Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance

Cancer Research

Volumn 66, Issue 24, 2006, Pages 11690-11699

  Luo, Man Li ^a   Shen, Xiao Ming ^a   Zhang, Yu ^a   Wei, Fang ^a   Xu, Xin ^a   Cai, Yan ^a   Zhang, Xun ^a   Sun, Yun Tian ^a   Zhan, Qi Min ^a   Wu, Min ^a   Wang, Ming Rong ^a  

^a CANCER HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CORTACTIN; MESSENGER RNA; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOIKIS; ARTICLE; CANCER GROWTH; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

ANOIKIS; CARCINOMA, SQUAMOUS CELL; CELL MOVEMENT; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; CORTACTIN; DNA PRIMERS; ESOPHAGEAL NEOPLASMS; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM;

EID: 33846225205     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1484     Document Type: Article

References (44)

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001;2:533-43.
2. Wei F, Ni J, Wu SS, et al. Cytogenetic studies of esophageal squamous cell carcinomas in the northern Chinese population by comparative genomic hybridization. Cancer Genet Cytogenet 2002;138:38-43.
3. Tada K, Oka M, Tangoku A, Hayashi H, Oga A, Sasaki K. Gains of 8q23-qter and 20q and loss of 11q22-qter in esophageal squamous cell carcinoma associated with lymph node metastasis. Cancer 2000;88:268-73.
4. Ishizuka T, Tanabe C, Sakamoto H, et al. Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH. Biochem Biophys Res Commun 2002;296:152-5.
5. Schuuring E. The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes-a review. Gene 1995;159:83-96.
6. Jiang W, Zhang YJ, Kahn SM, et al. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci U S A 1993;90:9026-30.
7. Naitoh H, Shibata J, Kawaguchi A, Kodama M, Hattori T. Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer. Am J Pathol 1995;146:1161-9.
8. Inomata M, Uchino S, Tanimura H, Shiraishi N, Adachi Y, Kitano S. Amplification and overexpression of cyclin D1 in aggressive human esophageal cancer. Oncol Rep 1998;5:171-6.
9. Suzuki H, Moriya J, Nakahata A, Fujioka Y, Inoue K, Nagashima K. Cyclin D1 gene amplification in esophageal carcinosarcoma shown by differential polymerase chain reaction. Hum Pathol 1998;29:662-7.
10. Watanabe M, Kuwano H, Tanaka S, Toh Y, Masuda H, Sugimachi K. A significant morphological transformation is recognized in human esophageal cancer cells with an amplification/overexpression of the cyclin D1 gene. Int J Oncol 1999;15:1103-8.
11. Lu F, Gladden AB, Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 2003;63:7056-61.
12. Arai H, Ueno T, Tangoku A, et al. Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma: comparison with conventional comparative genomic hybridization analysis. Cancer Genet Cytogenet 2003;146:16-21.
13. Weed SA, Parsons JT. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene 2001;20:6418-34.
14. Daly RJ. Cortactin signalling and dynamic actin networks. Biochem J 2004;382:13-25.
15. Freier K, Sticht C, Hofele C, et al. Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma. Genes Chromosomes Cancer 2006;45:118-25.
16. Xiao-Ping H, Tie-Hua R, Peng L, et al. Cyclin D1 overexpression in esophageal cancer from southern China and its clinical significance. Cancer Lett 2006;231:94-101.
17. Bringuier PP, Tamimi Y, Schuuring E, Schalken J. Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification. Oncogene 1996;12:1747-53.
18. Fantl V, Smith R, Brookes S, Dickson C, Peters G. Chromosome 11q13 abnormalities in human breast cancer. Cancer Surv 1993;18:77-94.
19. Rothschild BL, Shim AH, Ammer AG, et al. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res 2006;66:8017-25.
20. Zhu J, Zhou K, Hao JJ, Liu J, Smith N, Zhan X. Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits. J Cell Sci 2005;118:807-17.
21. Han Y, Wei F, Xu X, et al. [Establishment and comparative genomic hybridization analysis of human esophageal carcinomas cell line EC9706]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002;19:455-7.
22. Li Y, Tondravi M, Liu J, et al. Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res 2001;61:6906-11.
23. Bourguignon LY, Zhu H, Shao L, Chen YW. CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem 2001;276:7327-36.
24. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol 2001;13:555-62.
25. Terada M, Sakamoto H, Ohmura Y, et al. Biological significance of gene amplification in carcinogenesis. Princess Takamatsu Symp 1991;22:371-80.
26. Mon M, Tokino T, Yanagisawa A, Kanamori M, Kato Y, Nakamura Y. Association between chromosome Ilql3 amplification and prognosis of patients with oesophageal carcinomas. Eur J Cancer 1992;28A:755-7.
27. Schuuring E, Verhoeven E, van Tinteren H, et al. Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer. Cancer Res 1992;52:5229-34.
28. Rodrigo JP, Garcia LA, Ramos S, Lazo PS, Suarez C. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin Cancer Res 2000;6:3177-82.
29. Takes RP, Baatenburg de Jong RJ, Schuuring E, et al. Markers for assessment of nodal metastasis in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 1997;123:412-9.
30. Chen YJ, Lin SC, Kao T, et al. Genome-wide profiling of oral squamous cell carcinoma. J Pathol 2004;204:326-32.
31. Shinozaki H, Ozawa S, Ando N, et al. Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information. Clin Cancer Res 1996;2:1155-61.
32. Sarbia M, Stahl M, Fink U, et al. Prognostic significance of cyclin D1 in esophageal squamous cell carcinoma patients treated with surgery alone or combined therapy modalities. Int J Cancer 1999;84:86-91.
33. Nagasawa S, Onda M, Sasajima K, et al. Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinoma. J Surg Oncol 2001;78:208-14.
34. Shiozaki H, Doki Y, Yamana H, Isono K. A multiinstitutional study of immunohistochemical investigation for the roles of cyclin D1 and E-cadherin in superficial squamous cell carcinoma of the esophagus. J Surg Oncol 2002;79:166-73.
35. Bizari L, Borim AA, Leite KR, et al. Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. Cancer Genet Cytogenet 2006;165:41-50.
36. Sheyn I, Noffsinger AE, Heffelfinger S, Davis B, Miller MA, Fenoglio-Preiser CM. Amplification and expression of the cyclin D1 gene in anal and esophageal squamous cell carcinomas. Hum Pathol 1997;28:270-6.
37. Lua BL, Low BC. Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Lett 2005;579:577-85.
38. Bowden ET, Barth M, Thomas D, Glazer RI, Mueller SC. An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene 1999;18:4440-9.
39. Chuma M, Sakamoto M, Yasuda J, et al. Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol 2004;41:629-36.
40. Reginato MJ, Mills KR, Paulus JK, et al. Integrals and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003;5:733-40.
41. Timpson P, Lynch DK, Schramek D, Walker F, Daly RJ. Cortactin overexpression inhibits ligand-induced downregulation of the epidermal growth factor receptor. Cancer Res 2005;65:3273-80.
42. Okamura H, Resh MD. p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells. J Biol Chem 1995;270:26613-8.
43. Sasaki AT, Chun C, Takeda K, Firtel RA. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement J Cell Biol 2004;167:505-18.
44. Zhao DZ, Wang GF, Speal B, Ma H. The excess microsporocytesl gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther. Genes Dev 2002;16:2021-31.