Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 251-262

  Samadi, Abdelouahid ^a   De Los Ríos, Cristóbal ^b,c   Bolea, Irene ^d   Chioua, Mourad ^a   Iriepa, Isabel ^b   Moraleda, Ignacio ^b   Bartolini, Manuela ^e   Andrisano, Vincenza ^e   Gálvez, Enrique ^b   Valderas, Carolina ^a   Unzeta, Mercedes ^d   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Alzheimer's disease; Amyloid ; EeAChE; eqBuChE; Indoles; Inhibition mechanism; Kinetic analysis; MAO A; MAO B; Molecular modeling; Multipotent molecules; Naphthyridines

Indexed keywords

5 AMINO 7 (PROP 2 YN 1 YL) 6,7,8,9 TETRAHYDROPYRIDO[2,3 B][1,6]NAPHTHYRIDINE; ACETYLCHOLINESTERASE; ALKYL GROUP; AMINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; DONEPEZIL; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTEIN AGGREGATION; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BUTYRYLCHOLINESTERASE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; ELECTROPHORUS; HETEROCYCLIC COMPOUNDS; HUMANS; KINETICS; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PARGYLINE; PEPTIDE FRAGMENTS; PROPYLAMINES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RATS;

EID: 84860318738     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.022     Document Type: Article

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