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Volumn 10, Issue 25, 2004, Pages 3177-3184

New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease

Author keywords

ACh; AChE BuChE inhibitors; AD; Amyloid ; Galanthamine; nAChR; Neurodegenerative diseases; Rivastigmine; Tacrine

Indexed keywords

ALPHA TOCOPHEROL; ALZHEIMER DISEASE VACCINE; AMINO ACID DERIVATIVE; AMIRIDINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CHELATING AGENT; CHOLINERGIC RECEPTOR; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CITICOLINE; DONEPEZIL; ESTRADIOL; ESTROGEN; GALANTAMINE; GAMMA SECRETASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; MELATONIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NICOTINIC RECEPTOR; NIMODIPINE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BCL 2; RIVASTIGMINE; ROFECOXIB; TACRINE; TACRINE DERIVATIVE; UNINDEXED DRUG;

EID: 4544247386     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043383368     Document Type: Review
Times cited : (41)

References (91)
  • 1
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999; 399: A23-A31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 4
    • 0033846277 scopus 로고    scopus 로고
    • Central nicotinic receptors, neurotrophic factor and neuroprotection
    • Belluardo N, Mudo G, Blum, M, Fuxe K. Central nicotinic receptors, neurotrophic factor and neuroprotection. Behav Brain Res 2000; 113: 21-34.
    • (2000) Behav. Brain Res. , vol.113 , pp. 21-34
    • Belluardo, N.1    Mudo, G.2    Blum, M.3    Fuxe, K.4
  • 5
    • 0029899143 scopus 로고    scopus 로고
    • In vitro neuroprotective properties of the novel cholinergic channels activator (ChCA), ABT-418
    • Donnely-Roberts DL, Xue IC, Arneric SP, Sullivan JP. In vitro neuroprotective properties of the novel cholinergic channels activator (ChCA), ABT-418. Brain Res 1996; 719: 36-44.
    • (1996) Brain Res. , vol.719 , pp. 36-44
    • Donnely-Roberts, D.L.1    Xue, I.C.2    Arneric, S.P.3    Sullivan, J.P.4
  • 6
    • 0030564986 scopus 로고    scopus 로고
    • Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation
    • Yamashita H, Nakamura S. Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation. Neurosci Lett 1996; 213: 145-147.
    • (1996) Neurosci. Lett. , vol.213 , pp. 145-147
    • Yamashita, H.1    Nakamura, S.2
  • 7
    • 0031975130 scopus 로고    scopus 로고
    • Nicotinic α 7 receptors protect against glutamate neurotoxicity and neuronal ischaemic damage
    • Shimohama S, Greenwald DL, Shafron DH, Akaika A, Maeda T, et al. Nicotinic α 7 receptors protect against glutamate neurotoxicity and neuronal ischaemic damage. Brain Res 1998; 779: 359-363.
    • (1998) Brain Res. , vol.779 , pp. 359-363
    • Shimohama, S.1    Greenwald, D.L.2    Shafron, D.H.3    Akaika, A.4    Maeda, T.5
  • 8
    • 0034006944 scopus 로고    scopus 로고
    • β-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
    • Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB. β-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem 2000; 275: 5626-5632.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5626-5632
    • Wang, H.Y.1    Lee, D.H.2    D'Andrea, M.R.3    Peterson, P.A.4    Shank, R.P.5    Reitz, A.B.6
  • 9
    • 0033846169 scopus 로고    scopus 로고
    • Nicotinic treatment for degenerative and neuropsyquiatric disorders such as Alzheimer's disease and Parkinson's disease
    • Rusted JM, Newhouse PA, Levin ED. Nicotinic treatment for degenerative and neuropsyquiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res 2000; 113: 121-129.
    • (2000) Behav. Brain Res. , vol.113 , pp. 121-129
    • Rusted, J.M.1    Newhouse, P.A.2    Levin, E.D.3
  • 10
    • 0028890920 scopus 로고
    • Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology
    • Perry EK, Morris CM, Court JA, Cheng A, Fairbairn AF, McKeith IG, et al. Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology. Neurosci 1995; 64: 385-395.
