Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1341-1348

  Belluti, Federica ^a   Piazzi, Lorna ^a   Bisi, Alessandra ^a   Gobbi, Silvia ^a   Bartolini, Manuela ^a   Cavalli, Andrea ^a   Valenti, Piero ^a   Rampa, Angela ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

AChE inhibitors; Alzheimer's disease; Benzophenone

Indexed keywords

(3,4 DIMETHOXYPHENYL) (4 MORPHOLIN 4 YLMETHYLPHENYL)METHANONE; (3,4 DIMETHOXYPHENYL) [4 (((2 METHOXYBENZYL)METHYLAMINO)METHYL)PHENYL] METHANONE; (3,4 DIMETHOXYPHENYL) [4 ((2 DIMETHYLAMINOETHYL)METHYLAMINO)METHYL)PHENYL]METHANONE; (3,4 DIMETHOXYPHENYL) [4 ((ETHYLPROPYLAMINO)METHYL)PHENYL]METHANONE; (3,4 DIMETHOXYPHENYL) [4 ((METHYL (3 METHYLBENZENE)AMINO)METHYL)PHENYL]METHANONE; (3,4 DIMETHOXYPHENYL) [4 ((METHYL (3 NITROBENZYL)AMINO)METHYL)PHENYL]METHANONE; (3,4 DIMETHOXYPHENYL) [4 ((METHYLPROP 2 YNYLAMINO)METHYL)PHENYL]METHANONE; [4 ((BENZYL (2 DIMETHYLAMINOETHYL)AMINO)METHYL) PHENYL] (3,4 DIMETHOXYPHENYL)METHANONE; [4 ((BENZYL (2 HYDROXYETHYL)AMINO)METHYL)PHENYL] (3,4 DIMETHOXYPHENYL)METHANONE; [4 ((BENZYLETHYLAMINO)METHYL)PHENYL] (3,4 DIMETHOXYPHENYL)METHANONE; [4 ((BENZYLMETHYLAMINO)METHYL)PHENYL] (3 FLUORO 4 METHOXYPHENYL)METHANONE; [4 ((BENZYLMETHYLAMINO)METHYL)PHENYL] (4 METHOXYPHENYL); [4 ((BENZYLMETHYLAMINO)METHYL)PHENYL]NAPHTHALEN 2 YL METHANONE; [4 (3 (BENZYLMETHYLAMINO)PROPENYL)PHENYL] (3,4 DIMETHOXYPHENYL)METHANONE; [4 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YLMETHYL)PHENYL] (3,4 DIMETHOXYPHENYL)METHANONE; [4-((BENZYLMETHYLAMINO)METHYL)PHENYL] (3,4-DIMETHOXYPHENYL)METHANONE; AMINE; BENZOPHENONE DERIVATIVE; CHOLINESTERASE INHIBITOR; DONEPEZIL; METHYLAMINE; N,N BENZYLMETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50;

ACETYLCHOLINESTERASE; BENZOPHENONES; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 60549106063     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.035     Document Type: Article

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