-
1
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
10.1038/nm0797-730, 9212098
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997, 3(7):730-7. 10.1038/nm0797-730, 9212098.
-
(1997)
Nat Med
, vol.3
, Issue.7
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
2
-
-
36849083949
-
Cancer stem cell: target for anti-cancer therapy
-
10.1096/fj.07-8560rev, 17625071
-
Tang C, Ang BT, Pervaiz S. Cancer stem cell: target for anti-cancer therapy. FASEB J 2007, 21(14):3777-85. 10.1096/fj.07-8560rev, 17625071.
-
(2007)
FASEB J
, vol.21
, Issue.14
, pp. 3777-3785
-
-
Tang, C.1
Ang, B.T.2
Pervaiz, S.3
-
4
-
-
77949453508
-
Targeted elimination of leukemia stem cells; a new therapeutic approach in hemato-oncology
-
10.2174/138945010790031063, 20017722
-
ten Cate B, et al. Targeted elimination of leukemia stem cells; a new therapeutic approach in hemato-oncology. Curr Drug Targets 2010, 11(1):95-110. 10.2174/138945010790031063, 20017722.
-
(2010)
Curr Drug Targets
, vol.11
, Issue.1
, pp. 95-110
-
-
ten Cate, B.1
-
5
-
-
68749099507
-
A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability
-
10.1038/leu.2009.34, 19262596
-
ten Cate B, et al. A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability. Leukemia 2009, 23(8):1389-97. 10.1038/leu.2009.34, 19262596.
-
(2009)
Leukemia
, vol.23
, Issue.8
, pp. 1389-1397
-
-
ten Cate, B.1
-
6
-
-
33750148809
-
Guidelines on the management of acute myeloid leukaemia in adults
-
10.1111/j.1365-2141.2006.06314.x, 17054678
-
Milligan DW, et al. Guidelines on the management of acute myeloid leukaemia in adults. Br J Haematol 2006, 135(4):450-74. 10.1111/j.1365-2141.2006.06314.x, 17054678.
-
(2006)
Br J Haematol
, vol.135
, Issue.4
, pp. 450-474
-
-
Milligan, D.W.1
-
7
-
-
0031005627
-
Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study
-
Leith CP, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 1997, 89(9):3323-9.
-
(1997)
Blood
, vol.89
, Issue.9
, pp. 3323-3329
-
-
Leith, C.P.1
-
8
-
-
0033151526
-
Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate
-
Sievers EL, et al. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 1999, 93(11):3678-84.
-
(1999)
Blood
, vol.93
, Issue.11
, pp. 3678-3684
-
-
Sievers, E.L.1
-
9
-
-
0035397980
-
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
-
Sievers EL, et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol 2001, 19(13):3244-54.
-
(2001)
J Clin Oncol
, vol.19
, Issue.13
, pp. 3244-3254
-
-
Sievers, E.L.1
-
10
-
-
25144485908
-
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
-
10.1002/cncr.21326, 16116598
-
Larson RA, et al. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer 2005, 104(7):1442-52. 10.1002/cncr.21326, 16116598.
-
(2005)
Cancer
, vol.104
, Issue.7
, pp. 1442-1452
-
-
Larson, R.A.1
-
11
-
-
77950992731
-
Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study
-
10.1182/blood-2009-10-246470, 20103782
-
Lowenberg B, et al. Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study. Blood 2010, 115(13):2586-91. 10.1182/blood-2009-10-246470, 20103782.
-
(2010)
Blood
, vol.115
, Issue.13
, pp. 2586-2591
-
-
Lowenberg, B.1
-
12
-
-
34248338806
-
CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
-
10.1182/blood-2006-09-047399, 1885511, 17227830
-
Walter RB, et al. CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy. Blood 2007, 109(10):4168-70. 10.1182/blood-2006-09-047399, 1885511, 17227830.
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4168-4170
-
-
Walter, R.B.1
-
13
-
-
74249109556
-
Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia
-
10.1038/leu.2009.199, 19776761
-
Jawad M, et al. Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia. Leukemia 2010, 24(1):74-80. 10.1038/leu.2009.199, 19776761.
-
(2010)
Leukemia
, vol.24
, Issue.1
, pp. 74-80
-
-
Jawad, M.1
-
14
-
-
73949131466
-
Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia
-
10.3324/haematol.2009.009811, 2805740, 19648166
-
Zhao X, et al. Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. Haematologica 2010, 95(1):71-8. 10.3324/haematol.2009.009811, 2805740, 19648166.
-
(2010)
Haematologica
, vol.95
, Issue.1
, pp. 71-78
-
-
Zhao, X.1
-
15
-
-
34948839959
-
The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells
-
10.1182/blood-2007-03-083048, 17609428
-
van Rhenen A, et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood 2007, 110(7):2659-66. 10.1182/blood-2007-03-083048, 17609428.
