Focal amplification and oncogene dependency of GAB2 in breast cancer

Oncogene

Volumn 29, Issue 5, 2010, Pages 774-779

  Bocanegra, M ^a   Bergamaschi, A ^a,b   Kim, Y H ^a   Miller, M A ^c   Rajput, A B ^c   Kao, J ^a   Langerod A ^b   Han, W ^d   Noh, D Y ^d   Jeffrey, S S ^e   Huntsman, D G ^e   Borresen Dale A L ^b   Pollack, J R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Seoul National University   (South Korea)

^e STANFORD UNIVERSITY   (United States)

Author keywords

Array based comparative genomic hybridization; Breast cancer; DNA amplification; GAB2; Genomic profiling; Oncogene dependency

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GRB2 ASSOCIATED BINDING PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST TUMOR; CANCER CELL CULTURE; CCND1 GENE; CELL CYCLE PROGRESSION; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME 11Q; GAB2 GENE; GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTO ONCOGENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENES; SIGNAL TRANSDUCTION;

MURINAE;

EID: 76349105055     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.364     Document Type: Article

References (19)

1. Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, et al. (2006). A role for the scaffolding adapter GAB2 in breast cancer. Nat Med 12: 114-121.
2. Bergamaschi A, Kim YH, Kwei KA, Choi Y-L, Bocanegra M, Langer0d A, et al. (2008). CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer. Mol Oncol 2: 327-339.
3. Brummer T, Schramek D, Hayes VM, Bennett HL, Caldon CE, Musgrove EA, et al. (2006). Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem 281: 626-637.
4. Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, et al. (2006). Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10: 529-541.
5. Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, et al. (2002). The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. Oncogene 21: 5175-5181.
6. Gu H, Neel BG (2003). The 'Gab' in signal transduction. Trends Cell Biol 13: 122-130.
7. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, et al. (2003). EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115: 523-535.
8. Ischenko I, Petrenko O, Gu H, Hayman MJ. (2003). Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase. Oncogene 22: 6311-6318.
9. Jemal A, Ward E, Thun MJ. (2007). Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Res 9: R28.
10. Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, et al. (2009). Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS ONE 4: e6146.
11. Karlseder J, Zeillinger R, Schneeberger C, Czerwenka K, Speiser P, Kubista E, et al. (1994). Patterns of DNA amplification at band q13 of chromosome 11 in human breast cancer. Genes Chromosomes Cancer 9: 42-48.
12. Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, et al. (2007). Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene 26: 4951-4960.
13. Ormandy CJ, Musgrove EA, Hui R, Daly RJ, Sutherland RL. (2003). Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat 78: 323-335.
14. Pegram MD, Konecny G, Slamon DJ. (2000). The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat Res 103: 57-75.
15. Pollack JR, Sorlie T, Perou CM, Rees CA, Jeffrey SS, Lonning PE, et al. (2002). Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci USA 99: 12963-12968.
16. Sarmay G, Angyal A, Kertesz A, Maus M, Medgyesi D. (2006). The multiple function of Grb2 associated binder (Gab) adaptor/ scaffolding protein in immune cell signaling. Immunol Lett 104: 76-82.
17. Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, et al. (2002). Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 1: 479-492.
18. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. (2001). Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98: 10869-10874.
19. Tibshirani R, Wang P. (2008). Spatial smoothing and hot spot detection for CGH data using the fused lasso. Biostatistics 9: 18-29.