메뉴 건너뛰기




Volumn 16, Issue 4, 2006, Pages 285-296

Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma

Author keywords

Gene expression; Invasion; p21 activated kinase 1; Uveal melanoma

Indexed keywords

MATRIGEL; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 7; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 33746260317     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cmr.0000222589.30117.f2     Document Type: Article
Times cited : (25)

References (79)
  • 1
    • 0026595855 scopus 로고
    • A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988
    • Diener-West M, Hawkins BS, Markowitz JA, Schachat AP. A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988. Arch Ophthalmol 1992; 110:245-250.
    • (1992) Arch Ophthalmol , vol.110 , pp. 245-250
    • Diener-West, M.1    Hawkins, B.S.2    Markowitz, J.A.3    Schachat, A.P.4
  • 2
    • 0027468605 scopus 로고
    • Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma
    • Gamel JW, McLean IW, McCurdy JB. Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma. Cancer 1993; 71:2299-2305.
    • (1993) Cancer , vol.71 , pp. 2299-2305
    • Gamel, J.W.1    McLean, I.W.2    McCurdy, J.B.3
  • 3
    • 0026716204 scopus 로고
    • Biology of tumour metastasis
    • Hart IR, Saini A. Biology of tumour metastasis. Lancet 1992; 339: 1453-1457.
    • (1992) Lancet , vol.339 , pp. 1453-1457
    • Hart, I.R.1    Saini, A.2
  • 4
    • 0035417897 scopus 로고    scopus 로고
    • Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma
    • Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, Bilban M, et al. Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res 2001; 61:6322-6327.
    • (2001) Cancer Res , vol.61 , pp. 6322-6327
    • Seftor, R.E.1    Seftor, E.A.2    Koshikawa, N.3    Meltzer, P.S.4    Gardner, L.M.5    Bilban, M.6
  • 5
    • 0034989584 scopus 로고    scopus 로고
    • A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins
    • Elshaw SR, Sisley K, Cross N, Murray AK, MacNeil SM, Wagner M, et al. A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins. Br J Ophthalmol 2001; 85:732-738.
    • (2001) Br J Ophthalmol , vol.85 , pp. 732-738
    • Elshaw, S.R.1    Sisley, K.2    Cross, N.3    Murray, A.K.4    MacNeil, S.M.5    Wagner, M.6
  • 6
    • 16844364663 scopus 로고    scopus 로고
    • Invasive and noninvasive uveal melanomas have different adhesive properties
    • Woodward JK, Rennie IG, Elshaw SR, Burn JL, Sisley K. Invasive and noninvasive uveal melanomas have different adhesive properties. Eye 2005; 19:342-348.
    • (2005) Eye , vol.19 , pp. 342-348
    • Woodward, J.K.1    Rennie, I.G.2    Elshaw, S.R.3    Burn, J.L.4    Sisley, K.5
  • 7
    • 0034601455 scopus 로고    scopus 로고
    • Molecular classification of cutaneous malignant melanoma by gene expression profiling
    • Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M, et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 2000; 406:536-540.
    • (2000) Nature , vol.406 , pp. 536-540
    • Bittner, M.1    Meltzer, P.2    Chen, Y.3    Jiang, Y.4    Seftor, E.5    Hendrix, M.6
  • 9
    • 0038701967 scopus 로고    scopus 로고
    • Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities
    • Tschentscher F, Husing J, Holter T, Kruse E, Dresen IG, Jockel KH, et al. Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res 2003; 63:2578-2584.
    • (2003) Cancer Res , vol.63 , pp. 2578-2584
    • Tschentscher, F.1    Husing, J.2    Holter, T.3    Kruse, E.4    Dresen, I.G.5    Jockel, K.H.6
  • 10
    • 18844368501 scopus 로고    scopus 로고
    • DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma
    • Ehlers JP, Worley L, Onken MD, Harbour JW. DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma. Clin Cancer Res 2005; 11:3609-3613.
    • (2005) Clin Cancer Res , vol.11 , pp. 3609-3613
    • Ehlers, J.P.1    Worley, L.2    Onken, M.D.3    Harbour, J.W.4
  • 11
    • 16344362449 scopus 로고    scopus 로고
    • NBS1 expression as a prognostic marker in uveal melanoma
    • Ehlers JP, Harbour JW. NBS1 expression as a prognostic marker in uveal melanoma. Clin Cancer Res 2005; 11:1849-1853.