    • (1995) Neurosci. , vol.64 , pp. 385-395
    • Perry, E.K.1    Morris, C.M.2    Court, J.A.3    Cheng, A.4    Fairbairn, A.F.5    McKeith, I.G.6
  • 11
    • 0028916581 scopus 로고
    • Kinetic analysis of regional (S)(-)11C-nicotine binding in normal and Alzheimer brains - In vivo assessment using positron emission tomography
    • Nordberg A, Lundqvist H, Hartvig P, Lilja A, Langstrom B. Kinetic analysis of regional (S)(-)11C-nicotine binding in normal and Alzheimer brains - in vivo assessment using positron emission tomography. Alzheimer Dis Assoc Disord 1995; 9: 21-27.
    • (1995) Alzheimer Dis. Assoc. Disord. , vol.9 , pp. 21-27
    • Nordberg, A.1    Lundqvist, H.2    Hartvig, P.3    Lilja, A.4    Langstrom, B.5
  • 12
    • 0027370152 scopus 로고
    • In vivo detection of neurotransmitter changes in Alzheimer's disease
    • Nordberg A. In vivo detection of neurotransmitter changes in Alzheimer's disease. Ann NY Acad Sci 1993; 695: 27-33.
    • (1993) Ann. NY Acad. Sci. , vol.695 , pp. 27-33
    • Nordberg, A.1
  • 13
    • 0027399410 scopus 로고
    • Relationship between cigarette smoking and Alzheimer's disease in a population-based case-control study
    • Brenner DE, Kukull WA, Van Belle G, Bowen JD, McCormick WC, Teri L, et al. Relationship between cigarette smoking and Alzheimer's disease in a population-based case-control study. Neurology 1993; 43: 293-300.
    • (1993) Neurology , vol.43 , pp. 293-300
    • Brenner, D.E.1    Kukull, W.A.2    Van Belle, G.3    Bowen, J.D.4    McCormick, W.C.5    Teri, L.6
  • 14
    • 0023640080 scopus 로고
    • Risk factors for Alzheimer's disease: A case-control study
    • Shalat SL, Seltzer B, Pidcock C, Baker EL Jr. Risk factors for Alzheimer's disease: a case-control study. Neurology 1987; 37: 1630-1633.
    • (1987) Neurology , vol.37 , pp. 1630-1633
    • Shalat, S.L.1    Seltzer, B.2    Pidcock, C.3    Baker Jr., E.L.4
  • 15
    • 0025644484 scopus 로고
    • Cholinergic receptors in human brain: Effects of aging and Alzheimer's disease
    • Giacobini E. Cholinergic receptors in human brain: effects of aging and Alzheimer's disease. J Neurosci Res 1990; 27: 548-560.
    • (1990) J. Neurosci. Res. , vol.27 , pp. 548-560
    • Giacobini, E.1
  • 16
    • 0029013373 scopus 로고
    • Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex
    • Summers KL, Giacobini E. Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex. Neurochem Res 1995; 20: 753-759.
    • (1995) Neurochem. Res. , vol.20 , pp. 753-759
    • Summers, K.L.1    Giacobini, E.2
  • 17
    • 0030827671 scopus 로고    scopus 로고
    • Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors
    • Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, et al. Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors. Brain Res 1997; 765: 135-140.
    • (1997) Brain Res. , vol.765 , pp. 135-140
    • Kaneko, S.1    Maeda, T.2    Kume, T.3    Kochiyama, H.4    Akaike, A.5    Shimohama, S.6
  • 18
    • 0242694942 scopus 로고    scopus 로고
    • Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation
    • Stevens TR, Krueger SR, Fitzsimonds RM, Picciotto MR. Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation. Neurosci. 2003; 23: 10093-10099.
    • (2003) Neurosci. , vol.23 , pp. 10093-10099
    • Stevens, T.R.1    Krueger, S.R.2    Fitzsimonds, R.M.3    Picciotto, M.R.4
  • 20
    • 0024385514 scopus 로고
    • The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type
    • Sahakian B, Jones G, Levy R, Gray J, Warburton D. The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type. Br J Psychiatry 1989; 154: 797-800.
