The pharmacological manipulation of glutamate receptors and neuroprotection

European Journal of Pharmacology

Volumn 447, Issue 2-3, 2002, Pages 285-296

  Stone, Trevor W ^a   Addae, Jonas ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

Glutamate; Kynurenic acid; Kynurenine; Neurodegeneration; Neuroprotection; Quinolinic acid

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3,4 DICHLOROBENZOYLALANINE; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ALANINE DERIVATIVE; AMPA RECEPTOR; CALCIUM BINDING PROTEIN; CALCIUM ION; DIZOCILPINE; EXCITOTOXIN; FCE 28833A; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE; KYNURENIC ACID; KYNURENIC ACID DERIVATIVE; KYNURENINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NICOTINYLALANINE; POLYAMINE; PURINE; QUINOLINIC ACID; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; CELL DAMAGE; CELL DEATH; CLINICAL TRIAL; DEMENTIA; DESENSITIZATION; HEART INFARCTION PREVENTION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; METABOLISM; NERVE CELL LESION; NERVE CELL PLASTICITY; NEUROPROTECTION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BLOCKING; RECEPTOR SENSITIVITY; REVIEW;

EID: 0037025273     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01851-4     Document Type: Article

References (166)

1. Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex
2. NMDA-induced changes in a cortical network in vivo are prevented by AMPA
3. Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury
4. Oxygen-free radicals regulate NMDA receptor function via a redox modulatory site
5. Is the AMPA receptor subunit GluR2 mRNA an early indicator of cell fate after ischemia? A quantitative single cell RT-PCR study
6. 2+]i changes in cultured rat hippocampal neurons
7. Metabotropic glutamate receptors
8. The role of divalent cations in the NMDA responses of mouse central neurones in culture
9. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
10. Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord
11. Interactions of adenosine and magnesium on rat hippocampal slices
12. Activation of NMDA receptor-coupled channels suppresses the inhibitory action of adenosine on hippocampal slices
13. Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death
14. Role of kynurenine in the neurotoxic actions of kainic acid
15. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl
16. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus
17. Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop
18. Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor
19. Molecular structure of glutamate receptor channels
20. Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel
21. NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus
22. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: Investigations into possible mechanism of action in vivo
23. Activity-dependent modulation of glutamate receptors by polyamines
24. Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist
25. Induction of tolerance in rat cortical neurons: Hypoxic preconditioning
26. Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta
27. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors
28. Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death
29. 2+-dependent desensitization of AMPA receptors
30. 2+-permeable AMPA-kainate receptors in fusiform cerebellar glial cells
31. Ifenprodil and SL82.0715 are antagonists at the polyamine site of the NMDA receptor
32. Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors
33. Regulation of AMPA receptors by phosphorylation
34. Inhibition of dendritic calcium influx by activation of G-protein-coupled receptors in the hippocampus
35. Ischemic tolerance in the brain
36. Metabotropic glutamate receptor-mediated control of neurotransmitter release
37. Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: Role of calcium channels
38. Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity
39. 2+ signaling in CA1 neurons after brief ischemia in gerbils
40. 3H]-noradrenaline from hippocampal slices
41. Endogenous sulphur-containing amino acids: Potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system
42. NMDA receptor subunits: Diversity, development and disease
43. Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27
44. 2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
45. Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation
46. 2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors
47. 3H]norepinephrine release in rat hippocampal slices
48. The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine
49. Activated human microglia produce the excitotoxin quinolinic acid
50. Involvement of divalent ions in the nitric oxide-induced blockade of N-methyl-D-aspartate receptors in cerebellar granule cells
51. Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
52. Unchanged balance between levels of mRNA encoding AMPA glutamate receptor subtypes following global cerebral ischemia in the rat
53. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
54. Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro
55. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
56. Caspase-mediated degradation of AMPA receptor subunits: A mechanism for preventing excitotoxic necrosis and ensuring apoptosis
57. 2+) uptake by rat brain synaptosomes
58. 2+) uptake by electrically stimulated rat brain synaptosomes
59. Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons
60. Ischemic tolerance in murine cortical cell culture: Critical role for NMDA receptors
61. 2+-permeable AMPA receptors
62. Subtypes of glutamate receptors: Pharmacological classification
63. Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid
64. 2+)-binding proteins in human neurodegenerative disorders
65. Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected Rhesus macaques: Relationship to clinical and viral status
66. Human microglia convert L-tryptophan into the neurotoxin quinolinic acid
67. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition
68. N-Glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
69. 2+)-permeable AMPA receptors by Joro spider toxin in cultured rat hippocampal neurones
70. 2+-permeable AMPA-type glutamate receptor channels in rat neocortical neurons
71. Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells
72. Glycine potentiates the NMDA response in cultured mouse brain neurones
73. 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression
74. Protection against hippocampal kainate excitotoxicity by intracerebral administration of an adenosine A2A receptor antagonist
75. Protection against kainate-induced excitotoxicity by adenosine A2A receptor agonists and antagonists
76. Protection against post-ischemic behavioral pathology by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil
77. Differential modulation of the GYKI 53784-induced inhibition of AMPA currents by various AMPA-positive modulators in cerebellar Purkinje cells
