Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1682-1693

  Belluti, Federica ^a   Bartolini, Manuela ^a   Bottegoni, Giovanni ^b   Bisi, Alessandra ^a   Cavalli, Andrea ^a,b   Andrisano, Vincenza ^a   Rampa, Angela ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Amyloid; Benzophenone; Drug design; Molecular modeling

Indexed keywords

(4 AMINOPHENYL)[4 [[BENZYL(METHYL)AMINO]METHYL]PHENYL]METHANONE; 1 [1 [3 [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENOXY]PROPYL]PIPERIDIN 4 YL] 1,3 DIHYDROBENZOIMIDAZOL 2 ONE; 4 BROMOMETHYL 4' NITROBENZOPHENONE; 5 CHLOROPENTANOIC ACID [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENYL]AMIDE; 5 PIPERIDIN 1 YLPENTANOICACID[4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENYL]AMIDE; [4 [(BENZYL(METHYL)AMINO]METHYL]PHENYL](4 NITROPHENYL)METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] (4 HYDROXYPHENYL)METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (3 CHLOROPROPOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (3 DIETHYLAMINOPROPOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (3 MORPHOLIN 4 YLPROPOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (3 PIPERIDIN 1 YLPROPOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (5 CHLOROPENTYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (5 DIETHYLAMINOPENTYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (5 PIPERIDIN 1 YLPENTYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (6 CHLOROHEXYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (6 DIETHYLAMINOHEXYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (6 PIPERIDIN 1 YLHEXYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (7 BROMOHEPTYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 (7 DIETHYLAMINOHEPTYLOXY)PHENYL]METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL] [4 [4 (2 HYDROXYETHYL)PHENOXY]PHENYL}METHANONE; [4 [(BENZYLMETHYLAMINO)METHYL]PHENYL](4 METHOXYPHENYL)METHANONE; AMYLOID BETA PROTEIN; BENZOPHENONE DERIVATIVE; BENZYL (4 BROMOBENZYL)METHYLAMINE; CHOLINESTERASE INHIBITOR; N [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENYL] 2 DIETHYLAMINOACETAMIDE; N [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENYL] 2 MORPHOLIN 4 YL ACETAMIDE; N [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYL]PHENYL] 2 PIPERIDIN 1 YL ACETAMIDE; N [4 [4 [(BENZYLMETHYLAMINO)METHYL]BENZOYLPHENYL] 2 CHLOROACETAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG PROTEIN BINDING; ENZYME INHIBITION; PROTEIN AGGREGATION;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; BENZOPHENONES; CHOLINESTERASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MONTE CARLO METHOD; PEPTIDE FRAGMENTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953214018     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.019     Document Type: Article

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