    • (1989) Br. J. Psychiatry , vol.154 , pp. 797-800
    • Sahakian, B.1    Jones, G.2    Levy, R.3    Gray, J.4    Warburton, D.5
  • 21
    • 0028287659 scopus 로고
    • Age-related effects of the nicotinic antagonist mecamylamine on cognition and behaviour
    • Newhouse PA, Potter A, Corwin J, Lenox R. Age-related effects of the nicotinic antagonist mecamylamine on cognition and behaviour. Neuropsychopharmacology 1994; 10: 93-107.
    • (1994) Neuropsychopharmacology , vol.10 , pp. 93-107
    • Newhouse, P.A.1    Potter, A.2    Corwin, J.3    Lenox, R.4
  • 22
    • 0028883095 scopus 로고
    • Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behaviour and implications for CNS therapeutics
    • Decker Mw, Brioni Jd, Bannon Aw, Arneric Sp. Diversity of neuronal nicotinic acetylcholine receptors: lessons from behaviour and implications for CNS therapeutics. Life Sci 1995; 56: 545-70.
    • (1995) Life Sci. , vol.56 , pp. 545-570
    • Decker, M.W.1    Brioni, J.D.2    Bannon, A.W.3    Arneric, S.P.4
  • 23
    • 0025898437 scopus 로고
    • Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease
    • Schroder H, Giacobini E, Struble RG, Zilles K, Maelicke A. Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease. Neurobiol Aging 1991; 12: 259-262.
    • (1991) Neurobiol. Aging , vol.12 , pp. 259-262
    • Schroder, H.1    Giacobini, E.2    Struble, R.G.3    Zilles, K.4    Maelicke, A.5
  • 24
    • 0026386753 scopus 로고
    • Dementia: The neurochemical basis of putative transmitter orientated therapy
    • Court JA, Perry EK. Dementia: the neurochemical basis of putative transmitter orientated therapy. Pharmacol Ther 1991; 52: 423-443.
    • (1991) Pharmacol. Ther. , vol.52 , pp. 423-443
    • Court, J.A.1    Perry, E.K.2
  • 25
    • 0027031286 scopus 로고
    • Neuroreceptor changes in Alzheimer disease
    • Nordberg A. Neuroreceptor changes in Alzheimer disease. Cerebrovasc Brain Metab Rev 1992; 4: 303-328.
    • (1992) Cerebrovasc. Brain Metab. Rev. , vol.4 , pp. 303-328
    • Nordberg, A.1
  • 26
    • 0032454039 scopus 로고    scopus 로고
    • Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
    • Mattson M, Pedersen WA. Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease. Int J Devl Neurosci 1998; 16: 737-753.
    • (1998) Int. J. Devl. Neurosci. , vol.16 , pp. 737-753
    • Mattson, M.1    Pedersen, W.A.2
  • 29
    • 0035147432 scopus 로고    scopus 로고
    • Dependence of vital cell function on endoplasmic reticulum calcium levels: Implications for the mechanisms underlying neuronal cell injury in different pathological states
    • Paschen W. Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states. Cell Calcium 2001; 29: 1-11.
    • (2001) Cell Calcium , vol.29 , pp. 1-11
    • Paschen, W.1
  • 30
    • 0031776912 scopus 로고    scopus 로고
    • Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores
    • Wei H, Wei W, Bredesen DE, Perry DC. Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores. Neurochem 1998; 70: 2305-2314.
    • (1998) Neurochem. , vol.70 , pp. 2305-2314
    • Wei, H.1    Wei, W.2    Bredesen, D.E.3    Perry, D.C.4
  • 31
    • 0033258544 scopus 로고    scopus 로고
    • Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
    • Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, et al. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol 1999; 1: 479-485.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 479-485
    • Katayama, T.1    Imaizumi, K.2    Sato, N.3    Miyoshi, K.4    Kudo, T.5    Hitomi, J.6
  • 32
    • 0030567769 scopus 로고    scopus 로고
    • Calcium homeostasis in aged neurons
    • Kirischuk S, Verkhratsky A. Calcium homeostasis in aged neurons. Life Sci 1996; 59: 451-459.
