Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 23-31

  Hamulakova, Slavka ^a   Janovec, Ladislav ^a   Hrabinova, Martina ^b   Kristian, Pavol ^a   Kuca, Kamil ^b,c   Banasova, Maria ^a   Imrich, Jan ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

AChE BChE inhibitors; Alzheimer's disease; Amyloid; Molecular modeling; Tacrine

Indexed keywords

3 (METHYLANILINO) 1 [4 [2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]PIPERAZINO] 1 PROPANONE; 3 (PIPERIDINO) 1 [4 [2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]PIPERAZIN] 1 PROPANONE; 3 [[2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]AMINO] 1 [4 [2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]PIPERAZINO] 1 PROPANONE; 3 [CYCLOHEXYL(METHYL)AMINO] 1 [4 [2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]PIPERAZINO] 1 PROPANONE; 3 CHLORO 1 [4 [2 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)ETHYL]PIPERAZINO] 1 PROPANONE; 7 METHOXY 9 AMINO 1,2,3,4 TETRAHYDROACRIDINE; ACETYLCHOLINESTERASE; CHOLINESTERASE; N [2 [4 [3 (METHYLANILINO)PROPYL]PIPERAZINO]ETHYL] (1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINE; N [2 [4 [3 (PIPERIDINOPROPYL)]PIPERAZINO]ETHYL] (1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINE; N [2 [4 [3 [CYCLOHEXYL(ETHYL)AMINO]PROPYL]PIPERAZINO]ETHYL] (1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINE; N [2 [4 [3 [CYCLOHEXYL(METHYL)AMINO]PROPYL]PIPERAZINO]ETHYL] (1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; PIPERAZINES; PROTEIN CONFORMATION; TACRINE;

EID: 84865770492     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.051     Document Type: Article

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