirin prevents apoptosis and NFkappaB activation induced by H2O2 in HeLa cells
    • O. Kutuk, H. Basaga, Aspirin prevents apoptosis and NFkappaB activation induced by H2O2 in HeLa cells, Free Radic. Res. 37 (2003) 1267-1276.
    • (2003) Free Radic. Res. , vol.37 , pp. 1267-1276
    • Kutuk, O.1    Basaga, H.2
  • 17
    • 0025142672 scopus 로고
    • Malondialdehyde determination as index of lipid peroxidation
    • H.H. Draper, M. Hadley, Malondialdehyde determination as index of lipid peroxidation, Meth. Enzymol. 186 (1990) 421-431.
    • (1990) Meth. Enzymol. , vol.186 , pp. 421-431
    • Draper, H.H.1    Hadley, M.2
  • 19
    • 0021318441 scopus 로고
    • Catalase in vitro
    • H. Aebi, Catalase in vitro, Meth. Enzymol. 105 (1984) 121-126.
    • (1984) Meth. Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 21
    • 0031080248 scopus 로고    scopus 로고
    • The role of caspase family of cysteine proteases in apoptosis
    • D.K. Miller, The role of caspase family of cysteine proteases in apoptosis, Semin. Immunol. 9 (1997) 35-49.
    • (1997) Semin. Immunol. , vol.9 , pp. 35-49
    • Miller, D.K.1
  • 23
    • 0034657795 scopus 로고    scopus 로고
    • Anti-inflammatory effect of heat shock protein induction is related to stabilization of IkappaBalpha through preventing IkappaB kinase activation in respiratory epithelial cells
    • C.G. Yoo, S. Lee, C.T. Lee, Y.W. Kim, S.K. Han, Y.S. Shim, Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells, J. Immunol. 164 (2000) 5416-5423. (Pubitemid 30305224)
    • (2000) Journal of Immunology , vol.164 , Issue.10 , pp. 5416-5423
    • Yoo, C.-G.1    Lee, S.2    Lee, C.-T.3    Kim, Y.W.4    Han, S.K.5    Shim, Y.-S.6
  • 24
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-κB in nerve cell survival, plasticity, and disease
    • M.P. Mattson, M.K. Meffert, Roles for NF-κB in nerve cell survival, plasticity, and disease, Cell Death Differ. 13 (2006) 852-860.
    • (2006) Cell Death Differ. , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 25
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
    • DOI 10.1016/S0306-4522(98)00218-8, PII S0306452298002188
    • G.M. Pasinetti, P.S. Aisen, Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain, Neuroscience 87 (1998) 319-324. (Pubitemid 28370892)
    • (1998) Neuroscience , vol.87 , Issue.2 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 26
    • 0032953192 scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, M. Yamamoto, Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain, Genes Dev. 13 (1990) 76-86.
    • (1990) Genes Dev. , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 28
    • 67650508325 scopus 로고    scopus 로고
    • Apoptosis and in vitro Alzheimer disease neuronal models
    • P. Calissano, C. Matrone, G. Amadoro, Apoptosis and in vitro Alzheimer disease neuronal models, Commun. Integr. Biol. 2 (2009) 163-169.
    • (2009) Commun. Integr. Biol. , vol.2 , pp. 163-169
    • Calissano, P.1    Matrone, C.2    Amadoro, G.3
  • 29
    • 77951101600 scopus 로고    scopus 로고
    • A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease
    • P. Taupin, A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease, Cent. Nerv. Syst. Agents Med. Chem. 10 (2010) 16-21.
    • (2010) Cent. Nerv. Syst. Agents Med. Chem. , vol.10 , pp. 16-21
    • Taupin, P.1
  • 30
    • 0002267239 scopus 로고
    • PC12 cells as a model of neuronal differentiation
    • J.E. Bottenstein (Ed.), Plenum Press, New York
    • G. Guroff, PC12 cells as a model of neuronal differentiation. in: J.E. Bottenstein (Ed.), Cell Culture in Neurosciences. Plenum Press, New York, 1985, pp. 245-272.