    • (1996) Life Sci. , vol.59 , pp. 451-459
    • Kirischuk, S.1    Verkhratsky, A.2
  • 33
    • 0028204224 scopus 로고
    • Calcium ionophore increases amyloid beta peptide production by cultured cells
    • Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry 1994; 33: 4550-4561.
    • (1994) Biochemistry , vol.33 , pp. 4550-4561
    • Querfurth, H.W.1    Selkoe, D.J.2
  • 34
    • 0030769091 scopus 로고    scopus 로고
    • Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
    • Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, et al. Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides. Nat Med 1997; 3: 1016-1020.
    • (1997) Nat. Med. , vol.3 , pp. 1016-1020
    • Hartmann, T.1    Bieger, S.C.2    Bruhl, B.3    Tienari, P.J.4    Ida, N.5    Allsop, D.6
  • 35
    • 13344282063 scopus 로고    scopus 로고
    • Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localisation to intracellular membranes in mammalian cells
    • Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, et al. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localisation to intracellular membranes in mammalian cells. Nat Med 1996; 2: 224-229.
    • (1996) Nat. Med. , vol.2 , pp. 224-229
    • Kovacs, D.M.1    Fausett, H.J.2    Page, K.J.3    Kim, T.W.4    Moir, R.D.5    Merriam, D.E.6
  • 36
    • 0028980748 scopus 로고
    • Alzheimer amyloid beta-peptides exhibit ionophore-like properties in human erythrocytes
    • Engstrom I, Ronquist G, Pettersson L, Waldenstrom A. Alzheimer amyloid beta-peptides exhibit ionophore-like properties in human erythrocytes. Eur J Clin Invest 1995; 25: 471-476.
    • (1995) Eur. J. Clin. Invest. , vol.25 , pp. 471-476
    • Engstrom, I.1    Ronquist, G.2    Pettersson, L.3    Waldenstrom, A.4
  • 37
    • 0029586704 scopus 로고
    • Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity
    • Pollard HB, Arispe N, Rojas E. Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity. Cell Mol Neurobiol 1995; 15: 513-526.
    • (1995) Cell Mol. Neurobiol. , vol.15 , pp. 513-526
    • Pollard, H.B.1    Arispe, N.2    Rojas, E.3
  • 38
    • 0022899577 scopus 로고
    • Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type
    • Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. N Engl J Med 1986; 315: 1241-1245.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1241-1245
    • Summers, W.K.1    Majovski, L.V.2    Marsh, G.M.3    Tachiki, K.4    Kling, A.5
  • 39
    • 0027526076 scopus 로고
    • Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: Assessment of attentional and mnemonic function using CANTAB
    • Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, et al. Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology (Berl) 1993; 110: 395-401.
    • (1993) Psychopharmacology (Berl.) , vol.110 , pp. 395-401
    • Sahakian, B.J.1    Owen, A.M.2    Morant, N.J.3    Eagger, S.A.4    Boddington, S.5    Crayton, L.6
  • 40
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994; 271: 992-998.
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3    Gracon, S.I.4    Lewis, K.W.5
  • 42
    • 0033668050 scopus 로고    scopus 로고
    • Galanthamine: A review of its use in Alzheimer's disease
    • Scott LJ, Goa KL. Galanthamine: a review of its use in Alzheimer's disease. Drugs 2000; 60: 1095-1122.
    • (2000) Drugs , vol.60 , pp. 1095-1122
    • Scott, L.J.1    Goa, K.L.2
  • 43
    • 0027429837 scopus 로고
    • Brain selective inhibition of acetylcholinesterase: A novel approach to therapy for Alzheimer's disease
    • Enz A, Amstutz R, Boddeke H, Gmelin G, Malanowski J. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease. Prog Brain Res 1993; 98: 431-438.
    • (1993) Prog. Brain Res. , vol.98 , pp. 431-438
    • Enz, A.1    Amstutz, R.2    Boddeke, H.3    Gmelin, G.4    Malanowski, J.5
  • 45
    • 0028918426 scopus 로고
    • Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
    • Mori F, Lai CC, Fusi F, Giacobini E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport 1995; 6: 633-636.
    • (1995) Neuroreport , vol.6 , pp. 633-636
    • Mori, F.1    Lai, C.C.2    Fusi, F.3    Giacobini, E.4
  • 46
    • 0035123732 scopus 로고    scopus 로고
    • Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease?
