Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY

Journal of the National Cancer Institute

Volumn 97, Issue 17, 2005, Pages 1302-1306

  Raouf, Afshin ^a   Brown, Lindsay ^b,c   Vrcelj, Nikoleta ^b,c   To, Karen ^a   Kwok, Winnie ^a   Huntsman, David H ^b,c   Eaves, Connie J E ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; MITOMYCIN C; PROTEIN EMSY; TELOMERASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; COMPLEMENTARY DNA; CROSS LINKING REAGENT; EMSY PROTEIN, HUMAN; MITOMYCIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN; TUMOR PROTEIN;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CELL IMMORTALIZATION; CHI SQUARE TEST; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; FREQUENCY ANALYSIS; GENE CONSTRUCT; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; KARYOTYPE; METAPHASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANEUPLOIDY; BREAST; BREAST TUMOR; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INTERPHASE; LENTIVIRINAE; METABOLISM; UPREGULATION;

ANEUPLOIDY; ANTIBIOTICS, ANTINEOPLASTIC; BRCA2 PROTEIN; BREAST; BREAST NEOPLASMS; CROSS-LINKING REAGENTS; DNA, COMPLEMENTARY; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC INSTABILITY; HUMANS; INTERPHASE; LENTIVIRUS; METAPHASE; MITOMYCIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 24744443338     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dji254     Document Type: Article

References (14)

1. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, et al. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003;115:523-35.
2. Nordling M, Karlsson P, Wahlstrom J, Engwall Y, Wallgren A, Martinsson T. A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family. Cancer Res 1998;58:1372-5.
3. Rodriguez C, Hughes-Davies L, Valles H, Orsetti B, Cuny M, Ursule L, et al. Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome. Clin Cancer Res 2004;10: 5785-91.
4. Livingston DM. EMSY, a BRCA-2 partner in crime. Nat Med 2004;10:127-8.
5. Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004;4:814-9.
6. King MC. A novel BRCA2-binding protein and breast and ovarian tumorigenesis. N Engl J Med 2004;350:1252-3.
7. Yu VP, Koehler M, Steinlein C, Schmid M, Hanakahi LA, van Gool AJ, et al. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev 2000;14:1400-6.
8. Tutt A, Bertwistle D, Valentine J, Gabriel A, Swift S, Ross G, et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J 2001;20:4704-16.
9. Donoho G, Brenneman MA, Cui TX, Donoviel D, Vogel H, Goodwin EH, et al. Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer 2003;36:31731.
10. Meng ZH, Ben Y, Li Z, Chew K, Ljung BM, Lagios MD, et al. Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization. Genes Chromosomes Cancer 2004;41:214-22.
11. Imren S, Fabry ME, Westerman KA, Pawliuk P, Tang P, Rosten PM, et al. High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest 2004;114:953-62.
12. Yaswen P, Stampfer MR. Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells. Int J Biochem Cell Biol 2002;34:138294.
13. Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C, et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997;386:804-10.
14. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005;434:913-7.