Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 296-301

  Samadi, Abdelouahid ^a   Estrada, Martín ^b   Pérez, Concepción ^b   Rodríguez Franco, María Isabel ^b   Iriepa, Isabel ^c   Moraleda, Ignacio ^c   Chioua, Mourad ^a   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

ADME; Alzheimer's disease; Dual AChE inhibitors; hAChE; hBuChE; In vitro blood brain barrier; Molecular modeling; Pyridonepezils

Indexed keywords

2 AMINO 6 [[3 (1 BENZYLPIPERIDIN 4 YL)PROPYL]AMINO]PYRIDINE 3,5 DICARBONITRILE; CHOLINESTERASE INHIBITOR; DONEPEZIL; PYRIDONEPEZIL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR MODEL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOPYRIDINES; BINDING SITES; BLOOD-BRAIN BARRIER; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ENZYME ASSAYS; HUMANS; INDANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NITRILES; PERMEABILITY; PIPERIDINES; PROTEIN BINDING; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867360947     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.030     Document Type: Article

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