Synthesis and evaluation of tacrine-huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 4, 1998, Pages 427-440

  Badia, Albert ^a   Baños, Josep E ^a   Camps, Pelayo ^b   Contreras, Joan ^b   Görbig, Diana M ^b   Muñoz Torrero, Diego ^b   Simón, Montserrat ^b   Vivas, Nuria M ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Friedlander reaction; Huperzine A related compounds; Tacrine related compounds

Indexed keywords

CHOLINESTERASE INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE; DONEPEZIL; HUPERZINE A; TACRINE; TACRINE DERIVATIVE; TUBOCURARINE CHLORIDE;

ANIMAL TISSUE; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEMIDIAPHRAGM; MALE; NEUROMUSCULAR BLOCKING; NEUROMUSCULAR SYNAPSE; NONHUMAN; PHRENIC NERVE; RACEMIC MIXTURE; RAT;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CATTLE; CHOLINESTERASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEUROMUSCULAR JUNCTION; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; SPECTROPHOTOMETRY, INFRARED; TACRINE;

ANIMALIA;

EID: 0032054003     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00015-7     Document Type: Article

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