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Volumn 52, Issue 4, 2013, Pages 333-355

the 11q13-q14 amplicon: Clinicopathological correlations and potential drivers

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ANTISENSE OLIGONUCLEOTIDE; CORTACTIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GRB2 ASSOCIATED BINDING PROTEIN; MESSENGER RNA; ORAL CANCER OVEREXPRESSED 1 PROTEIN; P21 ACTIVATED KINASE 1; PROTEIN; ROMIDEPSIN; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84873717467     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.22037     Document Type: Article
Times cited : (54)

References (241)
  • 1
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. 1998. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 273: 28238-28246.
    • (1998) J Biol Chem , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 2
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R. 2000. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275: 12041-12050.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 3
    • 0028891798 scopus 로고
    • Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1
    • Adelaide J, Monges G, Derderian C, Seitz JF, Birnbaum D. 1995. Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1. Br J Cancer 71: 64-68.
    • (1995) Br J Cancer , vol.71 , pp. 64-68
    • Adelaide, J.1    Monges, G.2    Derderian, C.3    Seitz, J.F.4    Birnbaum, D.5
  • 8
    • 0032997422 scopus 로고    scopus 로고
    • Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis in head and neck cancer
    • Alavi S, Namazie A, Calcaterra TC, Wang MB, Srivatsan ES. 1999. Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis in head and neck cancer. Laryngoscope 109: 874-879.
    • (1999) Laryngoscope , vol.109 , pp. 874-879
    • Alavi, S.1    Namazie, A.2    Calcaterra, T.C.3    Wang, M.B.4    Srivatsan, E.S.5
  • 9
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • Albertson DG. 2006. Gene amplification in cancer. Trends Genet 22: 447-455.
    • (2006) Trends Genet , vol.22 , pp. 447-455
    • Albertson, D.G.1
  • 10
    • 0024580245 scopus 로고
    • The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci
    • Ali IU, Merlo G, Callahan R, Lidereau R. 1989. The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci. Oncogene 4: 89-92.
    • (1989) Oncogene , vol.4 , pp. 89-92
    • Ali, I.U.1    Merlo, G.2    Callahan, R.3    Lidereau, R.4
  • 13
    • 77958155431 scopus 로고    scopus 로고
    • Using functional genetics to understand breast cancer biology
    • Ashworth A, Bernards R. 2010. Using functional genetics to understand breast cancer biology. Cold Spring Harb Perspect Biol 2: a003327.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Ashworth, A.1    Bernards, R.2
  • 14
    • 79953283356 scopus 로고    scopus 로고
    • Genetic interactions in cancer progression and treatment
    • Ashworth A, Lord CJ, Reis-Filho JS. 2011. Genetic interactions in cancer progression and treatment. Cell 145: 30-38.
    • (2011) Cell , vol.145 , pp. 30-38
    • Ashworth, A.1    Lord, C.J.2    Reis-Filho, J.S.3
  • 16
    • 0035880481 scopus 로고    scopus 로고
    • Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization
    • Balazs M, Adam Z, Treszl A, Begany A, Hunyadi J, Adany R. 2001. Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization. Cytometry 46: 222-232.
    • (2001) Cytometry , vol.46 , pp. 222-232
    • Balazs, M.1    Adam, Z.2    Treszl, A.3    Begany, A.4    Hunyadi, J.5    Adany, R.6
  • 17
    • 0030980877 scopus 로고    scopus 로고
    • Cyclin D1 in mammary carcinoma
    • Barnes DM. 1997. Cyclin D1 in mammary carcinoma. J Pathol 181: 267-269.
    • (1997) J Pathol , vol.181 , pp. 267-269
    • Barnes, D.M.1
  • 19
    • 0028894280 scopus 로고
    • Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer
    • Bartkova J, Lukas J, Muller H, Strauss M, Gusterson B, Bartek J. 1995. Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55: 949-956.
    • (1995) Cancer Res , vol.55 , pp. 949-956
    • Bartkova, J.1    Lukas, J.2    Muller, H.3    Strauss, M.4    Gusterson, B.5    Bartek, J.6
  • 20
    • 77955911553 scopus 로고    scopus 로고
    • Personalizing therapy for ovarian cancer: BRCAness and beyond
    • Bast RCJr., Mills GB. 2010. Personalizing therapy for ovarian cancer: BRCAness and beyond. J Clin Oncol 28: 3545-3548.
    • (2010) J Clin Oncol , vol.28 , pp. 3545-3548
    • Bast Jr., R.C.1    Mills, G.B.2
  • 21
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, Brocker EB, Pinkel D. 1998. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 58: 2170-2175.
    • (1998) Cancer Res , vol.58 , pp. 2170-2175
    • Bastian, B.C.1    LeBoit, P.E.2    Hamm, H.3    Brocker, E.B.4    Pinkel, D.5
  • 22
    • 0031593691 scopus 로고    scopus 로고
    • CCND1 and FGFR1 coamplification results in the colocalization of 11q13 and 8p12 sequences in breast tumor nuclei
    • Bautista S, Theillet C. 1998. CCND1 and FGFR1 coamplification results in the colocalization of 11q13 and 8p12 sequences in breast tumor nuclei. Genes Chromosomes Cancer 22: 268-277.
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 268-277
    • Bautista, S.1    Theillet, C.2
  • 28
    • 27744526076 scopus 로고    scopus 로고
    • Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer
    • Bhojani MS, Chen G, Ross BD, Beer DG, Rehemtulla A. 2005. Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. Cell Cycle 4: 1478-1481.
    • (2005) Cell Cycle , vol.4 , pp. 1478-1481
    • Bhojani, M.S.1    Chen, G.2    Ross, B.D.3    Beer, D.G.4    Rehemtulla, A.5
  • 29
    • 0037065939 scopus 로고    scopus 로고
    • Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays
    • Bieche I, Olivi M, Nogues C, Vidaud M, Lidereau R. 2002. Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays. Br J Cancer 86: 580-586.
    • (2002) Br J Cancer , vol.86 , pp. 580-586
    • Bieche, I.1    Olivi, M.2    Nogues, C.3    Vidaud, M.4    Lidereau, R.5
  • 30
    • 23844490779 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    • Biliran H, Jr., Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH, Liao JD. 2005. Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin Cancer Res 11: 6075-6086.
