Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1244-1251

  Huang, Ling ^a   Shi, Anding ^a   He, Feng ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

AChE inhibitors; Berberine derivatives; Mix competitive binding mode

Indexed keywords

9 O [2 (9H CARBAZOL 4 YLOXY)ETHYL]BERBERINE BROMIDE; 9 O [2 (BENZOTRIAZOL 1 YLOXY)ETHYL]BERBERINE BROMIDE; 9 O [2 (PHENYLOL 1 YLOXY)ETHYL]BERBERINE BROMIDE; 9 O [2 (PHENYLOL 1 YLOXY)HEXYL]BERBERINE BROMIDE; 9 O [3 (9H CARBAZOL 4 YLOXY)PROPYL]BERBERINE BROMIDE; 9 O [3 (BENZOTRIAZOL 1 YLOXY)PROPYL]BERBERINE BROMIDE; 9 O [3 (PHENYLOL 1 XYLOXY)PROPYL]BERBERINE BROMIDE; 9 O [3 (PHENYLOL 1 YLOXY)PROPYL]BERBERINE BROMIDE; 9 O [4 (9H CARBAZOL 4 YLOXY)BUTYL]BERBERINE BROMIDE; 9 O [4 (BENZOTRIAZOL 1 YLOXY)BUTYL]BERBERINE BROMIDE; 9 O [4 (PHENYLOL 1 YLOXY)BUTYL]BERBERINE BROMIDE; 9 O [5 (9H CARBAZOL 4 YLOXY)BUTYL]BERBERINE BROMIDE; 9 O [5 (BENZOTRIAZOL 1 YLOXY)PENTYL]BERBERINE BROMIDE; 9 O [5 (PHENYLOL 1 YLOXY)PENTYL]BERBERINE BROMIDE; 9 O [6 (9H CARBAZOL 4 YLOXY)BUTYL]BERBERINE BROMIDE; 9 O [6 (BENZOTRIAZOL 1 YLOXY)HEXYL]BERBERINE BROMIDE; BERBERINE DERIVATIVE; CHOLINESTERASE INHIBITOR; GALANTAMINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR MODEL;

ACETYLCHOLINESTERASE; ANIMALS; BERBERINE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; EELS; HORSES; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 75149165246     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.035     Document Type: Article

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