Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-β estradiol and induces the activity of the transcription factor NF-κB

Journal of Neural Transmission

Volumn 107, Issue 4, 2000, Pages 393-407

  Behl, C ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

17 estradiol; Glutamate; Neuroprotection; NF B; Oxidative stress; Vitamin E; tocopherol

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ESTRADIOL; GLUTAMIC ACID; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CLONE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; HIPPOCAMPUS; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0034026089     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020070082     Document Type: Article

References (56)

1. Adler LA, Edson R, Lavori P, Peselow E, Duncan E, Rosenthal M, Rotrosen J (1998) Long-term treatment effects of vitamin E for tardive dyskinesia. Biol Psych 43: 868-872
2. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90: 7915-7922
3. Ayres S, Tang MY, Subbiah MTR (1996) Estradiol-17-β as an antioxidant - some distinct features when compared with common fat-soluble antioxidants. J Lab Clin Med 128: 367-375
4. Azzi A, Boscoboinik D, Marilley D, Ozer NK, Stauble B, Tasinato A (1995) Vitamin E - a sensor and an information transducer of the cell oxidation state. Am J Clin Nutr 62: 1337-1346
5. Baldwin AS (1996) The NF-κB and 1κB proteins: new discoveries and insights. Annu Rev Immunol 14: 649-681
6. Barger SW, Mattson MP (1996) Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor. Mol Brain Res 40: 116-126
7. Barner EL, Gray SL (1998) Donepezil use in Alzheimer disease. Ann Pharmacother 32: 70-77
8. Beal MF (1995) Aging, energy, and oxidative stress in neurodegnerative diseases. Ann Neurol 38: 357-366
9. Behl C (1999) Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches. Prog Neurobiol 57: 301-323
10. Behl C, Davis J, Cole GM, Schubert D (1992) Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem Biophys Res Commun 186: 944-952
11. Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77: 817-822
12. Behl C, Widmann M, Trapp T, Holsboer F (1995) 17-β estradiol protects from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216: 473-482
13. Behl C, Widmann M, Trapp T, Holsboer F (1995) 17-β estradiol protects from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216: 473-482
14. Behl C, Trapp T, Skutella T, Holsboer F (1997a) Protection against oxidative stress-induced neuronal cell death - a novel role for RU486. Eur J Neurosci 9: 912-920
15. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton C, Holsboer F (1997b) Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51: 535-541
16. Bolkenius FN, Vernemismer J, Wagner J, Grisar JM (1996) Amphiphilic α-tocopherol analogues as inhibitors of brain lipid peroxidation. Eur J Pharmacol 298: 37-43
17. Burton GW, Traber MG, Acuff RV, Walters DN, Kayden H, Hughes L, Ingold KU (1998) Human plasma and tissue α-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr 67: 669-684
18. Cadet JL, Kahler LA (1994) Free radical mechanisms in schizophrenia and tardive dyskinesia. Neurosci Biobehav Rev 18: 457-467
19. Choi DW (1992) Excitotoxic cell death. J Neurobiol 23: 1261-1276
20. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695
21. Fridovich I (1978) The biology of oxygen radicals. Science 201: 875-880
22. Gardos G, Cole JO (1995) The evaluation and treatment of neuroleptic-induced movement disorders. Harvard Rev Psychiatry 3: 130-139
23. Gerlach M, Riederer P (1996) Pathogenesis and attempts at neuroprotective tratement in chronic degenerative diseases - the role of anti-oxidants. Med Klin 91: 163-170
24. Green PS, Bishop J, Simpkins JW (1997) 17α-Estradiol exerts neuroprotective effects on SK-N-SH cells. J Neurosci 17: 511-515
25. Grilli M, Pizzi M, Memo M, Spano P (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 274: 1383-1385
26. Halliwell B (1990) How to characterize a biological antioxidant. Free Rad Res Comm 9: 1-32
27. Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine, 2nd edn. Oxford University Press, Oxford, pp 645-651
28. Harris ME, Hensley K, Butterfield A, Leedle RA, Carney JM (1995) Direct evidence of oxidative injury produced by the Alzheimer's β-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 131: 193-202
29. Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, Buckwalter JG (1994) Estrogen replacement therapy in older women. Arch Neurol 51: 896-900
30. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-κB -B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94: 2642-2647
31. -· free radicals. Life Sci 63: 769-779
32. Lezoualc'h F, Behl C (1998) Transcription factor NF-κB: friend or foe of neurons? Mol Psychiatry 3: 15-20
33. Lezoualc'h F, Skutella T, Widmann M, Behl C (1996) Melatonin prevents oxidative stress-induced cell death in hippocampal cells. NeuroReport 7: 2071-2077
34. Lezoualc'h F, Sparapani M, Behl C (1998a) N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-κB. J Pineal Res 24: 168-178
35. Lezoualc'h F, Sagara Y, Holsboer F, Behl C (1998b) High constitutive NF-κB activity mediates resistance to oxidative stress in neuronal cells. J Neurosci 18: 3224-3232
36. Lipton SA (1997) Janus faces of NF-kappa B: neurodestruction versus neuroprotection. Nature Med 3: 20-22
37. Louvel E, Hugon J, Doble A (1997) Therapeutic advances in amyotrophic lateral sclerosis. Trends Pharmacol Sci 18: 196-203
38. Maher P, Davis J (1996) The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci 15: 6394-6401
39. Markesbery WR (1997) Oxidative stress in Alzheimer's disease. Free Rad Biol Med 23: 134-147
40. Mookjung I, Joo I, Sohn S, Kwon HJ, Huh K, Jung MW (1997) Estrogen blocks the neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells. Neurosci Lett 235: 101-104
41. Moosmann B, Uhr M, Behl C (1997) Neuroprotective potential of aromatic alcohols against oxidative cell death. FEBS Lett 413: 467-472
42. Paganini-Hill A, Henderson VW (1994) Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol 140: 256-261
43. Palmer HJ, Paulson KE (1997) Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 55: 353-361
44. Parthasarathy S, Steinberg D, Witztum JL (1992) The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annu Rev Med 43: 219-225
45. Post A, Holsboer F, Behl C (1998) Induction of NF-κB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells - suppression of NF-κB and neuroprotection by antioxidants. J Neurosci 18: 8236-8246
46. Sano M, Ernesto C, Thomas RG et al. (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 336: 1216-1222
47. Schmidt KN, Amstad P, Cerutti P, Bäuerle PA (1995) The roles of hydrogen peroxide and Superoxide as messengers in the activation of transcription factor NF-κB. Chem Biol 2: 13-22
48. Schreck R, Rieber P, Bäuerle PA (1991) Reactive oxygen intermediates are apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 10: 2247-2258
49. Schubert D, Kimura H, Maher P (1992) Growth factors and vitamin E modify neuronal glutamate toxicity. Proc Natl Acad Sci USA 89: 8264-8267
50. Schulze-Osthoff K, Los M, Bäuerle PA (1995) Redox signalling by transcription factors NF-κB and AP-1 in the immune system. Biochem Pharmacol 50: 735-741
51. Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46: 705-706
52. Sugioka K, Shimosegawa Y, Nakano M (1987) Estrogens as natural antioxidants of membrane phospholipid peroxidation. FEBS Lett 210: 37-39
53. Takahashi H, Kosaka N, Nakagawa S (1998) α-Tocopherol protects PC12 cells from hyperoxia-induced apoptosis. J Neurosci Res 52: 184-191
54. Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R (1996) Effect of oestrogen during menopause on risk and age of onset of Alzheimer's disease. Lancet 348: 429-432
55. Wu M, Lee HY, Bellas RE, Schauer SL, Arsura M, Katz D, Fitzgerald MJ, Rothstein TL, Sherr DH, Sonenshein GE (1996) Inhibition of NF-κB/rel induces apoptosis of murine B cells. EMBO J 15: 4682-4690
56. Yankner BA (1996) Mechanism of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932