    • (2005) Clin Cancer Res , vol.11 , pp. 6075-6086
    • Biliran Jr., H.1    Wang, Y.2    Banerjee, S.3    Xu, H.4    Heng, H.5    Thakur, A.6    Bollig, A.7    Sarkar, F.H.8    Liao, J.D.9
  • 32
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM. 2003. Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 34
    • 0026057931 scopus 로고
    • Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis
    • Borg A, Sigurdsson H, Clark GM, Ferno M, Fuqua SA, Olsson H, Killander D, McGurie WL. 1991. Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis. Br J Cancer 63: 136-142.
    • (1991) Br J Cancer , vol.63 , pp. 136-142
    • Borg, A.1    Sigurdsson, H.2    Clark, G.M.3    Ferno, M.4    Fuqua, S.A.5    Olsson, H.6    Killander, D.7    McGurie, W.L.8
  • 35
    • 35549002845 scopus 로고    scopus 로고
    • Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer
    • Bostner J, Ahnstrom Waltersson M, Fornander T, Skoog L, Nordenskjold B, Stal O. 2007. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene 26: 6997-7005.
    • (2007) Oncogene , vol.26 , pp. 6997-7005
    • Bostner, J.1    Ahnstrom Waltersson, M.2    Fornander, T.3    Skoog, L.4    Nordenskjold, B.5    Stal, O.6
  • 36
    • 0029917008 scopus 로고    scopus 로고
    • Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification
    • Bringuier PP, Tamimi Y, Schuuring E, Schalken J. 1996. Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification. Oncogene 12: 1747-1753.
    • (1996) Oncogene , vol.12 , pp. 1747-1753
    • Bringuier, P.P.1    Tamimi, Y.2    Schuuring, E.3    Schalken, J.4
  • 40
  • 41
    • 33644850529 scopus 로고    scopus 로고
    • Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
    • Brummer T, Schramek D, Hayes VM, Bennett HL, Caldon CE, Musgrove EA, Daly RJ. 2006. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem 281: 626-637.
    • (2006) J Biol Chem , vol.281 , pp. 626-637
    • Brummer, T.1    Schramek, D.2    Hayes, V.M.3    Bennett, H.L.4    Caldon, C.E.5    Musgrove, E.A.6    Daly, R.J.7
  • 42
    • 33746524819 scopus 로고    scopus 로고
    • Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation
    • Burnworth B, Popp S, Stark HJ, Steinkraus V, Brocker EB, Hartschuh W, Birek C, Boukamp P. 2006. Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation. Oncogene 25: 4399-4412.
    • (2006) Oncogene , vol.25 , pp. 4399-4412
    • Burnworth, B.1    Popp, S.2    Stark, H.J.3    Steinkraus, V.4    Brocker, E.B.5    Hartschuh, W.6    Birek, C.7    Boukamp, P.8
  • 43
    • 25844515780 scopus 로고    scopus 로고
    • Downstream targets of growth factor and oestrogen signalling and endocrine resistance: The potential roles of c-Myc, cyclin D1 and cyclin E
    • Butt AJ, McNeil CM, Musgrove EA, Sutherland RL. 2005. Downstream targets of growth factor and oestrogen signalling and endocrine resistance: The potential roles of c-Myc, cyclin D1 and cyclin E. Endocr Relat Cancer 12( Suppl 1): S47-S59.
    • (2005) Endocr Relat Cancer , vol.12 , Issue.SUPPL 1
    • Butt, A.J.1    McNeil, C.M.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 44
    • 13844281018 scopus 로고    scopus 로고
    • Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays
    • Callagy G, Pharoah P, Chin SF, Sangan T, Daigo Y, Jackson L, Caldas C. 2005. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol 205: 388-396.
    • (2005) J Pathol , vol.205 , pp. 388-396
    • Callagy, G.1    Pharoah, P.2    Chin, S.F.3    Sangan, T.4    Daigo, Y.5    Jackson, L.6    Caldas, C.7
  • 45
    • 0029851750 scopus 로고    scopus 로고
    • Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines
    • Campbell DH, deFazio A, Sutherland RL, Daly RJ. 1996. Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines. Int J Cancer 68: 485-492.
    • (1996) Int J Cancer , vol.68 , pp. 485-492
    • Campbell, D.H.1    deFazio, A.2    Sutherland, R.L.3    Daly, R.J.4
  • 54
    • 4344583855 scopus 로고    scopus 로고
    • Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: Association with cyclin D1 amplification and survival
    • Chunder N, Mandal S, Roy A, Roychoudhury S, Panda CK. 2004. Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: Association with cyclin D1 amplification and survival. Diagn Mol Pathol 13: 172-182.
    • (2004) Diagn Mol Pathol , vol.13 , pp. 172-182
    • Chunder, N.1    Mandal, S.2    Roy, A.3    Roychoudhury, S.4    Panda, C.K.5
  • 55
    • 59649084693 scopus 로고    scopus 로고
    • Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon
    • Clark ES, Brown B, Whigham AS, Kochaishvili A, Yarbrough WG, Weaver AM. 2009. Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. Oncogene 28: 431-444.
    • (2009) Oncogene , vol.28 , pp. 431-444
    • Clark, E.S.1    Brown, B.2    Whigham, A.S.3    Kochaishvili, A.4    Yarbrough, W.G.5    Weaver, A.M.6
  • 56
    • 78649436372 scopus 로고    scopus 로고
    • BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation
    • Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. 2010. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal 3: ra84.
    • (2010) Sci Signal , vol.3
    • Corcoran, R.B.1    Dias-Santagata, D.2    Bergethon, K.3    Iafrate, A.J.4    Settleman, J.5    Engelman, J.A.6
  • 57
    • 0030863936 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification
    • Courjal F, Theillet C. 1997. Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification. Cancer Res 57: 4368-4377.
    • (1997) Cancer Res , vol.57 , pp. 4368-4377
    • Courjal, F.1    Theillet, C.2
  • 58
    • 0029848648 scopus 로고    scopus 로고
    • Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors
    • Courjal F, Louason G, Speiser P, Katsaros D, Zeillinger R, Theillet C. 1996. Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors. Int J Cancer 69: 247-253.
