Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 95-103

  Xing, Weiqiang ^a   Fu, Yan ^a   Shi, Zhangxing ^a   Lu, Dong ^a   Zhang, Haiyan ^a   Hu, Youhong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Docking study; Pyridazinone

Indexed keywords

4 (MORPHOLINE 4 CARBONYL) N [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1 CARBOXAMIDE; CHOLINESTERASE INHIBITOR; DIETHYL N 1 [3 [[6 OXO 3 (O TOLYL)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 1 [3 [[3 (3 BROMOPHENYL) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL] N 4 ,N 4 DIETHYLPIPERIDINE 1,4 DICARBOXAMIDE; N 1 [3 [[3 (3 CHLOROPHENYL) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL] N 4 ,N 4 DIETHYLPIPERIDINE 1,4 DICARBOXAMIDE; N 1 [3 [[3 (3 CYANOPHENYL) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL] N 4 ,N 4 DIETHYL PIPERIDINE 1,4 DICARBOXAMIDE; N 1 [3 [[3 [(2,6 DIMETHYLPHENYL)AMINO] 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL] N 4 ,N 4 DIETHYLPIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [(6 OXO 3 PHENYLPYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [(6 OXOPYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[3 (NAPHTHALEN 1 YL) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[3 (NAPHTHALEN 1 YLAMINO) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[3 (NAPHTHALEN 2 YL) 6 OXOPYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[3 [(2 ETHYLPHENYL)AMINO] 6 OXOPYRIDAZIN 1 (6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[3 [(2 ISOPROPYLPHENYL)AMINO] 6 OXOPYRIDAZIN 1 (6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (M TOLYLAMINO)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (M-TOLYL)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (P TOLYL)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (P TOLYLAMINO)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 (PHENYLAMINO)PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 [(2 (TRIFLUOROMETHYL)PHENYL)AMINO]PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 [(3 (TRIFLUOROMETHYL)PHENYL)AMINO]PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIETHYL N 1 [3 [[6 OXO 3 [(4 (TRIFLUOROMETHYL)PHENYL)AMINO]PYRIDAZIN 1(6H) YL]METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIISOPROPYL N 1 [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ,N 4 DIMETHYL N 1 [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ETHYL N 4 ISOPROPYL N 1 [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ETHYL N 4 METHYL N 1 [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; N 4 ISOPROPYL N 4 METHYL N 1 [3 [(6 OXO 3 (O TOLYLAMINO)PYRIDAZIN 1(6H) YL)METHYL]PHENYL]PIPERIDINE 1,4 DICARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BINDING, COMPETITIVE; BIOCATALYSIS; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874403236     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.056     Document Type: Article

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