γ-Secretase: Characterization and implication for Alzheimer disease therapy

Neurobiology of Aging

Volumn 23, Issue 6, 2002, Pages 1023-1030

  Xu, Min ^a   Lai, Ming Tain ^a   Huang, Qian ^a   DiMuzio Mower, Jillian ^a   Castro, José L ^b   Harrison, Timothy ^b   Nadin, Alan ^b   Neduvelil, Joseph G ^b   Shearman, Mark S ^b   Shafer, Jules A ^a,c   Gardell, Stephen J ^a,d   Li, Yue Ming ^a,e  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c B24 2 ^*  (United States)

^d BAYER CORPORATION   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Secretase; Alzheimer's disease; Presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; ENZYME ANALYSIS; ENZYME ASSAY; HUMAN; IN VITRO STUDY; MEMBRANE; NEUROPATHOLOGY; PHOTOREACTIVITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CARBAMATES; DIPEPTIDES; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE PROTEINS; PRESENILIN-1; PRESENILIN-2; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0036861121     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(02)00126-4     Document Type: Article

References (39)

1. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T.et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate in Aβl-42, 1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
2. Brown M.S., Ye J., Rawson R.B., Goldstein J.L. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 100:2000;391-398.
3. Cai H., Wang Y., McCarthy D., Wen H., Borchelt D.R., Price D.L.et al. BACE1 is the major β-secretase for generation of Ab peptides by neurons. Nat. Neurosci. 4:2001;233-234.
4. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W.et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1998;387-390.
5. Doerfler P., Shearman M.S., Perlmutter R.M. Presenilin-dependent γ-secretase activity modulates thymocyte development. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9312-9317.
6. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-Turn J.et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
7. Esler W.P., Kimberly T.W., Ostaszewski B.L., Diehl T.S., Moore C.L., Tsai J.Y.et al. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1. Nat. Cell Biol. 2:2000;428-434.
8. Figueroa D.J., Morris J.A., Ma L., Kandpal G., Chen E., Li Y.M.et al. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiol. Dis. 9:2002;49-60.
9. Hadland B.K., Manley N.R., Su D.M., Longmore G.D., Moore C.L., Wolfe M.S.et al. γ-Secretase inhibitors repress thymocyte development. Proc. Natl. Acad. Sci. U.S.A. 98:2001;7487-7491.
10. Herreman A., Serneels L., Annaert W., Collen D., Schoonjans L., De Strooper B. Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells. Nat. Cell Biol. 2:2000;461-462.
11. Hussain I., Powell D., Howwlett D.R., Tew D.G., Meek T.D., Chapman C.et al. Identification of a novel aspartic protease (Asp2) as β-secretase. Mol. Cell Neurosci. 14:1999;419-427.
12. Kopan R., Goate A. A common enzyme connects Notch signaling and Alzheimer's disease. Genes Dev. 14:2000;2799-2806.
13. Kopan R., Goate A. Aph-2/Nicastrin: an essential component of γ-secretase and regulator of Notch signaling and presenilin localization. Neuron. 33:2002;321-324.
14. Levy-Lahad E., Wijsman E.M., Nemens E., Anderson L., Goddard K.A., Weber J.L.et al. A familial Alzheimer's disease locus on chromosome 1. Science. 269:1995;970-973.
15. Li Y.M. γ-Secretase: a catalyst of Alzheimer disease and signal transduction. Mol. Interven. 1:2001;198-207.
16. Li Y.M., Lai M.T., Xu M., Huang Q., Claiborne C.F., DiMuzio-Mower J.et al. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. U.S.A. 97:2000;6138-6143.
17. Li Y.M., Marnerakis M., Stimson E.R., Maggio J.E. Mapping peptide-binding domains of the Substance P (NK-1) receptor from P388D1 cells with photolabile agonists. J. Biol. Chem. 270:1995;1213-1220.
18. Li Y.M., Xu M., Lai M.T., Huang Q., Castro J.L., DiMuzio-Mower J.et al. Photoactivated γ-secretase inhibitors directly to the active site covalently label presenilin 1. Nature. 405:2000;689-694.
19. Luo Y., Bolon B., Kahn S., Bennett B.D., Babu-Khan S., Denis P.et al. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nat. Neurosci. 4:2001;231-232.
20. Martys-Zage J.L., Kim S.H., Berechid B., Bingham S.J., Chu S., Sklar J.et al. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J. Mol. Neurosci. 15:2000;189-204.
21. Naruse S., Thinakaran G., Luo J.J., Kusiak J.W., Tomita T., Iwatsubo T.et al. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21:1998;1213-1221.
22. Ni C.Y., Murphy M.P., Golde T.E., Csrpenter G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science. 294:2001;2179-2181.
23. Petit A., Bihel F., da-Costa C.A., Pourquie O., Checler F., Kraus J.L. New protease inhibitors prevent gamma-secretase-mediated production of Aβ 40/42 without affecting Notch cleavage. Nat. Cell Biol. 3:2001;507-511.
24. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N.et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
25. Seiffert D., Bradley D.J., Rominger M.C., Rominger H.D., Yang F., Meredith E.J.J.et al. Presenilin-1 and 2 are molecular targets for γ-secretase inhibitors. J. Biol. Chem. 275:2000;34086-34091.
26. Shearman M.S., Beher D., Clarke E.E., Lewis H.D., Harrison T., Hunt P.et al. L-685,458, an aspartic protease transition state mimic, is a potent inhibitor of APP γ-secretase activity. Biochemistry. 39:2000;8698-8704.
27. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M.et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
28. Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D.et al. Purification and cloning of amyloid precursor protein b-secretase from human brain. Nature. 402:1999;537-540.
29. Sisodia S.S., Annaert W., Kim S.H., De Strooper B. γ-Secretase: never more enigmatic. Trends Neurosci. 24:2001;S2-S6.
30. Steiner H., Kostka M., Roming H., Basset G., Pesold B., Hardy J.et al. Glysine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat. Cell Biol. 2:2000;848-851.
31. Tamaoka A., Fraser P.E., Ishii K., Sahara N., Ozawa K., Ikeda M.et al. Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer's disease. Mol. Brain Res. 56:1998;178-185.
32. Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G.et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17:1996;181-190.
33. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P.et al. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:1999;735-741.
34. Weggen S., Eriksen J.L., Das P., Sagi S.A., Wang R., Pletrzik C.U.et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature. 414:2001;212-216.
35. Wolfe M.S., Xia W., Moore C.L., Leatherwood D.D., Ostaszewski B., Rahmati T.et al. Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 38:1999;4720-4727.
36. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature. 398:1999;513-517.
37. Yan R., Bienkowski M., Shuck M.E., Miao H., Tory M.C., Pauley A.M.et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature. 402:1999;533-537.
38. Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A.et al. A novel protein (Nicastrin) modulates presenilin-mediated Notch/Glp1 and APP preocessing. Nature. 407:2000;48-54.
39. Zhang Z., Nadeau P., Song W., Donoviel D., Yuan M., Bernstein A.et al. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2:2000;463-465.