    • (1996) Int J Cancer , vol.69 , pp. 247-253
    • Courjal, F.1    Louason, G.2    Speiser, P.3    Katsaros, D.4    Zeillinger, R.5    Theillet, C.6
  • 60
    • 79957516181 scopus 로고    scopus 로고
    • EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: Implications for chromosomal instability/recombination syndromes as checkpoint diseases
    • Cousineau I, Belmaaza A. 2011. EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: Implications for chromosomal instability/recombination syndromes as checkpoint diseases. Mol Genet Genomics 285: 325-340.
    • (2011) Mol Genet Genomics , vol.285 , pp. 325-340
    • Cousineau, I.1    Belmaaza, A.2
  • 61
    • 77957832068 scopus 로고    scopus 로고
    • Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells
    • Croucher DR, Rickwood D, Tactacan CM, Musgrove EA, Daly RJ. 2010. Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol 30: 5057-5070.
    • (2010) Mol Cell Biol , vol.30 , pp. 5057-5070
    • Croucher, D.R.1    Rickwood, D.2    Tactacan, C.M.3    Musgrove, E.A.4    Daly, R.J.5
  • 62
    • 0034652452 scopus 로고    scopus 로고
    • Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
    • Cuny M, Kramar A, Courjal F, Johannsdottir V, Iacopetta B, Fontaine H, Grenier J, Culine S, Theillet C. 2000. Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations. Cancer Res 60: 1077-1083.
    • (2000) Cancer Res , vol.60 , pp. 1077-1083
    • Cuny, M.1    Kramar, A.2    Courjal, F.3    Johannsdottir, V.4    Iacopetta, B.5    Fontaine, H.6    Grenier, J.7    Culine, S.8    Theillet, C.9
  • 65
    • 4344674527 scopus 로고    scopus 로고
    • Cortactin signalling and dynamic actin networks
    • Daly RJ. 2004. Cortactin signalling and dynamic actin networks. Biochem J 382( Part 1): 13-25.
    • (2004) Biochem J , vol.382 , Issue.PART 1 , pp. 13-25
    • Daly, R.J.1
  • 66
    • 77954757207 scopus 로고    scopus 로고
    • Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure
    • Dean JL, Thangavel C, McClendon AK, Reed CA, Knudsen ES. 2010. Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure. Oncogene 29: 4018-4032.
    • (2010) Oncogene , vol.29 , pp. 4018-4032
    • Dean, J.L.1    Thangavel, C.2    McClendon, A.K.3    Reed, C.A.4    Knudsen, E.S.5
  • 68
    • 67650777303 scopus 로고    scopus 로고
    • Development of cell-cycle inhibitors for cancer therapy
    • Dickson MA, Schwartz GK. 2009. Development of cell-cycle inhibitors for cancer therapy. Curr Oncol 16: 36-43.
    • (2009) Curr Oncol , vol.16 , pp. 36-43
    • Dickson, M.A.1    Schwartz, G.K.2
  • 76
    • 0030969478 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
    • Gansauge S, Gansauge F, Ramadani M, Stobbe H, Rau B, Harada N, Beger HG. 1997. Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res 57: 1634-1637.
    • (1997) Cancer Res , vol.57 , pp. 1634-1637
    • Gansauge, S.1    Gansauge, F.2    Ramadani, M.3    Stobbe, H.4    Rau, B.5    Harada, N.6    Beger, H.G.7
  • 77
    • 65549170452 scopus 로고    scopus 로고
    • Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation
    • Garapaty S, Xu CF, Trojer P, Mahajan MA, Neubert TA, Samuels HH. 2009. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem 284: 7542-7552.
    • (2009) J Biol Chem , vol.284 , pp. 7542-7552
    • Garapaty, S.1    Xu, C.F.2    Trojer, P.3    Mahajan, M.A.4    Neubert, T.A.5    Samuels, H.H.6
  • 78
    • 85047699198 scopus 로고    scopus 로고
    • Nuclear transcription factor-kappaB as a target for cancer drug development
    • Garg A, Aggarwal BB. 2002. Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia 16: 1053-1068.
    • (2002) Leukemia , vol.16 , pp. 1053-1068
    • Garg, A.1    Aggarwal, B.B.2
  • 80
    • 0033795449 scopus 로고    scopus 로고
    • Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast
    • Geradts J, Ingram CD. 2000. Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast. Mod Pathol 13: 945-953.
    • (2000) Mod Pathol , vol.13 , pp. 945-953
    • Geradts, J.1    Ingram, C.D.2
  • 83
    • 33748556546 scopus 로고    scopus 로고
    • Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and uveal melanomas detected by fluorescence in situ hybridization
    • Glatz-Krieger K, Pache M, Tapia C, Fuchs A, Savic S, Glatz D, Mihatsch M, Meyer P. 2006. Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and uveal melanomas detected by fluorescence in situ hybridization. Virchows Arch 449: 328-333.
    • (2006) Virchows Arch , vol.449 , pp. 328-333
    • Glatz-Krieger, K.1    Pache, M.2    Tapia, C.3    Fuchs, A.4    Savic, S.5    Glatz, D.6    Mihatsch, M.7    Meyer, P.8
  • 84
    • 0035120289 scopus 로고    scopus 로고
    • Chromosomal alterations in squamous cell carcinomas of the head and neck: Window to the biology of disease
    • Gollin SM. 2001. Chromosomal alterations in squamous cell carcinomas of the head and neck: Window to the biology of disease. Head Neck 23: 238-253.
    • (2001) Head Neck , vol.23 , pp. 238-253
    • Gollin, S.M.1
  • 85
    • 33645278944 scopus 로고    scopus 로고
    • Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression
    • Grillo M, Bott MJ, Khandke N, McGinnis JP, Miranda M, Meyyappan M, Rosfjord EC, Rabindran SK. 2006. Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression. Breast Cancer Res Treat 95: 185-194.
    • (2006) Breast Cancer Res Treat , vol.95 , pp. 185-194
    • Grillo, M.1    Bott, M.J.2    Khandke, N.3    McGinnis, J.P.4    Miranda, M.5    Meyyappan, M.6    Rosfjord, E.C.7    Rabindran, S.K.8
  • 86
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 88
    • 27744463434 scopus 로고    scopus 로고
    • Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance
    • Hirokawa Y, Arnold M, Nakajima H, Zalcberg J, Maruta H. 2005. Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance. Cancer Biol Ther 4: 956-960.