    • Giacobini E. Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease? CNS Drugs 2001; 15: 85-91.
    • (2001) CNS Drugs , vol.15 , pp. 85-91
    • Giacobini, E.1
  • 47
    • 0029821586 scopus 로고    scopus 로고
    • A preliminary open trial with nimodipine in patients with cognitive impairment and leukoaraiosis
    • Pantoni L, Carosi M, Amigoni S, Mascalchi M, Inzitari D. A preliminary open trial with nimodipine in patients with cognitive impairment and leukoaraiosis. Clin Neuropharmacol 1996; 19: 497-506.
    • (1996) Clin. Neuropharmacol. , vol.19 , pp. 497-506
    • Pantoni, L.1    Carosi, M.2    Amigoni, S.3    Mascalchi, M.4    Inzitari, D.5
  • 48
    • 0033059445 scopus 로고    scopus 로고
    • Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies
    • Kelliher M, Fastbom J, Cowburn RF, Bonkale W, Ohm TG, Ravid R, et al. Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies. Neuroscience 1999; 92: 499-513.
    • (1999) Neuroscience , vol.92 , pp. 499-513
    • Kelliher, M.1    Fastbom, J.2    Cowburn, R.F.3    Bonkale, W.4    Ohm, T.G.5    Ravid, R.6
  • 49
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997; 23: 134-147.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 51
    • 0012213056 scopus 로고    scopus 로고
    • Clinical and preclinical information of anti-oxidants: Idebenone and vitamin E
    • Thal L J. Clinical and preclinical information of anti-oxidants: Idebenone and vitamin E. Neurobiol Aging 1998; 19: 20.
    • (1998) Neurobiol. Aging , vol.19 , pp. 20
    • Thal, L.J.1
  • 52
    • 0028085516 scopus 로고
    • Estrogen deficiency and risk of Alzheimer's disease in women
    • Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol 1994; 140: 256-261.
    • (1994) Am. J. Epidemiol. , vol.140 , pp. 256-261
    • Paganini-Hill, A.1    Henderson, V.W.2
  • 54
    • 0033968704 scopus 로고    scopus 로고
    • An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease
    • Pappolla MA, Chyan YJ, Poeggeler B, Frangione B, Wilson G, Ghiso J, et al. An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. J Neural Transm 2000; 107: 203-231.
    • (2000) J. Neural. Transm. , vol.107 , pp. 203-231
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3    Frangione, B.4    Wilson, G.5    Ghiso, J.6
  • 55
    • 0031022142 scopus 로고    scopus 로고
    • Janus faces of NF-κB: Neurodestruction versus neuroprotection
    • Lipton SA. Janus faces of NF-κB: neurodestruction versus neuroprotection. Nat Med 1997; 3: 20-22.
    • (1997) Nat. Med. , vol.3 , pp. 20-22
    • Lipton, S.A.1
  • 56
    • 0034742675 scopus 로고    scopus 로고
    • Nuclear factor κB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection
    • Lipsky RH, Xu K, Zhu D, Kelly C, Terhakopian A, Novelli A, et al. Nuclear factor κB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection. J Neurochem 2001; 78: 254-264.
    • (2001) J. Neurochem. , vol.78 , pp. 254-264
    • Lipsky, R.H.1    Xu, K.2    Zhu, D.3    Kelly, C.4    Terhakopian, A.5    Novelli, A.6
  • 57
    • 0029040355 scopus 로고
    • In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
    • Dragunow M, Faull RL, Lawlor P, Beilharz EJ, Singleton K, Walker EB, et al. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 1995; 6: 1053-1057.
    • (1995) Neuroreport , vol.6 , pp. 1053-1057
    • Dragunow, M.1    Faull, R.L.2    Lawlor, P.3    Beilharz, E.J.4    Singleton, K.5    Walker, E.B.6
  • 58
    • 0029912056 scopus 로고    scopus 로고
    • Mechanisms of neuronal death in Alzheimer's disease
    • Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 1996; 6: 493-506.
