Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

Neurochemistry International

Volumn 62, Issue 4, 2013, Pages 468-477

  Hu, Shengquan ^a   Cui, Wei ^a   Mak, Shinghung ^a   Tang, Jing ^b   Choi, Chunglit ^a   Pang, Yuanping ^b   Han, Yifan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b MAYO CLINIC CANCER CENTER   (United States)

Author keywords

Bis(propyl) cognitin; Cerebellar granule neuron; Extracellular signal regulated kinase; Neuroprotection; Nitric oxide; Phosphoinositide 3 kinase

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; BIS(PROPYL)COGNITIN; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; LACTATE DEHYDROGENASE; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N(G) METHYLARGININE; NEUROPROTECTIVE AGENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL VIABILITY; CEREBELLAR GRANULE NEURON; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; EXCITOTOXICITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; MAP KINASE SIGNALING SYSTEM; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; TACRINE;

RATTUS;

EID: 84874595915     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.01.022     Document Type: Article

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