    • (2005) Cancer Biol Ther , vol.4 , pp. 956-960
    • Hirokawa, Y.1    Arnold, M.2    Nakajima, H.3    Zalcberg, J.4    Maruta, H.5
  • 89
    • 40349116256 scopus 로고    scopus 로고
    • Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: Comparison with epidermal growth factor receptor status
    • Hofman P, Butori C, Havet K, Hofman V, Selva E, Guevara N, Santini J, Van Obberghen-Schilling E. 2008. Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: Comparison with epidermal growth factor receptor status. Br J Cancer 98: 956-964.
    • (2008) Br J Cancer , vol.98 , pp. 956-964
    • Hofman, P.1    Butori, C.2    Havet, K.3    Hofman, V.4    Selva, E.5    Guevara, N.6    Santini, J.7    Van Obberghen-Schilling, E.8
  • 91
    • 33646940460 scopus 로고    scopus 로고
    • Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
    • Holm C, Rayala S, Jirstrom K, Stal O, Kumar R, Landberg G. 2006. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst 98: 671-680.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 671-680
    • Holm, C.1    Rayala, S.2    Jirstrom, K.3    Stal, O.4    Kumar, R.5    Landberg, G.6
  • 95
    • 0030724968 scopus 로고    scopus 로고
    • EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer
    • Hui R, Campbell DH, Lee CS, McCaul K, Horsfall DJ, Musgrove EA, Daly RJ, Seshadri R, Sutherland RL. 1997. EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer. Oncogene 15: 1617-1623.
    • (1997) Oncogene , vol.15 , pp. 1617-1623
    • Hui, R.1    Campbell, D.H.2    Lee, C.S.3    McCaul, K.4    Horsfall, D.J.5    Musgrove, E.A.6    Daly, R.J.7    Seshadri, R.8    Sutherland, R.L.9
  • 98
    • 34347391035 scopus 로고    scopus 로고
    • Utilizing RNA interference to enhance cancer drug discovery
    • Iorns E, Lord CJ, Turner N, Ashworth A. 2007. Utilizing RNA interference to enhance cancer drug discovery. Nat Rev Drug Discov 6: 556-568.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 556-568
    • Iorns, E.1    Lord, C.J.2    Turner, N.3    Ashworth, A.4
  • 102
    • 0036376921 scopus 로고    scopus 로고
    • MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas
    • Janssen JW, Imoto I, Inoue J, Shimada Y, Ueda M, Imamura M, Bartram CR, Inazawa J. 2002b. MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. J Hum Genet 47: 460-464.
    • (2002) J Hum Genet , vol.47 , pp. 460-464
    • Janssen, J.W.1    Imoto, I.2    Inoue, J.3    Shimada, Y.4    Ueda, M.5    Imamura, M.6    Bartram, C.R.7    Inazawa, J.8
  • 103
    • 0026720446 scopus 로고
    • Amplification and expression of the human cyclin D gene in esophageal cancer
    • Jiang W, Kahn SM, Tomita N, Zhang YJ, Lu SH, Weinstein IB. 1992. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res 52: 2980-2983.
    • (1992) Cancer Res , vol.52 , pp. 2980-2983
    • Jiang, W.1    Kahn, S.M.2    Tomita, N.3    Zhang, Y.J.4    Lu, S.H.5    Weinstein, I.B.6
  • 104
    • 62449192609 scopus 로고    scopus 로고
    • [siRNA-cyclin D1 inhibit cell proliferation in breast cancer MCF-7 cell line]
    • Jiang L, Chen RS, Li JC. 2006. [siRNA-cyclin D1 inhibit cell proliferation in breast cancer MCF-7 cell line]. Fen Zi Xi Bao Sheng Wu Xue Bao 39: 118-122.
    • (2006) Fen Zi Xi Bao Sheng Wu Xue Bao , vol.39 , pp. 118-122
    • Jiang, L.1    Chen, R.S.2    Li, J.C.3
  • 105
    • 51949086479 scopus 로고    scopus 로고
    • Oral cancer overexpressed 1 (ORAOV1): A regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma
    • Jiang L, Zeng X, Yang H, Wang Z, Shen J, Bai J, Zhang Y, Gao F, Zhou M, Chen Q. 2008. Oral cancer overexpressed 1 (ORAOV1): A regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Int J Cancer 123: 1779-1786.
    • (2008) Int J Cancer , vol.123 , pp. 1779-1786
    • Jiang, L.1    Zeng, X.2    Yang, H.3    Wang, Z.4    Shen, J.5    Bai, J.6    Zhang, Y.7    Gao, F.8    Zhou, M.9    Chen, Q.10
  • 106
    • 77349126542 scopus 로고    scopus 로고
    • Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells
    • Jiang L, Zeng X, Wang Z, Ji N, Zhou Y, Liu X, Chen Q. 2010. Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells. Mol Cancer 9: 20.
    • (2010) Mol Cancer , vol.9 , pp. 20
    • Jiang, L.1    Zeng, X.2    Wang, Z.3    Ji, N.4    Zhou, Y.5    Liu, X.6    Chen, Q.7
  • 107
    • 24744449148 scopus 로고    scopus 로고
    • Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification
    • Jirstrom K, Stendahl M, Ryden L, Kronblad A, Bendahl PO, Stal O, Landberg G. 2005. Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification. Cancer Res 65: 8009-8016.
    • (2005) Cancer Res , vol.65 , pp. 8009-8016
    • Jirstrom, K.1    Stendahl, M.2    Ryden, L.3    Kronblad, A.4    Bendahl, P.O.5    Stal, O.6    Landberg, G.7
  • 109
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG, Jr. 2005. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 5: 689-698.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 110
    • 84855161432 scopus 로고    scopus 로고
    • ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma
    • Kang JU, Koo SH. 2012. ORAOV1 is a probable target within the 11q13.3 amplicon in lymph node metastases from gastric adenocarcinoma. Int J Mol Med 29: 81-87.
