Hierarchical organization of prostate cancer cells in xenograft tumors: The CD44+α2β1+ cell population is enriched in tumor-initiating cells

Cancer Research

Volumn 67, Issue 14, 2007, Pages 6796-6805

  Patrawala, Lubna ^a   Calhoun Davis, Tammy ^a   Schneider Broussard, Robin ^a   Tang, Dean G ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; VERY LATE ACTIVATION ANTIGEN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL ISOLATION; CELL POPULATION; CLONING; CLONOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; PURIFICATION; SCID MOUSE; STEM CELL; XENOGRAFT;

ANIMALS; ANTIGENS, CD44; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHA2BETA1; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; PROSTATIC NEOPLASMS;

EID: 34547128128     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0490     Document Type: Article

References (33)

1. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
2. Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
3. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
4. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100:3983-8.
5. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumor initiating cells. Nature 2004;432:396-401.
6. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10.
7. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445:111-5.
8. Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells - perspectives on current status and future directions: AACR work shop on cancer stem cells. Cancer Res 2006;66:9339-44.
9. Tang DG, Patrawala L, Calhoun T, et al. Prostate cancer stem/progenitor cells: identification, characterization, and implications. Mol Carcinog 2007;46:1-14.
10. Reiter RE, Sawyers CL. Xenograft models and the molecular biology of human prostate cancer. In: Chung LWK, Isaacs WB, Simons JW, editors. Prostate cancer: biology, genetics, and the new therapeutics. Totowa (NJ): Humana Press Inc.; 2001. p. 163-74.
11. Bhatia B, Tang S, Yang P, et al. Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells. Oncogene 2005;24:3583-95.
12. Liu AY, True LD, LaTray L, et al. Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci USA 1997;94:10705-10.
13. McDonnell TJ, Troncoso P, Brisbay SM, et al. Expression of the proto-oncogene bcl-2 in the prostate and its association with emergence of androgenin-dependent prostate cancer. Cancer Res 1992;52:6940-4.
14. Signoretti S, Waltregny D, Dilks J, et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000;157:1769-75.
15. Myers RB, Grizzle WE. Changes in biomarker expression in the development of prostatic adenocarcinoma. Biotech Histochem 1997;72:86-95.
16. Bui M, Reiter RE. Stem cell genes in androgen-independent prostate cancer. Cancer Mestastasis Rev 1999;17:391-9.
17. Cookson MS, Reuter VE, Linkov I, Fair WR. Glutathione S-transferase (GST-π) class expression by immunohistochemistry in benign and malignant prostate tissue. J Urol 1997;157:673-6.
18. Bonkhoff H, Stein U, Remberger K. The proliferative function of basal cells in the normal and hyperplastic human prostate. Prostate 1994;24:42-6.
19. Hayward SW, Haughney PC, Rosen MA, et al. Interactions between adult human prostate epithelium and rat urogenital sinus mesenchyme in a tissue recombination model. Differentiation 1998;63:131-40.
20. Collins AT, Habib FK, Maitland NJ, Neal DE. Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression. J Cell Sci 2001;114:3865-72.
21. Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT. CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci 2004;117:3539-45.
22. Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005;65:10946-51.
23. - cancer cells are similarly tumorigenic. Cancer Res 2005;65:6207-19.
24. + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 2006;25:1696-708.
25. Knox JD, Cress AE, Clark V, et al. Differential expression of extracellular matrix molecules and the a 6-integrins in the normal and neoplastic prostate. Am J Pathol 1994;145:167-74.
26. Janes SM, Watt FM. New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer 2006;6:175-83.
27. van Bokhoven A, Varella-Garcia M, Korch C, et al. Molecular characterization of human prostate carcinoma cell lines. Prostate 2003;57:205-25.
28. Wang SY, Revelo MP, Sudilovsky D, et al. Development and characterization of efficient xenograft models for benign and malignant human prostate. Prostate 2005;64:149-59.
29. Hope KJ, Jin L, Dick JE. Acute myeoloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004;5:738-43.
30. Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 2007;104:973-8.
31. Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007;67:1030-7.
32. Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 2006;12:1175-80.
33. Jin L, Hope KJ, Zhai Q, Smadjia-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006;12:1167-74.