    • (1996) Brain Pathol. , vol.6 , pp. 493-506
    • Cotman, C.W.1    Su, J.H.2
  • 59
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 60
    • 0344688198 scopus 로고    scopus 로고
    • Galanthamine prevents apoptosis induced by β-amyloid and thapsigargin: Involvement of nicotinic acetylcholine receptors
    • Arias E, Ales E, Gabilan NH, Cano-Abad ME, Villarroya M, Garcia AG, et al. Galanthamine prevents apoptosis induced by β -amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology 2004; 46: 103-114.
    • (2004) Neuropharmacology , vol.46 , pp. 103-114
    • Arias, E.1    Ales, E.2    Gabilan, N.H.3    Cano-Abad, M.E.4    Villarroya, M.5    Garcia, A.G.6
  • 61
    • 0037622682 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    • Takada Y, Yonezawa A, Kume T, Katsuki H, Kaneko S, Sugimoto H, et al. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J Pharmacol Exp Ther 2003; 306: 772-777.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 772-777
    • Takada, Y.1    Yonezawa, A.2    Kume, T.3    Katsuki, H.4    Kaneko, S.5    Sugimoto, H.6
  • 62
    • 0033729119 scopus 로고    scopus 로고
    • Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: A model of the membrane defect of Alzheimer's disease
    • Farber SA, Slack BE, Blusztajn JK. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J 2000; 14: 2198-2206.
    • (2000) FASEB J. , vol.14 , pp. 2198-2206
    • Farber, S.A.1    Slack, B.E.2    Blusztajn, J.K.3
  • 63
    • 0033403796 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion
    • Alvarez XA, Mouzo R, Pichel V, Perez P, Laredo M, Fernandez-Novoa L, et al. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods Find Exp Clin Pharmacol 1999; 21: 633-644.
    • (1999) Methods Find Exp. Clin. Pharmacol. , vol.21 , pp. 633-644
    • Alvarez, X.A.1    Mouzo, R.2    Pichel, V.3    Perez, P.4    Laredo, M.5    Fernandez-Novoa, L.6
  • 64
    • 0022435132 scopus 로고
    • Image reconstruction of the Alzheimer paired helical filament
    • Crowther RA, Wischik CM. Image reconstruction of the Alzheimer paired helical filament. EMBO J 1985; 4: 3661-3665.
    • (1985) EMBO J. , vol.4 , pp. 3661-3665
    • Crowther, R.A.1    Wischik, C.M.2
  • 65
    • 0034680902 scopus 로고    scopus 로고
    • Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain
    • Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett 2000; 485: 87-93,
    • (2000) FEBS Lett. , vol.485 , pp. 87-93
    • Bennecib, M.1    Gong, C.X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 66
    • 0032731763 scopus 로고    scopus 로고
    • Brain inflammation in Alzheimer disease and the therapeutic implications
    • Mcgeer EG, Mcgeer PL. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr Pharm Des 1999; 5: 821-836.
    • (1999) Curr. Pharm. Des. , vol.5 , pp. 821-836
    • Mcgeer, E.G.1    Mcgeer, P.L.2
  • 68
    • 0034254924 scopus 로고    scopus 로고
    • Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
    • Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 2000; 20: 5709-5714.
    • (2000) J. Neurosci. , vol.20 , pp. 5709-5714
    • Lim, G.P.1    Yang, F.2    Chu, T.3    Chen, P.4    Beech, W.5    Teter, B.6
  • 69
    • 0034639568 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs with selectivity for cyclooxygenase-2 in Alzheimer's disease. Rationale and perspectives
    • Blain H, Jouzeau JY, Blain A, Terlain B, Trechot P, Touchon J, et al. Non-steroidal anti-inflammatory drugs with selectivity for cyclooxygenase-2 in Alzheimer's disease. Rationale and perspectives. Presse Med 2000; 29: 267-273,
    • (2000) Presse Med. , vol.29 , pp. 267-273
    • Blain, H.1    Jouzeau, J.Y.2    Blain, A.3    Terlain, B.4    Trechot, P.5    Touchon, J.6
  • 70
    • 0033615580 scopus 로고    scopus 로고
    • The presenilins in' Alzheimer's disease- proteolysis holds the key
    • Haass C, De Strooper B. The presenilins in' Alzheimer's disease- proteolysis holds the key. Science 1999; 286: 916-919.