    • (2005) Clin Cancer Res , vol.11 , pp. 1849-1853
    • Ehlers, J.P.1    Harbour, J.W.2
  • 12
    • 5644251671 scopus 로고    scopus 로고
    • Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death
    • Onken MD, Worley LA, Ehlers JP, Harbour JW. Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res 2004; 64:7205-7209.
    • (2004) Cancer Res , vol.64 , pp. 7205-7209
    • Onken, M.D.1    Worley, L.A.2    Ehlers, J.P.3    Harbour, J.W.4
  • 13
    • 26844520916 scopus 로고    scopus 로고
    • Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas
    • Onken MD, Lin AY, Worley LA, Folberg R, Harbour JW. Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas. Am J Ophthalmol 2005; 140:748-749.
    • (2005) Am J Ophthalmol , vol.140 , pp. 748-749
    • Onken, M.D.1    Lin, A.Y.2    Worley, L.A.3    Folberg, R.4    Harbour, J.W.5
  • 16
    • 0032472918 scopus 로고    scopus 로고
    • Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
    • Daniels RH, Hall PS, Bokoch GM. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J 1998; 17:754-764.
    • (1998) EMBO J , vol.17 , pp. 754-764
    • Daniels, R.H.1    Hall, P.S.2    Bokoch, G.M.3
  • 17
    • 0031036626 scopus 로고    scopus 로고
    • Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
    • Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, Leung T, Lim L. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 1997; 17:1129-1143.
    • (1997) Mol Cell Biol , vol.17 , pp. 1129-1143
    • Manser, E.1    Huang, H.Y.2    Loo, T.H.3    Chen, X.Q.4    Dong, J.M.5    Leung, T.6    Lim, L.7
  • 18
    • 0033577902 scopus 로고    scopus 로고
    • p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
    • Sells MA, Boyd JT, Chernoff J. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol 1999; 145:837-849.
    • (1999) J Cell Biol , vol.145 , pp. 837-849
    • Sells, M.A.1    Boyd, J.T.2    Chernoff, J.3
  • 19
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, et al. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 2000; 275:36238-36244.
    • (2000) J Biol Chem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5    Sahin, A.6
  • 20
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 1998; 273:28238-28246.
    • (1998) J Biol Chem , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 21
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 2000; 275: 12041-12050.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 23
    • 0027197111 scopus 로고
    • Studies of human uveal melanocytes in vitro: Isolation, purification and cultivation of human uveal melanocytes
    • Hu DN, McCormick SA, Ritch R, Pelton-Henrion K. Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes. Invest Ophthalmol Vis Sci 1993; 34:2210-2219.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 2210-2219
    • Hu, D.N.1    McCormick, S.A.2    Ritch, R.3    Pelton-Henrion, K.4
  • 24
    • 0023499529 scopus 로고
    • A simple quantitative assay for studying the invasive potential of high and low human metastatic variants
    • Hendrix MJ, Seftor EA, Seftor RE, Fidler IJ. A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett 1987; 38:137-147.
    • (1987) Cancer Lett , vol.38 , pp. 137-147
    • Hendrix, M.J.1    Seftor, E.A.2    Seftor, R.E.3    Fidler, I.J.4
  • 25
    • 0029875130 scopus 로고    scopus 로고
    • Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF)
    • Cha D, O'Brien P, O'Toole EA, Woodley DT, Hudson LG. Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF). J Invest Dermatol 1996; 106:590-597.
    • (1996) J Invest Dermatol , vol.106 , pp. 590-597
    • Cha, D.1    O'Brien, P.2    O'Toole, E.A.3    Woodley, D.T.4    Hudson, L.G.5
  • 26
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998; 280:1614-1617.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 27
    • 0028080094 scopus 로고
    • The role of extracellular matrix in human astrocytoma migration and proliferation studied in a microliter scale assay
    • Berens ME, Rief MD, Loo MA, Giese A. The role of extracellular matrix in human astrocytoma migration and proliferation studied in a microliter scale assay. Clin Exp Metastasis 1994; 12:405-415.
    • (1994) Clin Exp Metastasis , vol.12 , pp. 405-415
    • Berens, M.E.1    Rief, M.D.2    Loo, M.A.3    Giese, A.4
  • 28
    • 0029789573 scopus 로고    scopus 로고
    • Contrasting migratory response of astrocytoma cells to tenascin mediated by different integrins
    • Giese A, Loo MA, Norman SA, Treasurywala S, Berens ME. Contrasting migratory response of astrocytoma cells to tenascin mediated by different integrins. J Cell Sci 1996; 109 (Pt 8):2161-2168.