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2659-2666
-
-
van Rhenen, A.1
-
16
-
-
40349095136
-
Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)
-
10.1186/1471-2407-8-51, 2258302, 18271955
-
Tang R, et al. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML). BMC Cancer 2008, 8:51. 10.1186/1471-2407-8-51, 2258302, 18271955.
-
(2008)
BMC Cancer
, vol.8
, pp. 51
-
-
Tang, R.1
-
17
-
-
55949124199
-
Liposomal daunorubicin versus standard daunorubicin: long term follow-up of the GIMEMA GSI 103 AMLE randomized trial in patients older than 60 years with acute myelogenous leukaemia
-
10.1111/j.1365-2141.2008.07400.x, 18950458
-
Latagliata R, et al. Liposomal daunorubicin versus standard daunorubicin: long term follow-up of the GIMEMA GSI 103 AMLE randomized trial in patients older than 60 years with acute myelogenous leukaemia. Br J Haematol 2008, 143(5):681-9. 10.1111/j.1365-2141.2008.07400.x, 18950458.
-
(2008)
Br J Haematol
, vol.143
, Issue.5
, pp. 681-689
-
-
Latagliata, R.1
-
19
-
-
77953043118
-
The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
-
Martelli AM, et al. The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis. Histol Histopathol 2010, 25(5):669-80.
-
(2010)
Histol Histopathol
, vol.25
, Issue.5
, pp. 669-680
-
-
Martelli, A.M.1
-
20
-
-
68849130702
-
Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia
-
10.1517/14728220903136775, 19678801
-
Martelli AM, et al. Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia. Expert Opin Investig Drugs 2009, 18(9):1333-49. 10.1517/14728220903136775, 19678801.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.9
, pp. 1333-1349
-
-
Martelli, A.M.1
-
22
-
-
60849117508
-
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
-
10.1016/j.stem.2009.01.007, 19265662
-
Bleau AM, et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009, 4(3):226-35. 10.1016/j.stem.2009.01.007, 19265662.
-
(2009)
Cell Stem Cell
, vol.4
, Issue.3
, pp. 226-235
-
-
Bleau, A.M.1
-
23
-
-
0029958876
-
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
-
10.1084/jem.183.4.1797, 2192511, 8666936
-
Goodell MA, et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996, 183(4):1797-806. 10.1084/jem.183.4.1797, 2192511, 8666936.
-
(1996)
J Exp Med
, vol.183
, Issue.4
, pp. 1797-1806
-
-
Goodell, M.A.1
-
25
-
-
51849111556
-
PI3K pathway alterations in cancer: variations on a theme
-
10.1038/onc.2008.245, 18794884
-
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008, 27(41):5497-510. 10.1038/onc.2008.245, 18794884.
-
(2008)
Oncogene
, vol.27
, Issue.41
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
26
-
-
77955981973
-
Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors
-
10.1016/j.leukres.2010.01.006, 20193963
-
Muranyi AL, Dedhar S, Hogge DE. Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors. Leuk Res 2010, 34(10):1358-65. 10.1016/j.leukres.2010.01.006, 20193963.
-
(2010)
Leuk Res
, vol.34
, Issue.10
, pp. 1358-1365
-
-
Muranyi, A.L.1
Dedhar, S.2
Hogge, D.E.3
-
27
-
-
77949881462
-
The PI3K pathway as drug target in human cancer
-
10.1200/JCO.2009.25.3641, 2834432, 20085938
-
Courtney KD, Corcoran RB, Engelman JA. The PI3K pathway as drug target in human cancer. J Clin Oncol 2010, 28(6):1075-83. 10.1200/JCO.2009.25.3641, 2834432, 20085938.
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1075-1083
-
-
Courtney, K.D.1
Corcoran, R.B.2
Engelman, J.A.3
-
28
-
-
68949102180
-
Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
-
10.1200/JCO.2008.20.7977, 19581539
-
Hess G, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 2009, 27(23):3822-9. 10.1200/JCO.2008.20.7977, 19581539.
-
(2009)
J Clin Oncol
, vol.27
, Issue.23
, pp. 3822-3829
-
-
Hess, G.1
-
29
-
-
77952301116
-
Phase II Trial of Bevacizumab and Everolimus in Patients With Advanced Renal Cell Carcinoma
-
10.1200/JCO.2009.26.3152, 20368560
-
Hainsworth JD, et al. Phase II Trial of Bevacizumab and Everolimus in Patients With Advanced Renal Cell Carcinoma. J Clin Oncol 2010, 28(13):2131-6. 10.1200/JCO.2009.26.3152, 20368560.
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2131-2136
-
-
Hainsworth, J.D.1
-
30
-
-
77950464935
-
Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia
-
10.1200/JCO.2009.24.0994, 2834498, 20142598
-
Ghobrial IM, et al. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol 2010, 28(8):1408-14. 10.1200/JCO.2009.24.0994, 2834498, 20142598.
