PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK

Neuroscience Letters

Volumn 422, Issue 1, 2007, Pages 64-67

  Chen, Ren Wu ^a   Lu, X C May ^a   Yao, Changping ^a   Liao, Zhilin ^a   Jiang, Zhi Gang ^b   Wei, Hans ^a   Ghanbari, Hossein A ^b   Tortella, Frank C ^a   Dave, Jitendra R ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Panacea Pharmaceuticals Inc   (United States)

Author keywords

Bcl 2; c Jun N terminal kinase; Glutamate toxicity; Mitogen activated protein kinase; Neuroprotection; PAN 811

Indexed keywords

3 AMINOPICOLINALDEHYDE THIOSEMICARBAZONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLUTAMIC ACID; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BRAIN HYPOXIA; BRAIN INFARCTION; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ANIMALS; ANTHRACENES; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GENES, BCL-2; GLUTAMIC ACID; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PREGNANCY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS; THIAZOLES; THIOSEMICARBAZONES;

EID: 34447550144     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.06.004     Document Type: Article

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