    • (1996) J Cell Sci , vol.109 , Issue.8 PART , pp. 2161-2168
    • Giese, A.1    Loo, M.A.2    Norman, S.A.3    Treasurywala, S.4    Berens, M.E.5
  • 29
    • 2942533921 scopus 로고    scopus 로고
    • Microarray expression profiling in melanoma reveals a BRAF mutation signature
    • Pavey S, Johansson P, Packer L, Taylor J, Stark M, Pollock PM, et al. Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene 2004; 23:4060-4067.
    • (2004) Oncogene , vol.23 , pp. 4060-4067
    • Pavey, S.1    Johansson, P.2    Packer, L.3    Taylor, J.4    Stark, M.5    Pollock, P.M.6
  • 30
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 31
    • 0024461004 scopus 로고
    • Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells
    • Boyer B, Tucker GC, Valles AM, Franke WW, Thiery JP. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J Cell Biol 1989; 109:1495-1509.
    • (1989) J Cell Biol , vol.109 , pp. 1495-1509
    • Boyer, B.1    Tucker, G.C.2    Valles, A.M.3    Franke, W.W.4    Thiery, J.P.5
  • 33
    • 0027650575 scopus 로고
    • Adhesion molecules in tumor metastasis
    • Zetter BR. Adhesion molecules in tumor metastasis. Semin Cancer Biol 1993; 4:219-229.
    • (1993) Semin Cancer Biol , vol.4 , pp. 219-229
    • Zetter, B.R.1
  • 34
    • 0033376770 scopus 로고    scopus 로고
    • Cell adhesion molecules in the development and progression of malignant melanoma
    • Johnson JP. Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 1999; 18:345-357.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 345-357
    • Johnson, J.P.1
  • 35
    • 0033389362 scopus 로고    scopus 로고
    • Molecular role(s) for integrins in human melanoma invasion
    • Seftor RE, Seftor EA, Hendrix MJ. Molecular role(s) for integrins in human melanoma invasion. Cancer Metastasis Rev 1999; 18:359-375.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 359-375
    • Seftor, R.E.1    Seftor, E.A.2    Hendrix, M.J.3
  • 36
    • 0034955641 scopus 로고    scopus 로고
    • Expression of integrins, degradative enzymes and their inhibitors in uveal melanoma: Differences between in vitro and in vivo expression
    • Baker JK, Elshaw SR, Mathewman GE, Nichols CE, Murray AK, Parsons MA, et al. Expression of integrins, degradative enzymes and their inhibitors in uveal melanoma: differences between in vitro and in vivo expression. Melanoma Res 2001; 11:265-273.
    • (2001) Melanoma Res , vol.11 , pp. 265-273
    • Baker, J.K.1    Elshaw, S.R.2    Mathewman, G.E.3    Nichols, C.E.4    Murray, A.K.5    Parsons, M.A.6
  • 37
    • 0033894905 scopus 로고    scopus 로고
    • Expression of VLA-2, VLA-3, and alpha(v) integrin receptors in uveal melanoma: Association with microvascular architecture of the tumour and prognostic value
    • Anastassiou G, Schilling H, Djakovic S, Bornfeld N. Expression of VLA-2, VLA-3, and alpha(v) integrin receptors in uveal melanoma: association with microvascular architecture of the tumour and prognostic value. Br J Ophthalmol 2000; 84:899-902.
    • (2000) Br J Ophthalmol , vol.84 , pp. 899-902
    • Anastassiou, G.1    Schilling, H.2    Djakovic, S.3    Bornfeld, N.4
  • 38
    • 0033957130 scopus 로고    scopus 로고
    • Expression of the cell adhesion molecules ICAM-1, VCAM-1 and NCAM in uveal melanoma: A clinicopathological study
    • Anastassiou G, Schilling H, Stang A, Djakovic S, Heiligenhaus A, Bornfeld N. Expression of the cell adhesion molecules ICAM-1, VCAM-1 and NCAM in uveal melanoma: a clinicopathological study. Oncology 2000; 58:83-88.
    • (2000) Oncology , vol.58 , pp. 83-88
    • Anastassiou, G.1    Schilling, H.2    Stang, A.3    Djakovic, S.4    Heiligenhaus, A.5    Bornfeld, N.6
  • 39
    • 16844364663 scopus 로고    scopus 로고
    • Invasive and noninvasive uveal melanomas have different adhesive properties
    • Woodward JK, Rennie IG, Elshaw SR, Burn JL, Sisley K. Invasive and noninvasive uveal melanomas have different adhesive properties. Eye 2005; 19:342-348.
