Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease

Journal of Biological Chemistry

Volumn 271, Issue 39, 1996, Pages 23646-23649

  Pang, Yuan Ping ^a   Quiram, Polly ^b   Jelacic, Tanya ^b   Hong, Feng ^a   Brimijoin, Stephen ^b  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; CHOLINESTERASE INHIBITOR; INSECTICIDE; TACRINE; TACRINE DERIVATIVE;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; COSTS AND COST ANALYSIS; DRUG DESIGN; KINETICS; LIGANDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

ANIMALIA;

EID: 0029817834     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.39.23646     Document Type: Article

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