Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 19947-19958

  Luo, Jialie ^a,b   Li, Wenming ^a   Zhao, Yuming ^b   Fu, Hongjun ^a   Ma, Dik Lung ^c   Tang, Jing ^d   Li, Chaoying ^e   Peoples, Robert W ^f   Li, Fushun ^g   Wang, Qinwen ^g   Huang, Pingbo ^b   Xia, Jun ^b   Pang, Yuanping ^d   Han, Yifan ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d MAYO CLINIC   (United States)

^e JIANGHAN UNIVERSITY   (China)

^f MARQUETTE UNIVERSITY   (United States)

^g NINGBO UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMINOBUTYRIC ACIDS; BRAIN DAMAGE; DRUG CANDIDATES; EXCITOTOXICITY; HIPPOCAMPAL NEURONS; HIPPOCAMPAL SLICE; HYDROPHOBIC INTERACTIONS; INHIBITORY EFFECT; ION CHANNEL; KINETICS ANALYSIS; LONG-TERM POTENTIATIONS; MEMANTINE; MIDDLE CEREBRAL ARTERY; MOLECULAR DOCKING SIMULATIONS; N METHYL D ASPARTATE RECEPTOR; N-METHYL-D-ASPARTATE; NEURODEGENERATIVE DISORDERS; NEUROPROTECTION; NMDA RECEPTOR; PATHOLOGICAL CONDITIONS; PHYSIOLOGICAL CONDITION; RECEPTOR ANTAGONISTS; TIME CONSTANTS;

AMINO ACIDS; BRAIN;

HYDROPHOBICITY;

BIS(PROPYL) COGNITIN; CHOLINESTERASE INHIBITOR; DIMER; DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMICAL BINDING; CONTROLLED STUDY; DRUG ACTIVITY; GENE MUTATION; HYDROPHOBICITY; KINETICS; LONG TERM POTENTIATION; MOLECULAR DOCKING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DIMERIZATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; KINETICS; MALE; MEMBRANE POTENTIALS; MODELS, MOLECULAR; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TACRINE; TRANSFECTION;

RATTUS;

EID: 77953753022     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.111286     Document Type: Article

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