Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2707-2718

  Contreras, J M ^a   Parrot, I ^a   Sippl, W ^b   Rival, Y M ^a   Wermuth, C G ^a  

^a Laboratoire de Pharmacochimie   (France)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYLAMINO] 5 METHYL 6 PHENYLPYRIDAZINE; 3 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYLAMINO] 5H INDENO [1,2 C]PYRIDAZINE; 3 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYLAMINO]PYRIDAZINE DERIVATIVE; CHOLINESTERASE INHIBITOR; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; ELECTROPHORUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; PYRIDAZINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 0035899187     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001088u     Document Type: Article

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