    • (2012) Int J Mol Med , vol.29 , pp. 81-87
    • Kang, J.U.1    Koo, S.H.2
  • 111
    • 33745686009 scopus 로고    scopus 로고
    • RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes
    • Kao J, Pollack JR. 2006. RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes. Genes Chromosomes Cancer 45: 761-769.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 761-769
    • Kao, J.1    Pollack, J.R.2
  • 113
    • 80051558985 scopus 로고    scopus 로고
    • High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1
    • Karlsson E, Waltersson MA, Bostner J, Perez-Tenorio G, Olsson B, Hallbeck AL, Stal O. 2011. High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer 50: 775-787.
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 775-787
    • Karlsson, E.1    Waltersson, M.A.2    Bostner, J.3    Perez-Tenorio, G.4    Olsson, B.5    Hallbeck, A.L.6    Stal, O.7
  • 117
    • 33745591122 scopus 로고    scopus 로고
    • TAOS1, a novel marker for advanced esophageal squamous cell carcinoma
    • Komatsu Y, Hibi K, Kodera Y, Akiyama S, Ito K, Nakao A. 2006. TAOS1, a novel marker for advanced esophageal squamous cell carcinoma. Anticancer Res 26: 2029-2032.
    • (2006) Anticancer Res , vol.26 , pp. 2029-2032
    • Komatsu, Y.1    Hibi, K.2    Kodera, Y.3    Akiyama, S.4    Ito, K.5    Nakao, A.6
  • 119
    • 84855662114 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 by shRNA is associated with enhanced sensitivity to conventional therapies for head and neck squamous cell carcinoma
    • Kothari V, Mulherkar R. 2012. Inhibition of cyclin D1 by shRNA is associated with enhanced sensitivity to conventional therapies for head and neck squamous cell carcinoma. Anticancer Res 32: 121-128.
    • (2012) Anticancer Res , vol.32 , pp. 121-128
    • Kothari, V.1    Mulherkar, R.2
  • 120
    • 2442675495 scopus 로고    scopus 로고
    • Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
    • Koziczak M, Holbro T, Hynes NE. 2004. Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins. Oncogene 23: 3501-3508.
    • (2004) Oncogene , vol.23 , pp. 3501-3508
    • Koziczak, M.1    Holbro, T.2    Hynes, N.E.3
  • 122
  • 124
    • 70349655707 scopus 로고    scopus 로고
    • Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma
    • Lazar V, Ecsedi S, Szollosi AG, Toth R, Vizkeleti L, Rakosy Z, Begany A, Adany R, Balazs M. 2009. Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma. Mod Pathol 22: 1367-1378.
    • (2009) Mod Pathol , vol.22 , pp. 1367-1378
    • Lazar, V.1    Ecsedi, S.2    Szollosi, A.G.3    Toth, R.4    Vizkeleti, L.5    Rakosy, Z.6    Begany, A.7    Adany, R.8    Balazs, M.9
  • 125
    • 33749657631 scopus 로고    scopus 로고
    • Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human
    • Lee YM, Sicinski P. 2006. Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human. Cell Cycle 5: 2110-2114.
    • (2006) Cell Cycle , vol.5 , pp. 2110-2114
    • Lee, Y.M.1    Sicinski, P.2
  • 127
    • 78650224628 scopus 로고    scopus 로고
    • Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features
    • Lehn S, Tobin NP, Berglund P, Nilsson K, Sims AH, Jirstrom K, Harkonen P, Lamb R, Landberg G. 2010. Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features. Am J Pathol 177: 2886-2897.
    • (2010) Am J Pathol , vol.177 , pp. 2886-2897
    • Lehn, S.1    Tobin, N.P.2    Berglund, P.3    Nilsson, K.4    Sims, A.H.5    Jirstrom, K.6    Harkonen, P.7    Lamb, R.8    Landberg, G.9
  • 134
    • 70350714440 scopus 로고    scopus 로고
    • Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1
    • Liu F, Li X, Wang C, Cai X, Du Z, Xu H, Li F. 2009a. Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1. Int J Cancer 125: 2511-2519.
    • (2009) Int J Cancer , vol.125 , pp. 2511-2519
    • Liu, F.1    Li, X.2    Wang, C.3    Cai, X.4    Du, Z.5    Xu, H.6    Li, F.7
  • 135
    • 70449522183 scopus 로고    scopus 로고
    • Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers
    • Liu HS, Lu HH, Lui MT, Yu EH, Shen W, Chen YP, Chang KW, Tu HF. 2009b. Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers. Oral Oncol 45: 1032-1036.
    • (2009) Oral Oncol , vol.45 , pp. 1032-1036
    • Liu, H.S.1    Lu, H.H.2    Lui, M.T.3    Yu, E.H.4    Shen, W.5    Chen, Y.P.6    Chang, K.W.7    Tu, H.F.8
  • 136
    • 0029910364 scopus 로고    scopus 로고
    • Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint
    • Lukas J, Bartkova J, Bartek J. 1996. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol 16: 6917-6925.
    • (1996) Mol Cell Biol , vol.16 , pp. 6917-6925
    • Lukas, J.1    Bartkova, J.2    Bartek, J.3
  • 137
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 18: 753-761.
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 138
    • 59449085778 scopus 로고    scopus 로고
    • Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
    • Lundgren K, Holm K, Nordenskjold B, Borg A, Landberg G. 2008. Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. Breast Cancer Res 10: R81.
    • (2008) Breast Cancer Res , vol.10
    • Lundgren, K.1    Holm, K.2    Nordenskjold, B.3    Borg, A.4    Landberg, G.5
  • 139
    • 33846225205 scopus 로고    scopus 로고
    • Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance
    • Luo ML, Shen XM, Zhang Y, Wei F, Xu X, Cai Y, Zhang X, Sun YT, Zhan QM, Wu M, Wang MR. 2006. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res 66: 11690-11699.
    • (2006) Cancer Res , vol.66 , pp. 11690-11699
    • Luo, M.L.1    Shen, X.M.2    Zhang, Y.3    Wei, F.4    Xu, X.5    Cai, Y.6    Zhang, X.7    Sun, Y.T.8    Zhan, Q.M.9    Wu, M.10    Wang, M.R.11
  • 140
    • 0038498066 scopus 로고    scopus 로고
    • A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton
    • Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ. 2003. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem 278: 21805-21813.
