Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 5885-5893

  Shan, Wen Jun ^a   Huang, Ling ^a   Zhou, Qi ^a   Meng, Fan Chao ^a   Li, Xing Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

9 N substituted berberine derivative; Acetylcholinesterase inhibitor; Alzheimer's disease; Amyloid aggregation inhibitory; Antioxidant properties

Indexed keywords

9 N (2 PHENYLETHYL)BERBERINE; 9 N (3 PHENYLPROPYL)BERBERINE; 9 N 2 PHENOXYETHYL BERBERINE; 9 N 3 PHENOXYPROPYL BERBERINE; 9 N 4 PHENOXYBUTYL BERBERINE; 9 N 5 PHENOXYPENTYL BERBERINE; 9 N 6 PHENOXYHEXYL BERBERINE; 9 N [2 (2 TOLYL)]ETHYLBERBERINE; 9 N [2 (2,4 DICHLOROPHENYL)]ETHYLBERBERINE; 9 N [2 (3 TOLYL)]ETHYLBERBERINE; 9 N [2 (3,4 DIMETHOXYPHENYL)]ETHYLBERBERINE; 9 N [2 (4 FLUOROPHENYL)]ETHYLBERBERINE; 9 N [2 (4 METHOXYPHENYL)]ETHYLBERBERINE; 9 N [2 (4 NITROPHENYL)]ETHYLBERBERINE; 9 N [2 (4 TOLYL)]ETHYLBERBERINE; 9 N [2 (5 METHOXY 1 H INDOL 3 YL)]ETHYLBERBERINE; 9 N [2 (PYRIDIN 2 YL)]ETHYLBERBERINE; 9 N [2 (THIOPHEN 2 YL)]ETHYLBERBERINE; 9 N [4 (NAPHTHALEN 1 YLOXY)BUTYL]BERBERINE; 9 N [4 (PYRIDIN 3 YLOXY)BUTYL]BERBERINE; 9 N BENZYLBERBERINE; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; BERBERINE; BERBERINE DERIVATIVE; CHOLINESTERASE INHIBITOR; CURCUMIN; TROLOX C; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; PROTEIN AGGREGATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BERBERINE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; HORSES; HUMANS; MODELS, MOLECULAR;

EID: 80955136609     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.051     Document Type: Article

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