    • (1985) Cell Culture in Neurosciences , pp. 245-272
    • Guroff, G.1
  • 31
    • 0033955233 scopus 로고    scopus 로고
    • Genes, receptors, signals and responses to lipopolysaccharide endotoxin
    • DOI 10.1046/j.1365-3083.2000.00689.x
    • P.M.C. Wong, S.W. Chung, B.M. Sultzer, Genes, receptors, signals and responses to lipopolysaccharide endotoxin, Scand. J. Immunol. 51 (2000) 123-127. (Pubitemid 30095757)
    • (2000) Scandinavian Journal of Immunology , vol.51 , Issue.2 , pp. 123-127
    • Wong, P.M.C.1    Chung, S.-W.2    Sultzer, B.M.3
  • 32
    • 0036744390 scopus 로고    scopus 로고
    • Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells
    • Y.H. Huang, A.Y. Chang, C.M. Huang, S.W. Huang, S.H. Chan, Proteomic analysis of lipopolysaccharide-induced apoptosis in PC12 cells, Proteomics 2 (2002) 1220-1228.
    • (2002) Proteomics , vol.2 , pp. 1220-1228
    • Huang, Y.H.1    Chang, A.Y.2    Huang, C.M.3    Huang, S.W.4    Chan, S.H.5
  • 33
    • 0027260315 scopus 로고
    • Heat shock protects neuronal cells from programmed cell death by apoptosis
    • DOI 10.1016/0306-4522(93)90428-I
    • C. Mailhos, M.K. Howard, D.S. Latchman, Heat shock protects neuronal cells from programmed cell death by apoptosis, Neuroscience 55 (1993) 621-627. (Pubitemid 23226108)
    • (1993) Neuroscience , vol.55 , Issue.3 , pp. 621-627
    • Mailhos, C.1    Howard, M.K.2    Latchman, D.S.3
  • 34
    • 0026033907 scopus 로고
    • Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells
    • L. Applegate, P. Luscher, R. Tyrrell, Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells, Cancer Res. 51 (1991) 974-978.
    • (1991) Cancer Res. , vol.51 , pp. 974-978
    • Applegate, L.1    Luscher, P.2    Tyrrell, R.3
  • 35
    • 0030583631 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury
    • DOI 10.1016/0006-8993(96)00680-4, PII S0006899396006804
    • K. Fukuda, J.D. Richmon, M. Sato, F.R. Sharp, S.S. Panter, L.J. Noble, Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury, Brain Res. 736 (1996) 68-75. (Pubitemid 26358000)
    • (1996) Brain Research , vol.736 , Issue.1-2 , pp. 68-75
    • Fukuda, K.1    Richmon, J.D.2    Sato, M.3    Sharp, F.R.4    Panter, S.S.5    Noble, L.J.6
  • 36
    • 0348223798 scopus 로고    scopus 로고
    • Many mechanisms for Hsp70 protection from cerebral ischemia
    • R.G. Giffard, M.A. Yenari, Many mechanisms for Hsp70 protection from cerebral ischemia, J. Neurosurg. Anesthesiol. 16 (2004) 53-61.
    • (2004) J. Neurosurg. Anesthesiol. , vol.16 , pp. 53-61
    • Giffard, R.G.1    Yenari, M.A.2
  • 37
    • 37549004821 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke
    • Z. Zheng, J.Y. Kim, H. Ma, J.E. Lee, M.A. Yenari, Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke, J. Cereb. Blood Flow Metab. 28 (2008) 53-63.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 53-63
    • Zheng, Z.1    Kim, J.Y.2    Ma, H.3    Lee, J.E.4    Yenari, M.A.5
  • 38
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • S.C. Sun, S.C. Ley, New insights into NF-kappaB regulation and function, Trends Immunol. 29 (2008) 469-478.
    • (2008) Trends Immunol. , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 39
    • 0037335143 scopus 로고    scopus 로고
    • Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kB pathway
    • DOI 10.1016/S0168-8278(02)00417-8
    • A.K. Kiemerl, T. Hartung, C. Huber, A.M. Vollmar, Phyllanthus amarus has antiinflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kB pathway, J. Hepatol. 38 (2003) 289-297. (Pubitemid 36286541)
    • (2003) Journal of Hepatology , vol.38 , Issue.3 , pp. 289-297
    • Kiemer, A.K.1    Hartung, T.2    Huber, C.3    Vollmar, A.M.4
  • 40
    • 0031826073 scopus 로고    scopus 로고
    • Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex
    • W.J. Lukiw, N.G. Bazan, Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex, J. Neurosci. Res. 53 (1998) 583-592.