    • (2003) J Biol Chem , vol.278 , pp. 21805-21813
    • Lynch, D.K.1    Winata, S.C.2    Lyons, R.J.3    Hughes, W.E.4    Lehrbach, G.M.5    Wasinger, V.6    Corthals, G.7    Cordwell, S.8    Daly, R.J.9
  • 146
    • 23244467708 scopus 로고    scopus 로고
    • Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
    • Menard RE, Jovanovski AP, Mattingly RR. 2005. Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis. Neoplasia 7: 638-645.
    • (2005) Neoplasia , vol.7 , pp. 638-645
    • Menard, R.E.1    Jovanovski, A.P.2    Mattingly, R.R.3
  • 149
    • 72449164413 scopus 로고    scopus 로고
    • The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer
    • Mira A, Isella C, Renzulli T, Cantarella D, Martelli ML, Medico E. 2009. The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer. Oncogene 28: 4444-4455.
    • (2009) Oncogene , vol.28 , pp. 4444-4455
    • Mira, A.1    Isella, C.2    Renzulli, T.3    Cantarella, D.4    Martelli, M.L.5    Medico, E.6
  • 150
    • 79751528964 scopus 로고    scopus 로고
    • Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
    • Modi H, Li L, Chu S, Rossi J, Yee JK, Bhatia R. 2011. Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia 25: 305-312.
    • (2011) Leukemia , vol.25 , pp. 305-312
    • Modi, H.1    Li, L.2    Chu, S.3    Rossi, J.4    Yee, J.K.5    Bhatia, R.6
  • 153
  • 156
    • 79955765689 scopus 로고    scopus 로고
    • Next-generation sequencing applied to molecular diagnostics
    • Natrajan R, Reis-Filho JS. 2011. Next-generation sequencing applied to molecular diagnostics. Expert Rev Mol Diagn 11: 425-444.
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 425-444
    • Natrajan, R.1    Reis-Filho, J.S.2
  • 160
    • 0032472916 scopus 로고    scopus 로고
    • A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
    • Newton K, Harris AW, Bath ML, Smith KG, Strasser A. 1998. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 17: 706-718.
    • (1998) EMBO J , vol.17 , pp. 706-718
    • Newton, K.1    Harris, A.W.2    Bath, M.L.3    Smith, K.G.4    Strasser, A.5
  • 164
    • 0032566062 scopus 로고    scopus 로고
    • Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro
    • Patel AS, Schechter GL, Wasilenko WJ, Somers KD. 1998. Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro. Oncogene 16: 3227-3232.
    • (1998) Oncogene , vol.16 , pp. 3227-3232
    • Patel, A.S.1    Schechter, G.L.2    Wasilenko, W.J.3    Somers, K.D.4
  • 168
    • 79953055826 scopus 로고    scopus 로고
    • Growth of chronic myeloid leukemia cells is inhibited by infection with Ad-SH2-HA adenovirus that disrupts Grb2-Bcr-Abl complexes
    • Peng Z, Luo HW, Yuan Y, Shi J, Huang SF, Li CL, Cao WX, Huang ZG, Feng WL. 2011. Growth of chronic myeloid leukemia cells is inhibited by infection with Ad-SH2-HA adenovirus that disrupts Grb2-Bcr-Abl complexes. Oncol Rep 25: 1381-1388.
    • (2011) Oncol Rep , vol.25 , pp. 1381-1388
    • Peng, Z.1    Luo, H.W.2    Yuan, Y.3    Shi, J.4    Huang, S.F.5    Li, C.L.6    Cao, W.X.7    Huang, Z.G.8    Feng, W.L.9
  • 170
    • 0031877301 scopus 로고    scopus 로고
    • c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry
    • Prall OW, Rogan EM, Musgrove EA, Watts CK, Sutherland RL. 1998. c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol 18: 4499-4508.
    • (1998) Mol Cell Biol , vol.18 , pp. 4499-4508
    • Prall, O.W.1    Rogan, E.M.2    Musgrove, E.A.3    Watts, C.K.4    Sutherland, R.L.5
  • 172
    • 24744443338 scopus 로고    scopus 로고
    • Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY
    • Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, Eaves CJ. 2005. Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. J Natl Cancer Inst 97: 1302-1306.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1302-1306
    • Raouf, A.1    Brown, L.2    Vrcelj, N.3    To, K.4    Kwok, W.5    Huntsman, D.6    Eaves, C.J.7
  • 173
    • 81555216077 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: Classification, prognostication, and prediction
    • Reis-Filho JS, Pusztai L. 2011. Gene expression profiling in breast cancer: Classification, prognostication, and prediction. Lancet 378: 1812-1823.
    • (2011) Lancet , vol.378 , pp. 1812-1823
    • Reis-Filho, J.S.1    Pusztai, L.2
  • 174
    • 33745190482 scopus 로고    scopus 로고
    • Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: An immunohistochemical and chromogenic in situ hybridisation analysis
    • Reis-Filho JS, Savage K, Lambros MB, James M, Steele D, Jones RL, Dowsett M. 2006a. Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: An immunohistochemical and chromogenic in situ hybridisation analysis. Mod Pathol 19: 999-1009.
    • (2006) Mod Pathol , vol.19 , pp. 999-1009
    • Reis-Filho, J.S.1    Savage, K.2    Lambros, M.B.3    James, M.4    Steele, D.5    Jones, R.L.6    Dowsett, M.7
  • 176
    • 0033870355 scopus 로고    scopus 로고
    • EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck
    • Rodrigo JP, Garcia LA, Ramos S, Lazo PS, Suarez C. 2000. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin Cancer Res 6: 3177-3182.
    • (2000) Clin Cancer Res , vol.6 , pp. 3177-3182
    • Rodrigo, J.P.1    Garcia, L.A.2    Ramos, S.3    Lazo, P.S.4    Suarez, C.5
  • 179
    • 0033848878 scopus 로고    scopus 로고
    • Integrating the MAP kinase signal into the G1 phase cell cycle machinery
    • Roovers K, Assoian RK. 2000. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22: 818-826.