    • (2005) Eye , vol.19 , pp. 342-348
    • Woodward, J.K.1    Rennie, I.G.2    Elshaw, S.R.3    Burn, J.L.4    Sisley, K.5
  • 40
    • 23744432051 scopus 로고    scopus 로고
    • Essential role of CIB1 in regulating PAK1 activation and cell migration
    • Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV. Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol 2005; 170:465-476.
    • (2005) J Cell Biol , vol.170 , pp. 465-476
    • Leisner, T.M.1    Liu, M.2    Jaffer, Z.M.3    Chernoff, J.4    Parise, L.V.5
  • 41
    • 0036678475 scopus 로고    scopus 로고
    • Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization
    • Papakonstanti EA, Stournaras C. Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell 2002; 13:2946-2962.
    • (2002) Mol Biol Cell , vol.13 , pp. 2946-2962
    • Papakonstanti, E.A.1    Stournaras, C.2
  • 42
    • 1242271205 scopus 로고    scopus 로고
    • Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
    • Bagnato A, Rosano L, Spinella F, Di Castro V, Tecce R, Natali PG. Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression. Cancer Res 2004; 64:1436-1443.
    • (2004) Cancer Res , vol.64 , pp. 1436-1443
    • Bagnato, A.1    Rosano, L.2    Spinella, F.3    Di Castro, V.4    Tecce, R.5    Natali, P.G.6
  • 43
    • 0028987936 scopus 로고
    • Integrins and signal transduction pathways: The road taken
    • Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science 1995; 268:233-239.
    • (1995) Science , vol.268 , pp. 233-239
    • Clark, E.A.1    Brugge, J.S.2
  • 44
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
    • Gilmore AP, Romer LH. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol Biol Cell 1996; 7:1209-1224.
    • (1996) Mol Biol Cell , vol.7 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2
  • 45
    • 0029039421 scopus 로고
    • Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
    • Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, Kornberg L, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 1995; 55:2752-2755.
    • (1995) Cancer Res , vol.55 , pp. 2752-2755
    • Owens, L.V.1    Xu, L.2    Craven, R.J.3    Dent, G.A.4    Weiner, T.M.5    Kornberg, L.6
  • 47
  • 48
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
    • Leung T, Manser E, Tan L, Lim L. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem 1995; 270:29051-29054.
    • (1995) J Biol Chem , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 49
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992; 70:389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 51
    • 0032478605 scopus 로고    scopus 로고
    • A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids
    • Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem 1998; 273:8137-8144.
    • (1998) J Biol Chem , vol.273 , pp. 8137-8144
    • Bokoch, G.M.1    Reilly, A.M.2    Daniels, R.H.3    King, C.C.4    Olivera, A.5    Spiegel, S.6    Knaus, U.G.7
  • 52
    • 0032532310 scopus 로고    scopus 로고
    • Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils
    • Lian JP, Huang R, Robinson D, Badwey JA. Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. J Immunol 1998; 161:4375-4381.
    • (1998) J Immunol , vol.161 , pp. 4375-4381
    • Lian, J.P.1    Huang, R.2    Robinson, D.3    Badwey, J.A.4
  • 55
    • 0033525229 scopus 로고    scopus 로고
    • Pix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms
    • Daniels RH, Zenke FT, Bokoch GM. alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J Biol Chem 1999; 274:6047-6050.
    • (1999) J Biol Chem , vol.274 , pp. 6047-6050
    • Daniels, R.H.1    Zenke, F.T.2    Alpha, B.G.M.3
  • 58
    • 0034082699 scopus 로고    scopus 로고
    • Interaction between PAK and nck: A template for Nck targets and role of PAK autophosphorylation
    • Zhao ZS, Manser E, Lim L. Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol 2000; 20:3906-3917.
    • (2000) Mol Cell Biol , vol.20 , pp. 3906-3917
    • Zhao, Z.S.1    Manser, E.2    Lim, L.3
  • 60
    • 0035966018 scopus 로고    scopus 로고
    • Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology
    • Rashid T, Banerjee M, Nikolic M. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J Biol Chem 2001; 276:49043-49052.
    • (2001) J Biol Chem , vol.276 , pp. 49043-49052
    • Rashid, T.1    Banerjee, M.2    Nikolic, M.3
  • 61
    • 0034282225 scopus 로고    scopus 로고
    • Regulation of anchorage-dependent signal transduction by protein kinase a and p21-activated kinase
    • Howe AK, Juliano RL. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol 2000; 2:593-600.
    • (2000) Nat Cell Biol , vol.2 , pp. 593-600
    • Howe, A.K.1    Juliano, R.L.2
  • 62
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 1997; 16:6426-6438.
    • (1997) EMBO J , vol.16 , pp. 6426-6438
    • Frost, J.A.1    Steen, H.2    Shapiro, P.3    Lewis, T.4    Ahn, N.5    Shaw, P.E.6    Cobb, M.H.7
  • 63
    • 0032511882 scopus 로고    scopus 로고
    • The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
    • King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 1998; 396:180-183.
    • (1998) Nature , vol.396 , pp. 180-183
    • King, A.J.1    Sun, H.2    Diaz, B.3    Barnard, D.4    Miao, W.5    Bagrodia, S.6    Marshall, M.S.7
  • 65
    • 0036333485 scopus 로고    scopus 로고
    • Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
    • Eblen ST, Slack JK, Weber MJ, Catling AD. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol 2002; 22:6023-6033.
    • (2002) Mol Cell Biol , vol.22 , pp. 6023-6033
    • Eblen, S.T.1    Slack, J.K.2    Weber, M.J.3    Catling, A.D.4
  • 67
    • 0034698675 scopus 로고    scopus 로고
    • Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42
    • Adams JC, Schwartz MA. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol 2000; 150:807-822.
    • (2000) J Cell Biol , vol.150 , pp. 807-822
    • Adams, J.C.1    Schwartz, M.A.2
  • 69
    • 0031050582 scopus 로고    scopus 로고
    • Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: Influences of the ability of cells to migrate through the filter membrane
    • Sieuwerts AM, Klijn JG, Foekens JA. Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane. Clin Exp Metastasis 1997; 15:53-62.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 53-62
    • Sieuwerts, A.M.1    Klijn, J.G.2    Foekens, J.A.3
  • 72
    • 0026542056 scopus 로고
    • Integrin expression in human melanoma cells with differing invasive and metastatic properties
    • Gehlsen KR, Davis GE, Sriramarao P. Integrin expression in human melanoma cells with differing invasive and metastatic properties. Clin Exp Metastasis 1992; 10:111-120.
    • (1992) Clin Exp Metastasis , vol.10 , pp. 111-120
    • Gehlsen, K.R.1    Davis, G.E.2    Sriramarao, P.3
  • 73
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, et al. Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 2003; 163:985-992.
    • (2003) Am J Pathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5    Ruffalo, T.6
  • 75
    • 0345300537 scopus 로고    scopus 로고
    • Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa)
    • Barnes CJ, Bagheri-Yarmand R, Mandal M, Yang Z, Clayman GL, Hong WK, Kumar R. Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). Mol Cancer Ther 2003; 2:345-351.
    • (2003) Mol Cancer Ther , vol.2 , pp. 345-351
    • Barnes, C.J.1    Bagheri-Yarmand, R.2    Mandal, M.3    Yang, Z.4    Clayman, G.L.5    Hong, W.K.6    Kumar, R.7
  • 76
    • 10744219536 scopus 로고    scopus 로고
    • The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells
    • Yang Z, Bagheri-Yarmand R, Wang RA, Adam L, Papadimitrakopoulou VV, Clayman GL, et al. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Clin Cancer Res 2004; 10:658-667.
    • (2004) Clin Cancer Res , vol.10 , pp. 658-667
    • Yang, Z.1    Bagheri-Yarmand, R.2    Wang, R.A.3    Adam, L.4    Papadimitrakopoulou, V.V.5    Clayman, G.L.6
  • 77
    • 0035716159 scopus 로고    scopus 로고
    • Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation
    • He H, Hirokawa Y, Manser E, Lim L, Levitzki A, Maruta H. Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer J 2001; 7:191-202.
    • (2001) Cancer J , vol.7 , pp. 191-202
    • He, H.1    Hirokawa, Y.2    Manser, E.3    Lim, L.4    Levitzki, A.5    Maruta, H.6
  • 78
    • 3142520112 scopus 로고    scopus 로고
    • The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
    • He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, et al. The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol Ther 2004; 3:96-101.
    • (2004) Cancer Biol Ther , vol.3 , pp. 96-101
    • He, H.1    Hirokawa, Y.2    Gazit, A.3    Yamashita, Y.4    Mano, H.5    Kawakami, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.