    • (1999) Science , vol.286 , pp. 916-919
    • Haass, C.1    De Strooper, B.2
  • 71
    • 0024417125 scopus 로고
    • Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease
    • Geula C, Mesulam M. Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain Res 1989; 498: 185-189.
    • (1989) Brain Res. , vol.498 , pp. 185-189
    • Geula, C.1    Mesulam, M.2
  • 72
    • 0029863697 scopus 로고    scopus 로고
    • Acety1cholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
    • Inestrosa NC, Alvarez A, Pérez CA, Moreno RD, Vicente M, Linker C, et al. Acety1cholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron 1996; 16: 881-891.
    • (1996) Neuron. , vol.16 , pp. 881-891
    • Inestrosa, N.C.1    Alvarez, A.2    Pérez, C.A.3    Moreno, R.D.4    Vicente, M.5    Linker, C.6
  • 73
    • 0031587286 scopus 로고    scopus 로고
    • Acetylcholinesterase promotes the aggregation of amyloid β-peptide fragments by forming a complex with the growing fibrils
    • Álvarez A, Opazo C, Alarcón R, Garrido J, Inestrosa NC. Acetylcholinesterase promotes the aggregation of amyloid β-peptide fragments by forming a complex with the growing fibrils. J Mol Biol 1997; 272: 348-361.
    • (1997) J. Mol. Biol. , vol.272 , pp. 348-361
    • Álvarez, A.1    Opazo, C.2    Alarcón, R.3    Garrido, J.4    Inestrosa, N.C.5
  • 74
    • 0034488989 scopus 로고    scopus 로고
    • Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity
    • Inestrosa NC, Álvarez A, Godoy J, Reyes A, De Ferrari GV. Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity. Acta Neurol Scand 2000; 176: 53-59.
    • (2000) Acta Neurol. Scand. , vol.176 , pp. 53-59
    • Inestrosa, N.C.1    Álvarez, A.2    Godoy, J.3    Reyes, A.4    De Ferrari, G.V.5
  • 75
    • 0037298750 scopus 로고    scopus 로고
    • β-amyloid aggregation induced by human acetylcholinesterase: Inhibition studies
    • Bartolini M, Bertucci C, Cavrini V, Andrisano V. β-amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem Pharmacol 2003; 65: 407-416.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 407-416
    • Bartolini, M.1    Bertucci, C.2    Cavrini, V.3    Andrisano, V.4
  • 76
    • 0028197477 scopus 로고
    • Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines
    • Lahiri DK, Lewis S, Farlow MR. Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. J Neurosci Res 1994; 37: 777-787.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 777-787
    • Lahiri, D.K.1    Lewis, S.2    Farlow, M.R.3
  • 77
    • 0032569990 scopus 로고    scopus 로고
    • The secretion of amyloid β-peptides is inhibited in the tacrine-treated human neuroblastoma cells
    • Lahiri DK, Farlow MR, Sambamurti K. The secretion of amyloid β-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res Mol 1998; 62: 131-140.
    • (1998) Brain Res. Mol. , vol.62 , pp. 131-140
    • Lahiri, D.K.1    Farlow, M.R.2    Sambamurti, K.3
  • 78
    • 0035912825 scopus 로고    scopus 로고
    • Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
    • Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A. Ge YW, et al. Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci USA 2001; 98: 7605-7610.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7605-7610
    • Shaw, K.T.1    Utsuki, T.2    Rogers, J.3    Yu, Q.S.4    Sambamurti, K.5    Brossi, A.6    Ge, Y.W.7
  • 81
    • 0036315026 scopus 로고    scopus 로고
    • Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: Correlation with cognitive benefit
    • Giacobini E, Spiegel R, Enz A, Veroff AE, Cutler NR. Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit. J Neural Transm 2002; 109: 1053-1065.
    • (2002) J. Neural Transm. , vol.109 , pp. 1053-1065
    • Giacobini, E.1    Spiegel, R.2    Enz, A.3    Veroff, A.E.4    Cutler, N.R.5
  • 82
    • 0025213932 scopus 로고
    • Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain
    • Siek GC, Katz LS, Fishman EB, Korosi TS, Marquis JK. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biol Psychiatry 1990; 27: 573-580.