    • (2000) Bioessays , vol.22 , pp. 818-826
    • Roovers, K.1    Assoian, R.K.2
  • 181
    • 77953697676 scopus 로고    scopus 로고
    • High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer
    • Roy PG, Pratt N, Purdie CA, Baker L, Ashfield A, Quinlan P, Thompson AM. 2010. High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer. Int J Cancer 127: 355-360.
    • (2010) Int J Cancer , vol.127 , pp. 355-360
    • Roy, P.G.1    Pratt, N.2    Purdie, C.A.3    Baker, L.4    Ashfield, A.5    Quinlan, P.6    Thompson, A.M.7
  • 184
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, King W, Wilber K, Mihatsch MJ, Moch H. 2003. Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 163: 985-992.
    • (2003) Am J Pathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5    Ruffalo, T.6    King, W.7    Wilber, K.8    Mihatsch, M.J.9    Moch, H.10
  • 185
    • 0029043876 scopus 로고
    • The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review
    • Schuuring E. 1995. The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review. Gene 159: 83-96.
    • (1995) Gene , vol.159 , pp. 83-96
    • Schuuring, E.1
  • 187
    • 0032104542 scopus 로고    scopus 로고
    • Amplification of oncogenes in human cancer cells
    • Schwab M. 1998. Amplification of oncogenes in human cancer cells. Bioessays 20: 473-479.
    • (1998) Bioessays , vol.20 , pp. 473-479
    • Schwab, M.1
  • 189
    • 0029657594 scopus 로고    scopus 로고
    • Cyclin DI amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis
    • Seshadri R, Lee CS, Hui R, McCaul K, Horsfall DJ, Sutherland RL. 1996. Cyclin DI amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis. Clin Cancer Res 2: 1177-1184.
    • (1996) Clin Cancer Res , vol.2 , pp. 1177-1184
    • Seshadri, R.1    Lee, C.S.2    Hui, R.3    McCaul, K.4    Horsfall, D.J.5    Sutherland, R.L.6
  • 190
    • 70449105984 scopus 로고    scopus 로고
    • Suppression of cancer cell growth by promoting cyclin D1 degradation
    • Shan J, Zhao W, Gu W. 2009. Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell 36: 469-476.
    • (2009) Mol Cell , vol.36 , pp. 469-476
    • Shan, J.1    Zhao, W.2    Gu, W.3
  • 197
    • 2942533005 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients
    • Stendahl M, Kronblad A, Ryden L, Emdin S, Bengtsson NO, Landberg G. 2004. Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients. Br J Cancer 90: 1942-1948.
    • (2004) Br J Cancer , vol.90 , pp. 1942-1948
    • Stendahl, M.1    Kronblad, A.2    Ryden, L.3    Emdin, S.4    Bengtsson, N.O.5    Landberg, G.6
  • 201
    • 79960864501 scopus 로고    scopus 로고
    • Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma
    • Sugahara K, Michikawa Y, Ishikawa K, Shoji Y, Iwakawa M, Shibahara T, Imai T. 2011. Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma. Int J Oncol 39: 761-769.
    • (2011) Int J Oncol , vol.39 , pp. 761-769
    • Sugahara, K.1    Michikawa, Y.2    Ishikawa, K.3    Shoji, Y.4    Iwakawa, M.5    Shibahara, T.6    Imai, T.7
  • 202
    • 0032846412 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in invasive breast cancers: Correlation with cyclin-dependent kinase 4 and oestrogen receptor overexpression, and lack of correlation with mitotic activity
    • Takano Y, Takenaka H, Kato Y, Masuda M, Mikami T, Saegusa M, Okayasu I. 1999. Cyclin D1 overexpression in invasive breast cancers: Correlation with cyclin-dependent kinase 4 and oestrogen receptor overexpression, and lack of correlation with mitotic activity. J Cancer Res Clin Oncol 125: 505-512.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 505-512
    • Takano, Y.1    Takenaka, H.2    Kato, Y.3    Masuda, M.4    Mikami, T.5    Saegusa, M.6    Okayasu, I.7
  • 205
    • 0028128954 scopus 로고
    • Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: Association with Cdk4 is required for Cyclin D1 function in G1 progression
    • Tam SW, Theodoras AM, Shay JW, Draetta GF, Pagano M. 1994. Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: Association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene 9: 2663-2674.
    • (1994) Oncogene , vol.9 , pp. 2663-2674
    • Tam, S.W.1    Theodoras, A.M.2    Shay, J.W.3    Draetta, G.F.4    Pagano, M.5
  • 206
    • 0037439789 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway
    • Tashiro E, Maruki H, Minato Y, Doki Y, Weinstein IB, Imoto M. 2003. Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway. Cancer Res 63: 424-431.
    • (2003) Cancer Res , vol.63 , pp. 424-431
    • Tashiro, E.1    Maruki, H.2    Minato, Y.3    Doki, Y.4    Weinstein, I.B.5    Imoto, M.6
  • 207
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu O, McCormick F. 2003. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3: 233-245.
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1    McCormick, F.2
  • 209
    • 0038393124 scopus 로고    scopus 로고
    • The death effector domain protein family: Regulators of cellular homeostasis
    • Tibbetts MD, Zheng L, Lenardo MJ. 2003. The death effector domain protein family: Regulators of cellular homeostasis. Nat Immunol 4: 404-409.
    • (2003) Nat Immunol , vol.4 , pp. 404-409
    • Tibbetts, M.D.1    Zheng, L.2    Lenardo, M.J.3
  • 210
    • 17144399942 scopus 로고    scopus 로고
    • Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor
    • Timpson P, Lynch DK, Schramek D, Walker F, Daly RJ. 2005. Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Cancer Res 65: 3273-3280.
    • (2005) Cancer Res , vol.65 , pp. 3273-3280
    • Timpson, P.1    Lynch, D.K.2    Schramek, D.3    Walker, F.4    Daly, R.J.5
  • 211
    • 35148821848 scopus 로고    scopus 로고
    • Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib
    • Timpson P, Wilson AS, Lehrbach GM, Sutherland RL, Musgrove EA, Daly RJ. 2007. Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res 67: 9304-9314.
