메뉴 건너뛰기




Volumn 18, Issue 9, 2004, Pages 575-583

What are the treatment options for patients with severe Alzheimer's disease?

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; GLUTAMIC ACID; MEMANTINE; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENANTHRENE; PIPERIDINE; RIVASTIGMINE; TACRINE;

EID: 3242669518     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200418090-00003     Document Type: Review
Times cited : (24)

References (34)
  • 1
    • 0028558995 scopus 로고
    • Patterns of caring for people with dementia in Canada
    • Canadian Study of Health and Aging Working Group. Patterns of caring for people with dementia in Canada. Can J Aging 1994; 13: 470-87
    • (1994) Can J Aging , vol.13 , pp. 470-487
  • 2
    • 0036047651 scopus 로고    scopus 로고
    • Measuring cognition in advanced Alzheimer's disease for clinical trials
    • Schmitt FA, Cragar D, Ashford JW, et al. Measuring cognition in advanced Alzheimer's disease for clinical trials. J Neural Transm 2002; 62: S135-48
    • (2002) J Neural Transm , vol.62
    • Schmitt, F.A.1    Cragar, D.2    Ashford, J.W.3
  • 3
    • 0035964226 scopus 로고    scopus 로고
    • Donepezil MSAD Study Investigators Group. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease
    • Feldman H, Gauthier S, Hecker J, et al. Donepezil MSAD Study Investigators Group. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 2001; 57: 613-20
    • (2001) Neurology , vol.57 , pp. 613-620
    • Feldman, H.1    Gauthier, S.2    Hecker, J.3
  • 4
    • 0034877979 scopus 로고    scopus 로고
    • Pharmacotherapy of Alzheimer's disease: Is these a need to redefine treatment success?
    • Winblad B, Brodaty H, Gauthier S, et al. Pharmacotherapy of Alzheimer's disease: is these a need to redefine treatment success? Int J Geriatr Psychiatry 2001; 16 (7): 653-66
    • (2001) Int J Geriatr Psychiatry , vol.16 , Issue.7 , pp. 653-666
    • Winblad, B.1    Brodaty, H.2    Gauthier, S.3
  • 5
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
    • Feb
    • Winblad B, Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry 1999 Feb; 14 (2): 135-46
    • (1999) Int J Geriatr Psychiatry , vol.14 , Issue.2 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 6
    • 0033591017 scopus 로고    scopus 로고
    • Cholinergic markers in elderly patients with early signs of Alzheimer disease
    • Davis KL, Mohs RC, Marin D, et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 1999; 281: 1401-6
    • (1999) JAMA , vol.281 , pp. 1401-1406
    • Davis, K.L.1    Mohs, R.C.2    Marin, D.3
  • 7
    • 0141818331 scopus 로고    scopus 로고
    • Have cholinergic therapies reached their clinical boundary in Alzheimer's disease?
    • Jones RW. Have cholinergic therapies reached their clinical boundary in Alzheimer's disease? Int J Geriatr Psychiatry 2003; 18: S7-S13
    • (2003) Int J Geriatr Psychiatry , vol.18
    • Jones, R.W.1
  • 8
    • 0141818332 scopus 로고    scopus 로고
    • Cholinergic function and Alzheimer's disease
    • Giacobini E. Cholinergic function and Alzheimer's disease. Int J Geriatr Psychiatry 2003; 18 (Suppl.): S1-5
    • (2003) Int J Geriatr Psychiatry , vol.18 , Issue.SUPPL.
    • Giacobini, E.1
  • 9
    • 0032709113 scopus 로고    scopus 로고
    • The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease
    • Mega MS, Masterman DM, O'Connor SM, et al. The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease. Arch Neurol 1999; 56: 1388-93
    • (1999) Arch Neurol , vol.56 , pp. 1388-1393
    • Mega, M.S.1    Masterman, D.M.2    O'Connor, S.M.3
  • 10
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • Dekosky ST, Ikonomovic MD, Styren SD, et al. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002; 51 (2): 145-55
    • (2002) Ann Neurol , vol.51 , Issue.2 , pp. 145-155
    • Dekosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3
  • 11
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
    • Rogers SL, Farlow MR, Doody RS, et al. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Neurology 1998; 50: 136-45
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3
  • 12
    • 0031902795 scopus 로고    scopus 로고
    • A randomised trial evaluating the efficacy and safety of rivastigmine tartrate, a new acetylcholinesterase inhibitor in patients with mild to moderately severe Alzheimer's disease
    • Corey-Bloom J, Anand R, Veach J. A randomised trial evaluating the efficacy and safety of rivastigmine tartrate, a new acetylcholinesterase inhibitor in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol 1998; 1: 55-65