    • (1990) Biol. Psychiatry , vol.27 , pp. 573-580
    • Siek, G.C.1    Katz, L.S.2    Fishman, E.B.3    Korosi, T.S.4    Marquis, J.K.5
  • 83
    • 0028709150 scopus 로고
    • Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors
    • Weinstock M, Razin M, Chorev M, Enz A. Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors. J Neural Transm Suppl 1994; 43: 219-225.
    • (1994) J. Neural Transm. Suppl. , vol.43 , pp. 219-225
    • Weinstock, M.1    Razin, M.2    Chorev, M.3    Enz, A.4
  • 84
    • 0033845742 scopus 로고    scopus 로고
    • Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
    • Maelicke A, Schrattenholz A, Samochocki M, Radina M, Albuquerque E. Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease. Behav Brain Res 2000; 113: 199-206.
    • (2000) Behav. Brain Res. , vol.113 , pp. 199-206
    • Maelicke, A.1    Schrattenholz, A.2    Samochocki, M.3    Radina, M.4    Albuquerque, E.5
  • 85
    • 0035105750 scopus 로고    scopus 로고
    • Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
    • Marco J L, De Los Ríos C, Carreiras MDC, Baõs JE, Badía A, Vivas N. Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues. Bioorg Med Chem 2001; 9 (Suppl. 3): 727-732.
    • (2001) Bioorg. Med. Chem. , vol.9 , Issue.SUPPL. 3 , pp. 727-732
    • Marco, J.L.1    De Los Ríos, C.2    Carreiras, M.D.C.3    Baõs, J.E.4    Badía, A.5    Vivas, N.6
  • 87
    • 0032545384 scopus 로고    scopus 로고
    • Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes
    • Canti C, Bodas E, Marsal J, Solsona C. Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes. Eur J Pharmacol 1998; 363: 197-202.
    • (1998) Eur. J. Pharmacol. , vol.363 , pp. 197-202
    • Canti, C.1    Bodas, E.2    Marsal, J.3    Solsona, C.4
  • 88
    • 0031565285 scopus 로고    scopus 로고
    • Distinct effects of ω-toxins and various groups of Ca(2+)-entry inhibitors on nicotinic acetylcholine receptor and Ca2+ channels of chromaffin cells
    • Villarroya M, De La Fuente MT, López MG, Gandía L, Garcia AG. Distinct effects of ω-toxins and various groups of Ca(2+)-entry inhibitors on nicotinic acetylcholine receptor and Ca2+ channels of chromaffin cells. Eur J Pharmacol 1997; 320: 249-57.
    • (1997) Eur. J. Pharmacol. , vol.320 , pp. 249-257
    • Villarroya, M.1    De La Fuente, M.T.2    López, M.G.3    Gandía, L.4    Garcia, A.G.5
  • 89
    • 0037286233 scopus 로고    scopus 로고
    • Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): Targets for the development of novel therapeutics against neurodegenerative diseases
    • Campiani G, Fattorusso C, De Angelis M, Catalanotti B, Butini S, Fattorusso R, el al. Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. Curr Pharm Design 2003; 9(8): 599-625.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.8 , pp. 599-625
    • Campiani, G.1    Fattorusso, C.2    De Angelis, M.3    Catalanotti, B.4    Butini, S.5    Fattorusso, R.6
  • 90
    • 0041677655 scopus 로고    scopus 로고
    • A point of view: The need to identify an antigen in psyconeurommumological disorders
    • Covelli V, Pellegrino NM, Jirillo E. A point of view: The need to identify an antigen in psyconeurommumological disorders. Curr Pharm Design 2003; 9(24): 1951-5.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.24 , pp. 1951-1955
    • Covelli, V.1    Pellegrino, N.M.2    Jirillo, E.3
  • 91
    • 0037242768 scopus 로고    scopus 로고
    • Peptidases, proteases and amyloid beta-peptide catabolism
    • Hersh LB. Peptidases, proteases and amyloid beta-peptide catabolism. Curr Pharm Design 2003; 9(6): 449-54.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.6 , pp. 449-454
    • Hersh, L.B.1


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