The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

Neuroscience Letters

Volumn 306, Issue 1-2, 2001, Pages 81-84

  Rammes, G ^a   Rupprecht, R ^a   Ferrari, U ^a   Zieglgansberger W ^a   Parsons, C G ^b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

5 HT3 receptor; Ionotropic; Memantine; Patch clamp; Recombinant; Serotonin

Indexed keywords

AMANTADINE; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NERAMEXANE; SEROTONIN 3 RECEPTOR;

ANIMAL CELL; ARTICLE; CELL LINE; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; KIDNEY CELL; MEMBRANE CURRENT; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING, COMPETITIVE; CELL MEMBRANE; CELLS, CULTURED; CYCLOHEXANES; CYCLOPENTANES; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; MEMANTINE; MEMBRANE POTENTIALS; MICE; NEUROPROTECTIVE AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS;

EID: 0035933672     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01872-9     Document Type: Article

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