Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 6119-6130

  Martins, Carla ^a   Carreiras, M Carmo ^a   León, Rafael ^b,c   De Los Ríos, Cristóbal ^d,e   Bartolini, Manuela ^f   Andrisano, Vincenza ^f   Iriepa, Isabel ^d   Moraleda, Ignacio ^d   Gálvez, Enrique ^d   García, Manuela ^c,g   Egea, Javier ^c   Samadi, Abdelouhaid ^b   Chioua, Mourad ^b   Marco Contelles, José ^b  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c INSTITUTO TEÓFILO HERNANDO   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

Author keywords

AChE BuChE inhibitors; Alzheimer's disease; Neuroprotection

Indexed keywords

1 PHENYL 2 (P TOLYL) 5,6,7,8 TETRAHYDRO 1H PYRROLO(2,3 B)QUINOLIN 4 AMINE; 1,2 DIPHENYL 1,5,6,7,8,9 HEXAHYDROCYCLOHEPTA(B)PYRROLO(3,2 E)PYRIDIN 4 AMINE; 1,2 DIPHENYL 5,6,7,8 TETRAHYDRO 1H PYRROLO(2,3 B)QUINOLIN 4 AMINE; 2 (4 CHLOROPHENYL) 1 PHENYL 1,5,6,7,8,9 HEXAHYDROCYCLOHEPTA(B)PYRROLO(3,2 E)PYRIDIN 4 AMINE; 2 (4 CHLOROPHENYL) 1 PHENYL 5,6,7,8 TETRAHYDRO 1H PYRROLO(2,3 B)QUINOLIN 4 AMINE; 2 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLIN 4 AMINE; 2 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA(B)FURO(3,2 E)PYRIDIN 4 AMINE; 2 (P TOLYL) 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLIN 4 AMINE; 2 (P TOLYL) 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA(B)FURO(3,2 E)PYRIDIN 4 AMINE; 2 PHENYL 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLIN 4 AMINE; 2 PHENYL 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA(B)FURO(3,2 E)PYRIDIN 4 AMINE; 4 AMINO 2 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLINE 3 CARBONITRILE; 4 AMINO 2 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA(B)FURO(3,2 E)PYRIDINE 3 CARBONITRILE; 4 AMINO 2 (4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLINE 3 CARBONITRILE; 4 AMINO 2 (4 METHOXYPHENYL) 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA(B)FURO(3,2 E)PYRIDINE 3 CARBONITRILE; 4 AMINO 2 (P TOLYL) 5,6,7,8 TETRAHYDROFURO(2,3 B)QUINOLINE 3 CARBONITRILE; AMYLOID BETA PROTEIN[25-35]; CHOLINESTERASE; CYCLOALKANONE; NITRILE; QUINOLINE DERIVATIVE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CHEMICAL REACTION; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; SUBSTITUTION REACTION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOQUINOLINES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; MODELS, MOLECULAR; TACRINE;

EID: 80955140466     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.038     Document Type: Article

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