    • (2007) Cancer Res , vol.67 , pp. 9304-9314
    • Timpson, P.1    Wilson, A.S.2    Lehrbach, G.M.3    Sutherland, R.L.4    Musgrove, E.A.5    Daly, R.J.6
  • 212
    • 77954620472 scopus 로고    scopus 로고
    • FADD: A regulator of life and death
    • Tourneur L, Chiocchia G. 2010. FADD: A regulator of life and death. Trends Immunol 31: 260-269.
    • (2010) Trends Immunol , vol.31 , pp. 260-269
    • Tourneur, L.1    Chiocchia, G.2
  • 214
    • 0024463790 scopus 로고
    • High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas
    • Tsuda T, Tahara E, Kajiyama G, Sakamoto H, Terada M, Sugimura T. 1989b. High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas. Cancer Res 49: 5505-5508.
    • (1989) Cancer Res , vol.49 , pp. 5505-5508
    • Tsuda, T.1    Tahara, E.2    Kajiyama, G.3    Sakamoto, H.4    Terada, M.5    Sugimura, T.6
  • 217
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R. 2000. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275: 36238-36244.
    • (2000) J Biol Chem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5    Sahin, A.6    Chernoff, J.7    Hung, M.C.8    Kumar, R.9
  • 219
    • 0022962654 scopus 로고
    • Biochemical mechanisms of oncogene activity: Proteins encoded by oncogenes. Introduction
    • Varmus H, Bishop JM. 1986. Biochemical mechanisms of oncogene activity: Proteins encoded by oncogenes. Introduction. Cancer Surv 5: 153-158.
    • (1986) Cancer Surv , vol.5 , pp. 153-158
    • Varmus, H.1    Bishop, J.M.2
  • 220
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. 2002. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 222
    • 33646682385 scopus 로고    scopus 로고
    • PAK1 hyperactivation is sufficient for mammary gland tumor formation
    • Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. 2006. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 25: 2931-2936.
    • (2006) Oncogene , vol.25 , pp. 2931-2936
    • Wang, R.A.1    Zhang, H.2    Balasenthil, S.3    Medina, D.4    Kumar, R.5
  • 223
    • 44149091903 scopus 로고    scopus 로고
    • Cortactin in tumor invasiveness
    • Weaver AM. 2008. Cortactin in tumor invasiveness. Cancer Lett 265: 157-166.
    • (2008) Cancer Lett , vol.265 , pp. 157-166
    • Weaver, A.M.1
  • 225
    • 0029797695 scopus 로고    scopus 로고
    • The molecular basis of carcinogenesis: Understanding the cell cycle clock
    • Weinberg RA. 1996. The molecular basis of carcinogenesis: Understanding the cell cycle clock. Cytokines Mol Ther 2: 105-110.
    • (1996) Cytokines Mol Ther , vol.2 , pp. 105-110
    • Weinberg, R.A.1
  • 226
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy
    • Weinstein IB, Joe AK. 2006. Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 3: 448-457.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 227
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • discussion 3080.
    • Weinstein IB, Joe A. 2008. Oncogene addiction. Cancer Res 68: 3077-3080; discussion 3080.
    • (2008) Cancer Res , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 228
    • 0030964233 scopus 로고    scopus 로고
    • Inducible overexpression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogens
    • Wilcken NR, Prall OW, Musgrove EA, Sutherland RL. 1997. Inducible overexpression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogens. Clin Cancer Res 3: 849-854.
    • (1997) Clin Cancer Res , vol.3 , pp. 849-854
    • Wilcken, N.R.1    Prall, O.W.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 231
    • 77955599451 scopus 로고    scopus 로고
    • Function, regulation and pathological roles of the Gab/DOS docking proteins
    • Wohrle FU, Daly RJ, Brummer T. 2009. Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal 7: 22.
    • (2009) Cell Commun Signal , vol.7 , pp. 22
    • Wohrle, F.U.1    Daly, R.J.2    Brummer, T.3
  • 234
    • 77954216859 scopus 로고    scopus 로고
    • Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer
    • Yi C, Maksimoska J, Marmorstein R, Kissil JL. 2010. Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. Biochem Pharmacol 80: 683-689.
    • (2010) Biochem Pharmacol , vol.80 , pp. 683-689
    • Yi, C.1    Maksimoska, J.2    Marmorstein, R.3    Kissil, J.L.4
  • 235
    • 0037318729 scopus 로고    scopus 로고
    • Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma
    • Yuan BZ, Zhou X, Zimonjic DB, Durkin ME, Popescu NC. 2003. Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma. J Mol Diagn 5: 48-53.
    • (2003) J Mol Diagn , vol.5 , pp. 48-53
    • Yuan, B.Z.1    Zhou, X.2    Zimonjic, D.B.3    Durkin, M.E.4    Popescu, N.C.5
  • 237
    • 0032546387 scopus 로고    scopus 로고
    • Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
    • Zhang J, Cado D, Chen A, Kabra NH, Winoto A. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392: 296-300.
    • (1998) Nature , vol.392 , pp. 296-300
    • Zhang, J.1    Cado, D.2    Chen, A.3    Kabra, N.H.4    Winoto, A.5
  • 238
    • 0035839640 scopus 로고    scopus 로고
    • FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery
    • Zhang J, Kabra NH, Cado D, Kang C, Winoto A. 2001. FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. J Biol Chem 276: 29815-29818.
    • (2001) J Biol Chem , vol.276 , pp. 29815-29818
    • Zhang, J.1    Kabra, N.H.2    Cado, D.3    Kang, C.4    Winoto, A.5
  • 239
    • 9444233897 scopus 로고    scopus 로고
    • FADD and its phosphorylation
    • Zhang J, Zhang D, Hua Z. 2004. FADD and its phosphorylation. IUBMB Life 56: 395-401.
    • (2004) IUBMB Life , vol.56 , pp. 395-401
    • Zhang, J.1    Zhang, D.2    Hua, Z.3
  • 240
    • 0024583686 scopus 로고
    • Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease
    • Zhou DJ, Ahuja H, Cline MJ. 1989. Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease. Oncogene 4: 105-108.
    • (1989) Oncogene , vol.4 , pp. 105-108
    • Zhou, D.J.1    Ahuja, H.2    Cline, M.J.3


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