An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons

Apoptosis

Volumn 14, Issue 7, 2009, Pages 900-912

  Jantas, D ^a   Szymanska, M ^a   Budziszewska, B ^a   Lason, W ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Intracellular calcium level; JC 1; Neuronal apoptosis; Neurotoxicity; NMDA receptor antagonist; Wortmannin

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 2 MORPHOLINO 8 PHENYLCHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM ION; DIZOCILPINE; GLYCOGEN SYNTHASE KINASE 3BETA; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAUROSPORINE; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM; CEREBRAL CORTEX; DIZOCILPINE MALEATE; DOPAMINE AGENTS; ENZYME INHIBITORS; FEMALE; MEMANTINE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; STAUROSPORINE;

EID: 67649619588     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0370-6     Document Type: Article

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