    • (1998) J. Neurosci. Res. , vol.53 , pp. 583-592
    • Lukiw, W.J.1    Bazan, N.G.2
  • 41
    • 66349127141 scopus 로고    scopus 로고
    • Cyclooxygenases: Structural and functional insights
    • C.A. Rouzer, L.J. Marnett, Cyclooxygenases: structural and functional insights, J. Lipid Res. 50 (Suppl.) (2009) S29-S34.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Rouzer, C.A.1    Marnett, L.J.2
  • 45
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • DOI 10.1016/j.advenzreg.2006.01.007, PII S0065257106000094, Proceedings of teh 46th International Sumposium on Regulation of the Enzym Activity ans Synthesis in Normal and Neoplastic Tissues
    • M. Kobayashi, M. Yamamoto, Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species, Adv. Enzyme. Regul. 46 (2006) 113-140. (Pubitemid 44301353)
    • (2006) Advances in Enzyme Regulation , vol.46 , Issue.1 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 46
    • 0027319341 scopus 로고
    • Cytotoxicity and genotoxicity of lipidoxidation products
    • H. Esterbauer, Cytotoxicity and genotoxicity of lipidoxidation products, Am. J. Clin. Nutr. Suppl. 57 (1993) 779S-785S.
    • (1993) Am. J. Clin. Nutr. Suppl. , vol.57
    • Esterbauer, H.1
  • 47
    • 0029170274 scopus 로고
    • The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B
    • K.N. Schmidt, P. Amstad, P. Cerutti, P.A. Baeuerle, The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B, Chem. Biol. 2 (1995) 13-22.
    • (1995) Chem. Biol. , vol.2 , pp. 13-22
    • Schmidt, K.N.1    Amstad, P.2    Cerutti, P.3    Baeuerle, P.A.4
  • 48
    • 0037237973 scopus 로고    scopus 로고
    • Antioxidants, oxidative damage and oxygen deprivation stress: A review
    • O. Blokhina, E. Virolainen, K.V. Fagerstedt, Antioxidants, oxidative damage and oxygen deprivation stress: a review, Ann. Bot. 91 (2003) 179-194.
    • (2003) Ann. Bot. , vol.91 , pp. 179-194
    • Blokhina, O.1    Virolainen, E.2    Fagerstedt, K.V.3
  • 49
    • 77949655624 scopus 로고    scopus 로고
    • Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: Involvement of transcription factors Nrf2 and NF-kappaB
    • F. Khodagholi, B. Eftekharzadeh, N. Maghsoudi, P.F. Rezaei, Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB, Mol. Cell Biochem. 337 (2010) 39-51.
    • (2010) Mol. Cell Biochem. , vol.337 , pp. 39-51
    • Khodagholi, F.1    Eftekharzadeh, B.2    Maghsoudi, N.3    Rezaei, P.F.4
  • 50
    • 77953357236 scopus 로고    scopus 로고
    • Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB
    • A.J. Chia, C.E. Goldring, N.R. Kitteringham, S.Q. Wong, P. Morgan, B.K. Park, Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB, Biochem. Pharmacol. 80 (2010) 410-421.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 410-421
    • Chia, A.J.1    Goldring, C.E.2    Kitteringham, N.R.3    Wong, S.Q.4    Morgan, P.5    Park, B.K.6
  • 51
    • 77954621176 scopus 로고    scopus 로고
    • Attenuation of NF-kB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis
    • S.K. Tusi, N. Ansari, M. Amini, A.D. Amirabad, A. Shafiee, F. Khodagholi, Attenuation of NF-kB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis, Apoptosis 15 (2010) 738-751.
    • (2010) Apoptosis , vol.15 , pp. 738-751
    • Tusi, S.K.1    Ansari, N.2    Amini, M.3    Amirabad, A.D.4    Shafiee, A.5    Khodagholi, F.6
  • 52
    • 55949120110 scopus 로고    scopus 로고
    • Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
    • W. Li, T.O. Khor, C. Xu, G. Shen, W.S. Jeong, S. Yu, A.N. Kong, Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis, Biochem. Pharmacol. 76 (2008) 1485-1489.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 1485-1489
    • Li, W.1    Khor, T.O.2    Xu, C.3    Shen, G.4    Jeong, W.S.5    Yu, S.6    Kong, A.N.7


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