Tacrine-ferulic acid-nitric oxide (no) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4309-4321

  Chen, Yao ^a,b   Sun, Jianfei ^a   Fang, Lei ^a   Liu, Mei ^a   Peng, Sixun ^a   Liao, Hong ^a   Lehmann, Jochen ^b,c   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

2 [ 2 METHOXY 4 [ 3 OXO 3 ( 2 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYLAMINO)PROP 1 ENYL]PHENOXY]ETHYL NITRIC ACID; 2 [ 2 METHOXY 4 [ 3 OXO 3 ( 3 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYLAMINO)PROP 1 ENYL]PHENOXY]ETHYL NITRIC ACID; 2 [ 2 METHOXY 4 [ 3 OXO 3 ( 4 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYLAMINO)PROP 1 ENYL]PHENOXY]ETHYL NITRIC ACID; 2 [ 2 METHOXY 4 [ 3 OXO 3 ( 6 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO)PROP 1 ENYL]PHENOXY]ETHYL NITRIC ACID; 2 [ 2 METHOXY 4 [ 3 OXO 3 ( 8 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYLAMINO)PROP 1 ENYL]PHENOXY]ETHYL NITRIC ACID; 3 [ 2 METHOXY 4 [ 3 OXO 3 ( 2 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYLAMINO)PROP 1 ENYL]PHENOXY]PROPYL NITRIC ACID; 3 [ 2 METHOXY 4 [ 3 OXO 3 ( 3 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYLAMINO)PROP 1 ENYL]PHENOXY]PROPYL NITRIC ACID; 3 [ 2 METHOXY 4 [ 3 OXO 3 ( 4 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYLAMINO)PROP 1 ENYL]PHENOXY]PROPYL NITRIC ACID; 3 [ 2 METHOXY 4 [ 3 OXO 3 ( 6 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO)PROP 1 ENYL]PHENOXY]PROPYL NITRIC ACID; 3 [ 2 METHOXY 4 [ 3 OXO 3 ( 8 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYLAMINO)PROP 1 ENYL]PHENOXY]PROPYL NITRIC ACID; 4 [ 2 METHOXY 4 [ 3 OXO 3 ( 2 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYLAMINO)PROP 1 ENYL]PHENOXY]BUTYL NITRIC ACID; 4 [ 2 METHOXY 4 [ 3 OXO 3 ( 3 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYLAMINO)PROP 1 ENYL]PHENOXY]BUTYL NITRIC ACID; 4 [ 2 METHOXY 4 [ 3 OXO 3 ( 4 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYLAMINO)PROP 1 ENYL]PHENOXY]BUTYL NITRIC ACID; 4 [ 2 METHOXY 4 [ 3 OXO 3 ( 6 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO)PROP 1 ENYL]PHENOXY]BUTYL NITRIC ACID; 4 [ 2 METHOXY 4 [ 3 OXO 3 ( 8 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYLAMINO)PROP 1 ENYL]PHENOXY]BUTYL NITRIC ACID; 6 [ 2 METHOXY 4 [ 3 OXO 3 ( 2 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYLAMINO)PROP 1 ENYL]PHENOXY]HEXYL NITRIC ACID; 6 [ 2 METHOXY 4 [ 3 OXO 3 ( 3 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYLAMINO)PROP 1 ENYL]PHENOXY]HEXYL NITRIC ACID; 6 [ 2 METHOXY 4 [ 3 OXO 3 ( 4 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROP 1 ENYL]PHENOXY]HEXYL NITRIC ACID; 6 [ 2 METHOXY 4 [ 3 OXO 3 ( 6 ( 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO)PROP 1 ENYL]PHENOXY]HEXYL NITRIC ACID; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; FERULIC ACID; ISOSORBIDE DINITRATE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE DONOR; SCOPOLAMINE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLINESTERASE INHIBITION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; VASODILATATION;

ALZHEIMER DISEASE; ANIMALS; BEHAVIOR, ANIMAL; BINDING SITES; BIPHENYL COMPOUNDS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARIC ACIDS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; NITRIC OXIDE; NITRIC OXIDE DONORS; PICRATES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; VASODILATION;

EID: 84861048527     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300106z     Document Type: Article

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