-
(2010)
J Clin Oncol
, vol.28
, Issue.8
, pp. 1408-1414
-
-
Ghobrial, I.M.1
-
31
-
-
9244219598
-
Breast cancer--loss of PTEN predicts resistance to treatment
-
10.1056/NEJMcibr043143, 15564551
-
Pandolfi PP. Breast cancer--loss of PTEN predicts resistance to treatment. N Engl J Med 2004, 351(22):2337-8. 10.1056/NEJMcibr043143, 15564551.
-
(2004)
N Engl J Med
, vol.351
, Issue.22
, pp. 2337-2338
-
-
Pandolfi, P.P.1
-
32
-
-
77449117864
-
PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
-
10.1182/blood-2009-06-228130, 2810991, 19965668
-
Peng C, et al. PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood 2010, 115(3):626-35. 10.1182/blood-2009-06-228130, 2810991, 19965668.
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 626-635
-
-
Peng, C.1
-
33
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
10.1056/NEJMoa0905360, 19726763
-
Von Hoff DD, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009, 361(12):1164-72. 10.1056/NEJMoa0905360, 19726763.
-
(2009)
N Engl J Med
, vol.361
, Issue.12
, pp. 1164-1172
-
-
Von Hoff, D.D.1
-
34
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
10.1056/NEJMoa0902903, 19726761
-
Rudin CM, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009, 361(12):1173-8. 10.1056/NEJMoa0902903, 19726761.
-
(2009)
N Engl J Med
, vol.361
, Issue.12
, pp. 1173-1178
-
-
Rudin, C.M.1
-
35
-
-
66049085125
-
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
-
10.1016/j.stem.2009.03.016, 3065323, 19497284
-
Hofmann I, et al. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 2009, 4(6):559-67. 10.1016/j.stem.2009.03.016, 3065323, 19497284.
-
(2009)
Cell Stem Cell
, vol.4
, Issue.6
, pp. 559-567
-
-
Hofmann, I.1
-
36
-
-
64149087422
-
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
-
10.1016/j.addr.2009.02.005, 19249331
-
Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009, 61(4):290-302. 10.1016/j.addr.2009.02.005, 19249331.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, Issue.4
, pp. 290-302
-
-
Fang, J.1
Seki, T.2
Maeda, H.3
-
37
-
-
34547641739
-
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways
-
10.1158/0008-5472.CAN-07-0993, 17671209
-
Kotamraju S, Williams CL, Kalyanaraman B. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer Res 2007, 67(15):7386-94. 10.1158/0008-5472.CAN-07-0993, 17671209.
-
(2007)
Cancer Res
, vol.67
, Issue.15
, pp. 7386-7394
-
-
Kotamraju, S.1
Williams, C.L.2
Kalyanaraman, B.3
-
38
-
-
79960292392
-
Combination of simvastatin and imatinib sensitizes the CD34+ cells in K562 to cell death
-
Chen R, et al. Combination of simvastatin and imatinib sensitizes the CD34+ cells in K562 to cell death. Med Oncol 2010,
-
(2010)
Med Oncol
-
-
Chen, R.1
-
39
-
-
77950160186
-
P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells
-
10.1021/nn9011225, 20148593
-
Li R, et al. P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells. ACS Nano 2010, 4(3):1399-408. 10.1021/nn9011225, 20148593.
-
(2010)
ACS Nano
, vol.4
, Issue.3
, pp. 1399-1408
-
-
Li, R.1
-
40
-
-
70349326661
-
Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia
-
10.1016/j.biopha.2008.10.008, 19095404
-
Li GY, et al. Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia. Biomed Pharmacother 2009, 63(8):566-70. 10.1016/j.biopha.2008.10.008, 19095404.
-
(2009)
Biomed Pharmacother
, vol.63
, Issue.8
, pp. 566-570
-
-
Li, G.Y.1
-
41
-
-
77957375466
-
Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma
-
10.1371/journal.pone.0009750, 2841188, 20305783
-
Balyasnikova IV, et al. Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma. PLoS One 2010, 5(3):e9750. 10.1371/journal.pone.0009750, 2841188, 20305783.
-
(2010)
PLoS One
, vol.5
, Issue.3
-
-
Balyasnikova, I.V.1
-
42
-
-
72849137758
-
Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells
-
10.1186/1756-9966-28-141, 2779804, 19883517
-
Wei Z, et al. Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells. J Exp Clin Cancer Res 2009, 28:141. 10.1186/1756-9966-28-141, 2779804, 19883517.
-
(2009)
J Exp Clin Cancer Res
, vol.28
, pp. 141
-
-
Wei, Z.1
-
43
-
-
0035878746
-
Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor
-
Mishima K, et al. Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. Cancer Res 2001, 61(14):5349-54.
-
(2001)
Cancer Res
, vol.61
, Issue.14
, pp. 5349-5354
-
-
Mishima, K.1
-
44
-
-
78349234668
-
Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis
-
2958340, 20981352
-
Morrison R, et al. Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis. J Oncol 2011, 2011:941876. 2958340, 20981352.
-
(2011)
J Oncol
, vol.2011
, pp. 941876
-
-
Morrison, R.1
|