    • (1998) Int J Geriatr Psychopharmacol , vol.1 , pp. 55-65
    • Corey-Bloom, J.1    Anand, R.2    Veach, J.3
  • 13
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized, placebo-controlled trial of galantamine in AD
    • The Galantamine US A-10 Study Group
    • Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine US A-10 Study Group. Neurology 2000; 54: 2269-76
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3
  • 14
    • 0034467344 scopus 로고    scopus 로고
    • Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
    • Ogura H, Kosasa T, Kuriya Y, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol 2000; 22: 609-13
    • (2000) Methods Find Exp Clin Pharmacol , vol.22 , pp. 609-613
    • Ogura, H.1    Kosasa, T.2    Kuriya, Y.3
  • 15
    • 0032926540 scopus 로고    scopus 로고
    • The effects of donepezil in Alzheimer's disease: Results from a multinational trial
    • Burns A, Rossor M, Hecker J, et al. The effects of donepezil in Alzheimer's disease: results from a multinational trial. Dement Geriatr Cogn Disord 1999; 10: 237-44
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 237-244
    • Burns, A.1    Rossor, M.2    Hecker, J.3
  • 16
    • 3242724486 scopus 로고    scopus 로고
    • The relationship between donepezil and behavioral disturbance in patients with Alzheimer's disease
    • Cummings JL, Donohue JA, Brooks RL. The relationship between donepezil and behavioral disturbance in patients with Alzheimer's disease. Am J Geriatr Psychiatry 2000; 97 (11): 6037-42
    • (2000) Am J Geriatr Psychiatry , vol.97 , Issue.11 , pp. 6037-6042
    • Cummings, J.L.1    Donohue, J.A.2    Brooks, R.L.3
  • 17
    • 0035859879 scopus 로고    scopus 로고
    • A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
    • Winblad B, Engedal K, Soininen H, et al. A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Neurology 2001; 57: 489-95
    • (2001) Neurology , vol.57 , pp. 489-495
    • Winblad, B.1    Engedal, K.2    Soininen, H.3
  • 18
    • 0031718551 scopus 로고    scopus 로고
    • Clinical pharmacology of rivastigmine: A new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • Polinsky RJ. Clinical pharmacology of rivastigmine: a new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther 1998; 20 (4): 634-47
    • (1998) Clin Ther , vol.20 , Issue.4 , pp. 634-647
    • Polinsky, R.J.1
  • 19
    • 0033528436 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial
    • Rösler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. BMJ 1999; 318: 633-8
    • (1999) BMJ , vol.318 , pp. 633-638
    • Rösler, M.1    Anand, R.2    Cicin-Sain, A.3
  • 20
    • 0001343442 scopus 로고    scopus 로고
    • Rivastigmine provides behavioral benefits to AD patients residing in a nursing home: Findings from a 26-week trial
    • Cummings J, Anand R, Koumaras B, et al. Rivastigmine provides behavioral benefits to AD patients residing in a nursing home: findings from a 26-week trial [abstract]. Neurology 2000; 54: A468
    • (2000) Neurology , vol.54
    • Cummings, J.1    Anand, R.2    Koumaras, B.3
  • 21
    • 0005997029 scopus 로고    scopus 로고
    • Effects of rivastigmine on behavioural symptoms in nursing home patients with Alzheimer's disease: A European, open-label, multicentre study
    • Bullock R, Moulias R, Steinwachs K-C, et al. Effects of rivastigmine on behavioural symptoms in nursing home patients with Alzheimer's disease: a European, open-label, multicentre study [abstract]. Int Psychogeriatr 2001; 13 Suppl. 2: P-248
    • (2001) Int Psychogeriatr , vol.13 , Issue.2 SUPPL.
    • Bullock, R.1    Moulias, R.2    Steinwachs, K.-C.3
  • 22
    • 0034676757 scopus 로고    scopus 로고
    • Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study
    • McKeith I, Del Ser T, Spano P, et al. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 2000; 356: 2031-6
    • (2000) Lancet , vol.356 , pp. 2031-2036
    • McKeith, I.1    Del Ser, T.2    Spano, P.3
  • 23
    • 0000174434 scopus 로고    scopus 로고
    • Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in CSF of mild AD patients following 12 months of rivastigmine treatment
    • Nordberg A, Darreh-Shori T, Svensson A, et al. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in CSF of mild AD patients following 12 months of rivastigmine treatment [abstract]. J Neurol Sci 2001; 187 Suppl. 1: P0144
    • (2001) J Neurol Sci , vol.187 , Issue.1 SUPPL.