78. The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys
79. Quinolinic acid metabolism in the rat brain: Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region
80. 2+-binding proteins in rat forebrain neurons
81. Synaptic and non-synaptic AMPA receptors permeable to calcium. Japan
82. 2+ entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons
83. MGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons
84. Cerestat and other NMDA antagonists in ischemic stroke
85. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
86. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
87. Neuronal injury associated with HIV-1: Approaches to treatment
88. 2+-permeable AMPA receptors induces a switch in receptor subtype
89. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
90. Group I metabotropic glutamate antagonist reduces acute neuronal degeneration and behavioral deficits after traumatic brain injury in rats
91. 6 phenylisopropyladenosine, of kainic acid neurotoxicity in rat hippocampus after systemic administration
92. Mediation of the neuroprotective action of R-phenylisopropyladenosine through a centrally located adenosine A1 receptor
93. Cyclothiazide treatment unmasks AMPA excitotoxicity in rat primary hippocampal cultures
94. 2+/calmodulin dependent protein kinase II
95. 2+ in hippocampal neurons
96. Novel AMPA receptor potentiators LY392098 and LY404187: Effects on recombinant human AMPA receptors in vitro
97. 2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
98. Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: Results of two phase III clinical trials
99. A molecular determinant for submillisecond desensitization in glutamate receptors
100. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546
101. Synthesis and activity of enantiopure (S) (m-nitrobenzoyl) alanine, potent kynurenine-3-hydroxylase inhibitor
102. Suppression of presynaptic responses to adenosine by activation of NMDA receptors
103. Effect of adenosine and some of its structural analogues on the conductance of NMDA receptor channels in a subset of rat neostriatal neurones
104. Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy
105. 2+ after exposure to glutamate receptor agonist
106. 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: Structure-activity relationships for the AMPA-type non-NMDA receptor
107. 2A receptors and neuroprotection
108. Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines
109. High affinity zinc inhibition of NMDA NR1-NR2A receptors
110. Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants
111. AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate
112. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats
113. 2+)-permeable AMPA receptors in neurological disorders
114. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: Time-course and mechanisms
115. Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl) alanine, a potent inhibitor of kynurenine-3-hydroxylase
116. 2+ and increase excitability promote tolerance against anoxia in hippocampal slices
117. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
118. Phosphonate analogues of carboxylic acids as amino acid antagonists on rat cortical neurons
119. 2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons
120. The metabotropic glutamate receptors: Structure and function
121. Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat
122. 2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons
123. Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line
124. Modulation of glutamate receptor function by polyamines
125. 2+-dependent inactivation of synaptic NMDA receptors in hippocampal neurons
126. The tetrameric structure of a glutamate receptor channel
127. Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions
128. Enhancement of heat shock protein expression after transient ischemia in the preconditioned spinal cord of rabbits
129. Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones
130. Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors
131. Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release
132. A novel allosteric potentiator of AMPA receptors: 4-2-(phenylsulfonylamino)ethylthio-2,6-difluoro-phenoxyacetamide
133. Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance
134. 2A receptor agonist CGS21680
135. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia
136. Differential localisation of metabotropic glutamate receptor subtypes in the rat hippocampus
137. MGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C
138. 2+-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity
139. Flip and flop: A cell-specific functional switch in glutamate-operated channels of the CNS
140. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
141. Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus
142. (R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats
143. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors
144. Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices
145. Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate
146. Neuropharmacology of quinolinic and kynurenic acids
147. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection
148. Kynurenines in the CNS: From obscurity to therapeutic importance
149. Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
150. Neuroprotection by A2A receptor antagonists
151. 2+/calmodulin-dependent protein kinase II and protein kinase C in cultured hippocampal neurons
152. Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals
153. Cyclohexyl adenosine protects against neuronal death following ischaemia in the CA1 region of gerbil hippocampus
154. Protective effect of cyclohexyladenosine in treatment of cerebral ischaemia in gerbils
155. In vivo models of cerebral ischaemia: Effects of parenterally administered NMDA receptor glycine site antagonists
156. Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins
157. Interactions of the dye Evans Blue and GYKI 52466, a 2,3-benzodiazepine, with (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured rat cortical neurons: Electrophysiological evidence for at least two different binding sites for non-competitive antagonists
158. Ifenprodil discriminates subtypes of the NMDA receptor. Selectivity and mechanisms at recombinant heteromeric receptors
159. Subunit- and site-specific pharmacology of the NMDA receptor channel
160. Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
161. Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death
162. Interactions of glutamate receptor agonists with long-term potentiation in the rat hippocampal slice
163. Long-term potentiation protects rat hippocampal slices from the effects of acute hypoxia
164. 2+-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation
165. The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury