An anti-CD33 antibody - Calicheamicin conjugate for treatment of acute myeloid leukemia. Choice of linker

Bioconjugate Chemistry

Volumn 13, Issue 1, 2002, Pages 40-46

  Hamann, Philip R ^a   Hinman, Lois M ^a   Beyer, Carl F ^a   Lindh, Delores ^a   Upeslacis, Janis ^a   Flowers, David A ^b   Bernstein, Irwin ^b  

^a PFIZER INC   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINO ACIDS; ANTIBIOTICS; CARBOHYDRATES; CONTROLLED DRUG DELIVERY; DISEASES; HYDROLYSIS; STEM CELLS; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY; TISSUE CULTURE; TUMORS;

ACTIVE DRUGS; ACUTE MYELOID LEUKEMIA; ANTITUMOR ANTIBIOTICS; CALICHEAMICIN; CELL LINEAGE; CYTOTOXIC; HYDRAZONE BONDS; LYSOZOMES; MYELOID CELLS; PLURIPOTENT STEM CELLS;

ANTIBODIES;

AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC ANTIBIOTIC; CD33 ANTIGEN; DIFFERENTIATION ANTIGEN; IMMUNOTOXIN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ACUTE DISEASE; ANIMAL; ARTICLE; CELL STRAIN HL 60; CHEMISTRY; HUMAN; IMMUNOCHEMISTRY; IMMUNOLOGY; INFRARED SPECTROPHOTOMETRY; MOUSE; MYELOID LEUKEMIA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUDE MOUSE; ULTRAVIOLET SPECTROPHOTOMETRY;

ACUTE DISEASE; AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; HL-60 CELLS; HUMANS; IMMUNOCHEMISTRY; IMMUNOTOXINS; LEUKEMIA, MYELOID; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0036007598     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0100206     Document Type: Article

References (24)

1. I
2. I with glutathione in the presence of double-stranded DNA
3. I
4. Calicheamicins: Discovery, structure, chemistry, and interaction with DNA
5. The development of antibody delivery systems to target cancer with highly potent maytansinoids
6. Enhancement of the selectivity and antitumor activity of a CC-1065 analogue through immunoconjugate formation
7. Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics
8. Preparation of conjugates to monoclonal antibodies
9. Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties
10. Acute leukemia
11. The use of radiolabeled anti-CD33 antibody, to augment marrow irradiation prior to marrow transplantation for acute myelogenous leukemia
12. Localization of radiolabeled antimyeloid antibodies in a human acute leukemia xenograft tumor model
13. Treatment of acute myeloid leukemia cells in vitro with a monoclonal antibody recognizing a myeloid differentiation antigen allows normal progenitor cells to be expressed
14. Biosynthesis of the carbohydrate portion of immunoglobulins
15. Site-specific covalent modification of monoclonal antibodies: In vitro and in vivo evaluations
16. Role of CFTR in lysosomal acidification
17. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
18. Cure of xenografted human carcinoma by Br96-doxorubicin immunoconjugates
19. Elimination of human leukemia by monoclonal antibodies in an athymic nude mouse leukemia model
20. Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells
21. Binding and endocytosis of a monoclonal antibody to a high molecular weight human milk fat globule membrane-associated antigen by cultured MCF-7 breast cancer cells
22. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
23. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: A phase I study of an anti-CD33 calicheamicin immunoconjugate
24. Preliminary results of the efficacy and safety of CMA-676 in Patients with AML in first relapse