    • Nordberg, A.1    Darreh-Shori, T.2    Svensson, A.3
  • 24
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized, placebo-controlled trial of galantaminein AD
    • Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantaminein AD. Neurology 2000; 54: 2269-76
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3
  • 25
    • 0034627263 scopus 로고    scopus 로고
    • Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: Multicentre randomized controlled trial Galantamine International-1 study group
    • Dec 9
    • Wilcock GK, Lilienfeld S, Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomized controlled trial Galantamine International-1 study group. BMI 2000 Dec 9; 321: 1445-9
    • (2000) BMI , vol.321 , pp. 1445-1449
    • Wilcock, G.K.1    Lilienfeld, S.2    Gaens, E.3
  • 26
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension
    • The Galantamine USA-1 Study Group
    • Raskind MA, Peskind ER, Wessel T, et al. Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 2000; 54 (12): 2261-8
    • (2000) Neurology , vol.54 , Issue.12 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3
  • 27
    • 0038315311 scopus 로고    scopus 로고
    • Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden
    • Feldman H, Gauthier S, Hecker I, et al. Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden. J Am Geriatr Soc 2003; 51: 737-44
    • (2003) J Am Geriatr Soc , vol.51 , pp. 737-744
    • Feldman, H.1    Gauthier, S.2    Hecker, I.3
  • 28
    • 0035661596 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting
    • Dec
    • Tariot PN, Cummings IL, Katz IR, et al. A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting. J Am Geriatr Soc 2001 Dec; 49 (12): 1590-9
    • (2001) J Am Geriatr Soc , vol.49 , Issue.12 , pp. 1590-1599
    • Tariot, P.N.1    Cummings, I.L.2    Katz, I.R.3
  • 29
    • 0037236816 scopus 로고    scopus 로고
    • Galantamine provides sustained benefits in patients with 'advanced moderate' Alzheimer's disease for at least 12 months
    • Blesa R, Davidson M, Kurz A, et al. Galantamine provides sustained benefits in patients with 'advanced moderate' Alzheimer's disease for at least 12 months. Dement Geriatr Cogn Disord 2003; 15 (2): 79-87
    • (2003) Dement Geriatr Cogn Disord , vol.15 , Issue.2 , pp. 79-87
    • Blesa, R.1    Davidson, M.2    Kurz, A.3
  • 30
    • 0036016290 scopus 로고    scopus 로고
    • Long-term effects of rivastigmine in moderately severe Alzheimer's disease: Does early initiation of therapy offer sustained benefits?
    • May
    • Doraiswamy PM, Krishnan KR, Anand R, et al. Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits? Prog Neuropsychopharmacol Biol Psychiatry 2002 May; 26 (4): 705-12
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , Issue.4 , pp. 705-712
    • Doraiswamy, P.M.1    Krishnan, K.R.2    Anand, R.3
  • 31
    • 0037417238 scopus 로고    scopus 로고
    • A randomized placebo-controlled study of memantine, an uncompetitive NMDA antagonist, in patients with moderate to severe Alzheimer's disease
    • Reisberg B, Doody R, Stoffler A, et al. A randomized placebo-controlled study of memantine, an uncompetitive NMDA antagonist, in patients with moderate to severe Alzheimer's disease. N Engl J Med 2003; 348: 1333-41
    • (2003) N Engl J Med , vol.348 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stoffler, A.3
  • 32
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Jan 21
    • Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 2004 Jan 21; 291 (3): 317-24
    • (2004) JAMA , vol.291 , Issue.3 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3
  • 33
    • 0141594927 scopus 로고    scopus 로고
    • Realistic expectations: The management of severe Alzheimer disease
    • Jul-Sep
    • Bullock R, Hammond G. Realistic expectations: the management of severe Alzheimer disease. Alzheimer Dis Assoc Disord 2003 Jul-Sep; 17 Suppl 3: S80-5
    • (2003) Alzheimer Dis Assoc Disord , vol.17 , Issue.3 SUPPL.
    • Bullock, R.1    Hammond, G.2
  • 34
    • 0037272817 scopus 로고    scopus 로고
    • The REAL.FR Research program on Alzheimer's Disease and its management: Methods and preliminary results
    • Gillette S, Nourhashemi F, Andrieu S, et al. The REAL.FR Research program on Alzheimer's Disease and its management: methods and preliminary results. J Nutr Health Aging 2003; 2: 91-6
    • (2003) J Nutr Health Aging , vol.2 , pp. 91-96
    • Gillette, S.1    Nourhashemi, F.2    Andrieu, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.